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Pharmaceutical Engineering Change Control
Written especially for the pharmaceutical industry professional, this book addresses each part of the life-cycle of engineering change control. It covers issues in the EU and US and describes the operational requirements and responsibilities that ensure change controls are effectively applied and recorded. Providing guidance on how to demonstrate that a change control system is working, the book includes chapters on computer validation, customization of the change process to each project's needs, and case histories and anecdotes illustrate key points and provide a basis for change control training. It gives readers a toolbox for ensuring that adequate controls are implemented.
Immunology of Human Infection
When we were first approached by the senior editors of this series to edit a book on interactions between the host and infectious agents, we accepted this offer as an exciting challenge. The only condition, readily agreed upon, was that such a book should focus on the immunology of infections in humans. Our reasons, if not biases, were severalfold. We sensed that the fields of microbiology and im munology, which had diverged as each was focusing on its individual search, were coming together. In agreement with the opinions expressed by Dr. Richard Krause in the Introduction, we strongly believed that the development of the immune system evolved in response to infectious agents and that the e...
Late Phase Allergic Reactions
This important publication presents new information regarding "Late Phase Allergic (or Inflammatory) Reactions" (LPR). It includes present knowledge on the pathogenesis of LPR in human skin, nose, bronchi, and other organ systems. The book discusses the roles of antibodies, mediators, and cells as well as animal models of LPR. It describes the importance of LPR in the pathogenesis of chronic disease and the possibilities of their pharmacological modulation. The authors discuss clinical conclusions to be drawn from the observation of LPR, such as continuous treatment and immunotherapy. This volume is a useful reference for scientists and clinicians wishing to understand more about the problems of their allergic patients.
Asthma
Now available in its Third Edition, Asthma: Basic Mechanisms and Clinical Management has become the reference text in asthma. This highly successful text sheds new light on the basic physiological and molecular mechanisms of asthma, how current treatments work, and how best to apply the latest knowledge to control this important disease. The Third Edition has undergone radical revision and includes several new chapters. It retains the virtues of the previous volumes by bringing together all of the recent research findings by internationally recognized experts on the causative mechanisms of asthma, including in-depth clinical aspects and therapy. The book presents an integrated approach toward the treatment of this disease with new concepts, changes in asthma management, and the development of new therapeutic agents. Asthma provides extensive references for researchers and clinicians who need to keep abreast of recent developments in this rapidly expanding field. - Comprehensive coverage of both basic science and clinical aspects of asthma - Extensively referenced throughout
If Only
It is often tempting to believe in the grand sweep of history; to conclude that the triumphs of great teams were simply inevitable. The truth, however, is that history can turn on what appear, at frst glance, to be infnitesimally small events. Behind all those triumphs lie the countless disappointments of teams that were denied glory by a cruel bounce, the width of a crossbar or a dubious refereeing decision. Challenging the perception that the outcome of great clashes couldn't have been any dfferent, If Only reflects on what soccer history could have been, what it might have been and, in some cases, what it probably should have been. It imagines a world in which Scotland win the frst-ever World Cup, Derby County are champions of Europe and 1966 isn't the only year that England win anything.
