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Cerebral and Cerebellar Cortex
Cerebral and Cerebellar Cortex – Interaction and Dynamics in Health and Disease discusses several important issues of cerebro-cerebellar collaboration and interactions. The morphological and functional study of the cerebral and cerebellar cortices and their interaction has considerable value for interpreting the clinical phenomenology of cortical degenerations in the initial stage of the disease. In addition, the analysis of cerebro-cerebellar interactions strongly supports the concept of the close functional unity and harmonization of the brain and the cerebellum, underlining the important role that the cerebellar cortex plays in the performance of higher mental faculties, creativity, emotional processes, and homeostatic equilibrium of the human body.
Mitochondria and Brain Disorders
The mitochondrion is a unique and ubiquitous organelle that contains its own genome, encoding essential proteins that are major components of the respiratory chain and energy production system. Mitochondria play a dominant role in the life and function of eukaryotic cells including neurons and glia, as their survival and activity depend upon mitochondrial energy production and supply. Besides energy production, mitochondria also play a vital role in calcium homeostasis and may induce apoptosis by excitotoxicity. Mitochondrial dysfunction is related to common neurological diseases, such as Parkinson's disease, Alzheimer's disease, Friedreich's ataxia, Huntington's disease, and Multiple Sclerosis. An efficient treatment of mitochondrial dysfunction would open new horizons in the therapeutic perspectives of a substantial number of inflammatory and degenerative neurological disorders.
Cerebral and Cerebellar Cortex
Cerebral and Cerebellar Cortex - Interaction and Dynamics in Health and Disease discusses several important issues of cerebro-cerebellar collaboration and interactions. The morphological and functional study of the cerebral and cerebellar cortices and their interaction has considerable value for interpreting the clinical phenomenology of cortical degenerations in the initial stage of the disease. In addition, the analysis of cerebro-cerebellar interactions strongly supports the concept of the close functional unity and harmonization of the brain and the cerebellum, underlining the important role that the cerebellar cortex plays in the performance of higher mental faculties, creativity, emotional processes, and homeostatic equilibrium of the human body.
Hypothalamus in Health and Diseases
The human hypothalamus, a small structure at the base of the brain, has strategic importance for the harmonic function of the human body. It controls the autonomic nervous system, neuroendocrine function, circadian and circannual rhythms, somatic activities, and behavior, and is situated at the borders between the brain and the body and the brain and the soul, meeting points for mind and body. The hypothalamus is involved in a wide range of higher mental functions, including attention, learning and reinforcement of mnemonic processes, emotional control, mood stability, and cognitive-emotional interactions. It also has a role to play in behavioral disorders, panic reactions, cluster headache, gelastic epilepsy, mental deficiency, periodic disorders, depression, autism, and schizophrenia, and in a substantial number of neurodegenerative diseases. It enlarges greatly the dimensions of the hypothalamic contribution in controlling psychosomatic equilibrium and retaining internal unity of the human existence.
Demyelination Disorders
Demyelination disorders are among the most frequent neurological conditions. Types of these disorders include multiple sclerosis, Guillain Barré syndrome, diabetic peripheral neuropathy, entrapment neuropathies, and others, all of which can result in serious physical incapacity and diminished quality of life. This book examines various aspects of demyelination from clinical, diagnostic, and therapeutic points of view. Chapters address different types of demyelination diseases, their associated mechanisms, and pharmacologic and nonpharmacologic treatment approaches, among other topics.
Adaptation Biology and Medicine
It has become amply clear that all live forms on Earth are the products of the constituent genes expressed under the influence of continuously changing natural environment. By the same token, gene expression is known to be modified by our (or by the modern) environment inclusive of factors such as gravity, altitude, temperature, atmospheric pressure and air quality, physical conditioning as well as nutrition and/or lifestyle. Life would not survive without recruiting endogenous adaptive mechanisms responsive to challenging environmnetal factors, Biology of adaptation as well as application of this knowledge has been discussed in both health and disease conditions such as cardiac ischemia and cardiomyopathies, stroke, dementia, Alzheimer's, cancer, metal toxicity, etc. The book will be of great interest to experimental biologists and health professionals dealing with benefits and failures of physiological and pathophysiological adaptations. It will also serve as an important source of information for young scientists, postdocs and students.
Cognitive Disorders
This book contains selected peer-reviewed chapters that cover novel information on cognitive disorders and updated information on dementias written by international researchers. In this project, we discuss the effect of metabolic disorders on the development of cognitive disorders in patients with type 1 diabetes mellitus. In another chapter, the authors highlight the usability of an assistive software application developed for patients with dementia. On the other hand, an extensive review of novel information on different types of dementia is made. This chapter covers the novel aspect of dementia without ignoring its foundation. Therefore, apart from classic issues that cannot be missed in ...
Multiple Sclerosis
Multiple sclerosis is among the most frequent neurological diseases, which affect seriously the quality of life of a constantly increasing number of patients, inducing physical and mental invalidism with indefinite perspectives. The ongoing investigation of the pathogenetic background and the inconclusive analysis of many pathophysiological mechanisms and serious neuropathological alterations of the disease are dominant crucial topics in the field of neurosciences, aimed at tracing a definite way to a therapeutic approach. The authors of this volume attempt to throw light on the labyrinth of multiple sclerosis, approaching the disease from the viewpoint of epidemiology, autoimmune reactions, symptomatology, mental and physical decline, diagnostic procedures, prognosis, and treatment. The authors submit herein, along with scientific data, their hope of contributing effectively to ameliorating the quality of life of those suffering from multiple sclerosis who wait patiently for the day of recovery.
Frontiers in Clinical Drug Research - Alzheimer Disorders
Frontiers in Clinical Drug Research - Alzheimer Disorders is an e-Book series concerned with Alzheimer's disease (AD) that causes dementia, or loss of brain function. The disease affects the parts of the brain that deal with memory, thought, and language. Chapters in each volume focus on (Alzheimer Disorders) drug research with special emphasis on clinical trials, research on drugs in advanced stages of development and cure for Alzheimer’s disease and related disorders. Frontiers in Clinical Drug Research - Alzheimer Disorders will be of particular interest to readers interested in drug therapy of this specific neurodegenerative condition and related brain disorders as the series provides relevant reviews written by experts in field of Alzheimer’s Disease research.
Neurodegenerative Diseases
This book highlights the pathophysiological complexities of the mechanisms and factors that are likely to be involved in a range of neuroinflammatory and neurodegenerative diseases including Alzheimer's disease, other Dementia, Parkinson Diseases and Multiple Sclerosis. The spectrum of diverse factors involved in neurodegeneration, such as protein aggregation, oxidative stress, caspases and secretase, regulators, cholesterol, zinc, microglia, astrocytes, oligodendrocytes, etc, have been discussed in the context of disease progression. In addition, novel approaches to therapeutic interventions have also been presented. It is hoped that students, scientists and clinicians shall find this very informative book immensely useful and thought-provoking.
