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Polymeric Micelles: Principles, Perspectives and Practices
This book thoroughly reviews the advancements in design and applications of Polymeric Micelles (PMs) in drug delivery. It provides information on the synthesis of amphiphilic block copolymers and their types, functional chemistry for targeting and sensing, and biomedical applications. The book further provides the possibilities for designing PMs in a range of drug delivery approaches. The book addresses the molecular parameters of amphiphilic block copolymers that are required for functionalizing PMs for drug delivery applications. Additionally, the book presents recent advances in applications of PMs such as co-delivery, sensing, theranostics, delivery of nucleic acids, and proteins. Towards the end, it discusses different physico-chemical strategies to enhance the stability and drug retention of polymeric micelles and reviews the preclinical and clinical toxicity and immunogenicity-related aspects of polymeric micelles. This book is an invaluable source for academics, research, and industry professionals working in the field of polymeric micelles and drug delivery.
Traditional Medicines in Drug Discovery and Development
This comprehensive book, comprising 20 chapters contributed by respected academics in their respective fields, highlights the immense contribution of traditional medicine to the discovery and development of modern drugs. Each chapter provides in-depth details, stimulating experts to further explore the flora used in traditional medicines and inspiring younger investigators to delve into the mysterious world of secondary metabolites in their quest for novel molecules. This book is of immense value to scientists, academicians, researchers, and students alike, making it a valuable addition to personal collections and libraries.
Advanced Drug Delivery Systems in the Management of Cancer
Advanced Drug Delivery Systems in the Management of Cancer discusses recent developments in nanomedicine and nano-based drug delivery systems used in the treatment of cancers affecting the blood, lungs, brain, and kidneys. The research presented in this book includes international collaborations in the area of novel drug delivery for the treatment of cancer. Cancer therapy remains one of the greatest challenges in modern medicine, as successful treatment requires the elimination of malignant cells that are closely related to normal cells within the body. Advanced drug delivery systems are carriers for a wide range of pharmacotherapies used in many applications, including cancer treatment. Th...
Nanotherapeutics for the Treatment of Hepatocellular Carcinoma
Hepatocellular carcinoma (HCC) is a leading cause of death globally. Conventional chemotherapeutic agents are unable to penetrate cancerous hepatocytes completely and are toxic to non cancerous cells and tissues. This toxicity significantly compromises the therapeutic outcome of conventional chemotherapeutic agents which is also reflected in the high mortality of the disease. Nanotherapeutics have shed new light onto HCC treatment by enabling site-specific in vivo delivery of chemotherapeutics specifically to neoplastic hepatocytes without affecting normal hepatocytes. Thus, nanotherapeutics have shown considerable potential and there is tremendous impetus for rapid translation from the pre-...
COVID-19: A Multidimensional Response
COVID-19 disease is caused by the SARS-CoV-2 virus, first detected in Wuhan, China in November/December 2019. To date, around 15 million+ people are infected with novel coronavirus around the globe and count is going up every passing day. Even though it causes severe respiratory problems, the majority of patients show mild infections and pathogenesis is under investigation. Several drugs are being re-purposed and many of them are undergoing clinical trials, however, currently, there are no approved drugs/vaccines to cure this disease. In this context, ‘COVID-19 A Multidimensional Response’ is an evolving e-book published by Manipal Universal Press with the initiative and editorship of Dr N Udupa, Dr Raviraja N S and Dr Chiranjay Mukhopadhyay, with excellent scientific contribution of experts in the field. The book is a redemptive exercise in creating awareness with facts and figures about the dreaded disease in these troubled times. The book has the information on history and origin of the disease, pathogenicity, host factors, laboratory diagnosis, management, immunoprophylaxis, and newer advancements in research.
Polymeric nanoparticles for the treatment of solid tumors
This book focuses on the emerging research in the field of treatment of solid tumors or cancer with new drug delivery systems using nanotechnology. Nanotechnology has given us a good scope for development of new innovative drug delivery strategies to increase the therapeutic efficacy of anticancer drugs with reduced off-target side effects. Cancer is one of the main causes of death worldwide due to the limitations of classical therapies such as low solubility of active drugs, toxic side effects on healthy cells and resistance of tumor cells. These issues are partly solved by the recent development of polymeric nanoparticles, which improve drug absorption and the therapeutic index, while redu...
Nasal Drug Delivery
This book addresses the recent trends and clinical research being reported in last 5 to 10 years in the field of nasal drug delivery systems. In recent years, interest in using nasal passage as drug absorption site has received increased attention from formulation scientists. Nasal passages, even though a small surface area of the body as compared to other absorption passage such as Gastrointestinal tract or skin, show significant possibility for drug absorption at a quicker rate. There is also a possibility of delivering drugs to the brain using this passage and targeting drugs through the nasal passage. The book has 19 chapters addressing various aspects of nasal drug delivery systems such...
Quality in Pharmaceutical Education, Research and Practice (vision 2020)
The book discusses the topics related to quality in education and research. It begins with a topic on Good Science, Education, and Teaching. Next chapter on Total Quality Management in pharmacy education highlights the importance of quality pharmacy education. There are focused chapters emphasizing the importance of quality education in pharmaceutics, medicinal chemistry, pharmaceutical biotechnology, pharmaceutical services, and pharmacognosy. The book includes a brief note on scope and potential in pharmacovigilance and quality of pharmaceutical sciences journals.
The Quintessence of Basic and Clinical Research and Scientific Publishing
The book, intended for biomedical researchers, attempts to foster a comprehensive understanding of the elements that impact scientific research, such as clinical trial design, communication, and publication methods. It introduces the process of idea generation and creative/critical thinking, leading to the development of key concepts that coalesce into theoretical constructs and working hypotheses. The book systematically delineates research phases associated with a bench-to-bedside translational approach, providing the full depth and breadth of drug discovery and development: design, synthesis, and optimization of drug candidates interacting with targets linked to diseases, as well as clini...
