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The Carbonic Anhydrases
Carbonic anhydrase (CA) is a seemingly ubiquitous enzyme of profound physiological importance, which plays essential roles in respiration, acid-base homeostasis, bone resorption, calcification, photosynthesis, several biosynthetic pathways and a variety of processes involving ion, gas and fluid transfer. This enzyme, which is present in at least three gene families (a, ß, ?), has found favour as a model for the study of evolution of gene families and for site-directed mutagenesis in structure/function relationships, for protein folding and for transgenic and gene target studies. Since the early use of CA inhibitors as diuretics and in treating congestive heart failure, the enzyme has been target of considerable clinical attention. Much of this is now focused on endeavours to produce a new generation of such drugs for the effective treatment of glaucoma and other potential applications. Recent data, suggesting links between CA and various disease processes, including cancer, have stimulated further...
Carbon Dioxide Chemistry
This book derives from a workshop held in Sweden to examine the environmental implications of the dramatic increase in carbon dioxide levels in the atmosphere in the last 50 years and to find ways of mitigating greenhouse gas emissions. This multi-disciplinary approach makes it essential reading not only for chemists but for all engineers, biologists and environmentalists concerned with this crucially important issue.
Advances in Genetics
Advances in Genetics
Cyclic Polymers
Cyclic Polymers (Second Edition) reviews the many recent advances in this rapidly expanding subject since the publication of the first edition in 1986. The preparation, characterisation, properties and applications of a wide range of organic and inorganic cyclic oligomers and polymers are described in detail, together with many examples of catenanes and rotaxanes. The importance of large cyclics in biological chemistry and molecular biology is emphasised by a wide coverage of circular DNA, cyclic peptides and cyclic oligosaccharides and polysaccharides. Experimental techniques and theoretical aspects of cyclic polymers are included, as well as examples of their uses such as ring opening polymerisation reactions to give commercially important materials. This book covers a wide range of topics which should be of interest to many scientific research workers (for example, in polymer science, chemistry and molecular biology), as well as providing a reference text for undergraduate and graduate students.
Silicones and Silicone-modified Materials
This book covers the recent academic and technological developments behind silicones and silicone-modified materials. Silicones are a growing industry, widely used in the polymer industry as elastomers, pressure sensitive adhesives, in water-borne systems, biomedical products, personal care products and electronics encapsulents. The book covers these topics, and more, making it ideal for anyone working in the industry or needing a thorough academic update on silicones.
Carbonic Anhydrase
Carbonic Anhydrase: Its Inhibitors and Activators provides a state-of-the-art overview of the latest developments and challenges in carbonic anhydrase research. Authors describe the mechanisms of action of specific inhibitors in relation to physiological function, and present previously unpublished research on CA activators. Written by a team of in
Neurobiology and Cell Physiology of Chemoreception
This volume records the papers presented in Chieti, Italy, at the 1991 meeting of the International Society for Arterial Chemoreception (ISAC). This was the eleventh of a series of assemblies held since 1959. This field of research, which examines the critical function and mechanisms of O and pHIPC0 sensitive cells in 2 2 the body, is unique in that it encompasses diverse biological and medical areas. The reader of this book will note chapters concerning modem techniques like in situ hybridization; analysis of cell membrane channels and intracellular ion movements; immunohistochemistry of peptides, hormones, and the corresponding receptors of chemoreceptor cells; and systemic analysis of ref...
Homeostasis and Toxicology of Essential Metals
Homeostasis and Toxicology of Essential Metals synthesizes the explosion of new information on the molecular, cellular, and organismal handling of metals in fish in the past 15 years. These elements are no longer viewed by fish physiologists as "heavy metals" that kill fish by suffocation, but rather as interesting moieties that enter and leave fish by specific pathways, which are subject to physiological regulation. The metals featured in this volume are those about which there has been most public and scientific concern, and therefore are those most widely studied by fish researchers. Metals such as Cu, Zn, Fe, Ni, Co, Se, Mo and Cr are either proven to be or are strongly suspected to be essential in trace amounts, yet are toxic in higher doses.
Dynamic Mechanical and Creep-Recovery Behavior of Polymer-Based Composites
Dynamic Mechanical and Creep-Recovery Behaviour of Polymer-Based Composites: Mechanical and Mathematical Modeling covers mathematical modelling, dynamic mechanical analysis, and the ways in which various factors impact the creep-recovery behaviour of polymer composites. The effects of polymer molecular weight, plasticizers, cross-linking agents, and chemical treatment of filler material are addressed and information on thermoplastic and thermosetting polymer-based composites is also covered, including their various applications and the advantages and disadvantages of their use in different settings. The final 2 chapters of the book cover mathematical modeling of creep-recovery behavior for p...
Developmental Neurobiology of Breathing
This monograph provides a comprehensive basis for understanding the complex interactions that take place between synaptic input, cellular properties, and the oscillatory output of a neural network, especially in the maturing or developing nervous system. Emphasis is placed on drawing a parallel betw
