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Computational Methods in Systems Biology
This book constitutes the proceedings of the 12th International Conference on Computational Methods in Systems Biology, CMSB 2014, held in Manchester, UK, in November 2014. The 16 regular papers presented together with 6 poster papers were carefully reviewed and selected from 31 regular and 18 poster submissions. The papers are organized in topical sections on formalisms for modeling biological processes, model inference from experimental data, frameworks for model verification, validation, and analysis of biological systems, models and their biological applications, computational approaches for synthetic biology, and flash posters.
Science
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Aging and Health - A Systems Biology Perspective
Aging is a major risk factor for chronic diseases, which in turn can provide information about the aging of a biological system. This publication serves as an introduction to systems biology and its application to biological aging. Key pathways and processes that impinge on aging are reviewed, and how they contribute to health and disease during aging is discussed. The evolution of this situation is analyzed, and the consequences for the study of genetic effects on aging are presented. Epigenetic programming of aging, as a continuation of development, creates an interface between the genome and the environment. New research into the gut microbiome describes how this interface may operate in ...
Glucokinase and Glycemic Diseases
The glucose-phosphorylating enzyme glucokinase (also known as hexokinase IV) plays a preeminent role as a glucose sensor and regulatory metabolic enzyme. The implications of this central position of glucokinase for the understanding and treatment of diabetes mellitus are far reaching. This book addresses the molecular and human genetic, as well as the physiological-chemical and pharmacological aspects of the role glucokinase plays in glucose homeostasis and diseases of glucose metabolism, and how the enzyme serves as the drug target for the treatment of diabetes mellitus. The collection of assays by a team of internationally renowned authors includes basic science chapters dealing with the e...
DUZ Magazin
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Forschung & Lehre
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Uma noiva alemã por correspondência
Só dois tipos de mulheres aceitam ser noivas por correspondência: as tolas e as desesperadas. Agnes se enquadra em ambos. Depois da morte do pai, sozinha e sem herança, ela responde a um anúncio de noivado por correspondência de um próspero emigrante alemão que vive no Novo Mundo. O que ela não imagina é que o anúncio não foi escrito pelo pretendente. Mas essa é apenas a primeira notícia surpreendente que Agnes vai receber.
