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Twenty Years of Research and Development on Soil Pollution and Remediation in China
This book reviews the progresses and achievements made in the past 20 years of research on soil pollution and remediation in China, and presents 50 review and research articles from all over China, including Hong Kong and Taiwan. The authors include scientists, engineers, entrepreneurs and managers from 26 universities, 18 institutes, 4 leading enterprises and 2 government environmental protection departments. The contents cover fundamental research on soil pollution and remediation, technical development, project demonstration, policy and governance. The polluted soil/site types include farmland, industrial sites, mining areas and oilfields, with heavy metals (cadmium, arsenic, copper, chro...
Current Status of Natural Products Targeting Alzheimer’s Disease
Despite more than fifty years of intensive research on Alzheimer’s disease (AD) drug discovery, up till now only four medicines are approved by FDA for its treatment; among which three are acetylcholinesterase (AChE) inhibitors (donepezil, galantamine, and rivastigmine) and one is N-Methyl-D-aspartate (NMDA) antagonist memantine. These medications were launched during the initial research for AD but were not able to provide satisfactory results because of their limited efficacy and numerous side effects. The high-profile failure of late-stage clinical trials by prominent pharma firms for biomolecules that showed promising results in experimental models has added to the dissatisfaction of d...
From Oxidative Stress to Cognitive Decline - Towards Novel Therapeutic Approaches
Oxidative stress plays multiple roles in the pathobiology of several neurodegenerative disorders and Alzheimer’s disease in particular. Increased oxidative stress in the brain is suggested to be associated with aging, greater amounts of easily oxidizable unsaturated fatty acids, higher utilization of oxygen by the brain, mitochondrial-derived free radicals, calcium homeostasis, and glutamate-induced excitotoxicity. Moreover, environmental chemicals/toxins, heavy metals, and an imbalanced diet might increase oxidative stress potentially leading to a decrease in cognitive functions. Cellular health is also dependent on the levels of nicotinamide adenine dinucleotide (NAD+). It has been well ...
Pattern Recognition
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