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Evolution of Genetic Mechanisms of Antibiotic Resistance
Since the first introduction of antibiotics into clinical practice, microbial drug resistance has emerged as a major obstacle in the treatment of infections. Recently, the combination of emergence of a complex variety of multidrug resistant strains and the dearth of newly discovered molecules to effectively target and eliminate these strains, has made antibiotic resistance one of the major public health problems of this century. Although different strategies can be adopted to contain the emergence and spread of antibiotic resistance, including (i) antimicrobial stewardship, (ii) infection control, and (iii) tighter control over the use of antibiotics in agriculture and breeding, a better und...
Antimicrobials
Reports on the emergence and prevalence of resistant bacterial infections in hospitals and communities raise concerns that we may soon no longer be able to rely on antibiotics as a way to control infectious diseases. Effective medical care would require the constant introduction of novel antibiotics to keep up in the “arms race” with resistant pathogens. This book closely examines the latest developments in the field of antibacterial research and development. It starts with an overview of the growing prevalence of resistant Gram-positive and Gram-negative pathogens, including their various resistance mechanisms, prevalence, risk factors and therapeutic options. The focus then shifts to a comprehensive description of all major chemical classes with antibacterial properties, their chemistry, mode of action, and the generation of analogs; information that provides the basis for the design of improved molecules to defeat microbial infections and combat the emerging resistances. In closing, recently developed compounds already in clinical use, those in preclinical or first clinical studies, and a number of promising targets to be exploited in the discovery stage are discussed.
An Introduction to Undergraduate Research in Computational and Mathematical Biology
Speaking directly to the growing importance of research experience in undergraduate mathematics programs, this volume offers suggestions for undergraduate-appropriate research projects in mathematical and computational biology for students and their faculty mentors. The aim of each chapter is twofold: for faculty, to alleviate the challenges of identifying accessible topics and advising students through the research process; for students, to provide sufficient background, additional references, and context to excite students in these areas and to enable them to successfully undertake these problems in their research. Some of the topics discussed include: • Oscillatory behaviors present in ...
ZoneModa Journal 03
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Who's who in Italy
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Kiwifruit
Kiwifruit is one of the few fruit crops that has been successfully introduced to the marketplace and for which commercial production in several countries has expanded rapidly over the last 50 years. Kiwifruit science and production has advanced significantly during this time, with multiple new green-, yellow- and red-fleshed cultivars being commercialized while moving into the era of genomics, sustainability, digital technology and automation. This book reviews the scientific and technical information published on kiwifruit, their biology and management. It provides a comprehensive reference on kiwifruit, including their history, genetic material, culture, physiology, pest and disease control, and fruit consumption. Particular attention is given to recent threats and opportunities, including environmental issues, the disease Pseudomonas syringae pv. actinidiae, new genetics, new growing areas and technology advances. Contributions from a wide range of international specialists ensure coverage of key aspects of kiwifruit and their culture in different environments.
Architecture and the Novel under the Italian Fascist Regime
Architecture and the Novel under the Italian Fascist Regime discusses the relationship between the novel and architecture during the Fascist period in Italy (1922-1943). By looking at two profoundly diverse aesthetic phenomena within the context of the creation of a Fascist State art, Billiani and Pennacchietti argue that an effort of construction, or reconstruction, was the main driving force behind both projects: the advocated “revolution” of the novel form (realism) and that of architecture (rationalism). The book is divided into seven chapters, which in turn analyze the interconnections between the novel and architecture in theory and in practice. The first six chapters cover debates on State art, on the novel and on architecture, as well as their historical development and their unfolding in key journals of the period. The last chapter offers a detailed analysis of some important novels and buildings, which have in practice realized some of the key principles articulated in the theoretical disputes.
