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Translational Research in Cancer
Translational research in oncology benefits from an abundance of knowledge resulting from genome-scale studies concerning the molecular pathways involved in tumorigenesis. Translational oncology represents a bridge between basic research and clinical practice in cancer medicine. The vast majority of cancer cases are due to environmental risk factors. Many of these environmental factors are controllable lifestyle choices. Experimental cancer treatments are studied in clinical trials to compare the proposed treatment to the best existing treatment through translational research. The key features of the book include: 1) New screening for the development of radioprotectors: radioprotection and anti-cancer effect of β-Glucan (Enterococcus faecalis) 2) Translational perspective on hepatocellular carcinoma 3) Brachytherapy for endometrial cancer 4) Discovery of small molecule inhibitors for histone methyltransferases in cancer
Update on Bladder Cancer
Bladder cancer is the most common malignancy of the urinary tract and one of the most prevalent cancers worldwide. The bladder microbiota is strongly associated with different statuses of bladder cancer. The increased abundance of microbes such as Schistosoma, Pseudomonas, Streptococcus, Mycobacterium, Bacteroidetes, and Klebsiella is associated with the development of bladder cancer during tumorigenesis. Improved understanding of age-related alterations to the immune system and gut and urinary microbiomes could provide possible insights into bladder cancer development and progression in the elderly. Mitochondrial DNA (mtDNA) content has been shown to be associated with cancer susceptibility. Patients diagnosed with bladder cancer have significantly decreased mtDNA. Cancer prevention strategies are theoretically appealing although often difficult to implement, owing to the multifactorial pathogenesis of most cancers. This book focuses on the diagnosis and prevention of bladder cancer.
Prevention, Detection and Management of Oral Cancer
Up to 70% of oral cancers are preceded by premalignant oral lesions, such as persistent red or white patches in the mouth. Survival rates for oral cancer can be improved through early detection. It is therefore essential that oral health professionals such as dentists, dental hygienists, dental therapists, and oral health therapists understand the importance of conducting a thorough oral screening examination for malignant and potentially malignant lesions as part of their routine clinical assessments, even in younger populations considered at lower risk for oral cancer. Key features of the book include: laser treatment techniques ,human genome sequencing, early detection and multidisciplinary approach ,management strategies and mechanisms of proliferation and energy metabolism in oral cancer.
Clinical Diagnosis and Management of Squamous Cell Carcinoma
Squamous cell carcinoma remains a significant cause of morbidity and mortality. It is a heterogeneous disease with complex molecular abnormalities. Head and neck squamous cell carcinomas (SCC) represent the most frequent human solid tumors and are a major cause of cancer mortality. Highly heterogeneous tumors arise from closely interconnected epithelial cell populations whose intrinsic self-renewal potential is inversely related to the stratified differentiation program. Cancer prevention strategies are theoretically appealing although often difficult to implement, owing to the multifactorial pathogenesis of most cancers. This book focuses on significant variations of squamous cell carcinoma, including squamous cell carcinoma of the vagina, bladder, head and neck.
Evolving Trends in Kidney Cancer
Kidney cancer imposes a significant cancer burden and its incidence continues to rise globally. Mortality in advanced kidney cancer remains high despite oncological, surgical and multimodal optimisation. Genetic associations, heterogeneity and limitations in early diagnosis through lack of optimal biomarkers add to the challenges. Over the last two decades there has been an exponential increase in diagnostic and therapeutic advances in the management of kidney cancer. The coupling of scientific advances in engineering and technology with oncological therapeutics has recently ushered a renewed optimism. The role of minimally invasive approaches through focal therapy and surgical extirpation u...
Lung Cancer
Lung cancer continues to be the leading cause of cancer mortality worldwide among both men and women. Recent advances in prevention, screening and management in the past decade have led to significant improvements in survival and quality of life. Local treatments like minimally invasive surgery, radiotherapy, and image-guided ablation have contributed to improving the effectiveness and tolerability of potentially curative treatments in early-stage, locally advanced, and oligometastatic/oligoprogressive disease. Chemotherapy, targeted therapy, immunotherapy, and palliative local therapy options have expanded rapidly, with new regimens showing improved outcomes even for those with widely metastatic disease. This book comprehensively reviews the evidence that has driven personalized medicine, based on a variety of multidisciplinary perspectives by international lung cancer experts.
Modern Approach to Diagnosis and Treatment of Bladder Cancer
Bladder cancer is an important topic in the field of urology affecting human overall health and well-being. There have been many advancements in the diagnosis and treatment of bladder cancer, one of the most common carcinomas seen in urology. As such, it is of the utmost importance for urologists and oncologists to have comprehensive and proper knowledge of the disease's diagnostic pathways as well options for its treatment. This book presents the state of the art in diagnosing and treating bladder cancer, including the latest findings on molecular classification of this tumor, chemotherapy, immunotherapy, and minimally invasive techniques for surgical treatment.
Squamous Cell Carcinoma
With the support of multinational specialists, each with different background and separate field of expertise in oncology, this book had the occasion to emerge and to offer physicians, researchers and academics efficient, well-organized and updated scientific information related to the characteristics and treatment modalities of squamous cell carcinoma. It provided in-depth information regarding the comprehension of the molecular interaction of signalling pathways and new phenotypes that might result and lead to further cell proliferation and metastases. It also emphasized on the management and individualization of treatment strategies in different types of SCC, applying molecular profiling ...
Recent Advances in Bone Tumours and Osteoarthritis
This book is a combination of recent advances in two major areas of orthopaedics: Bone tumours and Osteoarthritis. All chapters are contributed by well-known researchers and surgeons in Orthopaedics working across the globe. The book is divided into two major parts for clarity. All authors have contributed their original research, their experience in the field, and the recent advances that will keep the reader well informed and up to date in our understanding of bone tumours and osteoarthritis. This is a 'must have' reference book for any medical library or an individual who is keen to update and have CME (continuous medical education) points added to their learning.
