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Multiple Drug Resistance in Cancer 2
Resistance to chemotherapy, and especially multi-drug resistance, represents a significant barrier to the successful treatment of cancer. This multi-author volume brings together a wide range of up-to-date reviews on different aspects of our knowledge of drug-resistance mechanisms, written by experts in the different areas. Particular attention is paid to recently discovered mechanisms relating to oncogene expression and in particular to proteins involved in regulation and execution of apoptosis. Other important topics covered include DNA repair, topoisomerases, cell cycle control, oxygenation and vascularisation of tumours, LRP, intermediate filament proteins and low-level resistance. Recent developments in understanding the role of efflux pumps (P-170, MRP) in multi-drug resistance are also reviewed. This book will be useful to clinicians and scientists working in the areas of chemotherapy, drug resistance, DNA repair and apoptosis research.
Personalized Nutrition in Chronic Kidney Disease
Nutritional status is a crucial prognostic factor in chronic kidney disease (CKD) patients. The nutritional approach depends on the stage of renal disease, patients’ comorbidities, proteins catabolism, and the presence of malnutrition. The gradual and progressive worsening of kidney function, characterized by a reduced glomerular filtration rate, carries many challenges for both young and elderly patients. Dietetic-Nutritional therapy (DTN) has an important role in the prevention and in the progression of Chronic Kidney Disease. An appropriate nutritional approach contributes to the prevention and control of signs, symptoms, and metabolic complications of CKD such as hyperkalemia, hyperpho...
Manual of Cable Osteosyntheses
In bone surgery it is essential to compress fractures interfragmentarily in order to make them resistant to the tensile force of muscles and the force resulting from acceleration and deceleration. This can be best achieved by the use of cable tension bands as a traction mechanism. The cable tension band is - in terms of stability of fractures - far superior to the conventional rigid cerclage wire which has been widely used in osteosynthesis for over 100 years. The author explains the biomechanics of the tension band in detail. Theoretical findings are confirmed by clinical test results. All osteosynthetic techniques which can be carried out with cables are described giving details of operation instructions. Errors and risks are always pointed out. A reference book and operative manual at a time.
Perspectivas da alfabetização
Este livro foi construído coletiva, aberta e questionadoramente, voltando-se para a interlocução com um leitor ativo e construtor de sentidos. Assim, pressupõe múltiplas leituras possíveis, tanto para quem ensina como para quem aprende, abrindo possibilidades para a transformação da prática da alfabetização em seus diferentes níveis. Dessa forma, por meio da plasticidade do olhar atento dos autores sobre os diversos aspectos que mapeiam o tema discutido, se reafirma o compromisso de todos com uma escola inclusiva, convidando o leitor a entrar em cena para incentivá-lo à apropriação desse saber-fazer, rumo à autonomia e ao exercício de uma leitura crítico-reflexiva. É esse movimento que, por tornar-se fonte de aprendizagem e de regulação da prática docente, pode também se tornar alavanca essencial para um processo de autoformação, de renovação didática e de desenvolvimento de novas competências.
Science Abstracts
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Clinical Nephrology
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The Labyrinth of Star Formation
This volume contains the proceedings from the conference "The Labyrinth of Star Formation" that was held in Crete, Greece, in June 2012, to honour the contributions to the study of star formation made by Professor Anthony Whitworth of Cardiff University. The book covers many aspects of theoretical and observational star formation: low-mass star formation; young circumstellar discs; computational methods; triggered star formation; the stellar initial mass function; high-mass star formation and stellar clusters. Each section starts with a review paper, followed by papers discussing recent theoretical and observational work. This volume summarises our current understanding of star formation and is useful for both graduate students and researchers alike.
Science Citation Index
Vols. for 1964- have guides and journal lists.
