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Dynamic Fleet Management for International Truck Transportation
Two new dynamic planning approaches, incorporating all important real-life restrictions, such as regulations on driving and working hours, are developed and evaluated. Extensive numerical tests are carried out with a five-week real-life data set from an international freight forwarding company.
Operations Research Proceedings 2011
This book contains a selection of refereed papers presented at the “International Conference on Operations Research (OR 2011)” which took place at the University of Zurich from August 30 to September 2, 2011. The conference was jointly organized by the German speaking OR societies from Austria (ÖGOR), Germany (GOR) and Switzerland (SVOR) under the patronage of SVOR. More than 840 scientists and students from over 50 countries attended OR 2011 and presented 620 papers in 16 parallel topical streams, as well as special award sessions. The conference was designed according to the understanding of Operations Research as an interdisciplinary science focusing on modeling complex socio-technical systems to gain insight into behavior under interventions by decision makers. Dealing with “organized complexity” lies in the core of OR and designing useful support systems to master the challenge of system management in complex environment is the ultimate goal of our professional societies. To this end, algorithmic techniques and system modeling are two fundamental competences which are also well-balanced in these proceedings.
Advanced Planning in Supply Chains
Advanced Planning Systems (APS) are a key enabler of the supply chain management. However, APS are highly complex and difficult to comprehend. This book provides students with valuable insights into the capabilities of state-of-the-art APS and bridges the gap between theory (model building and solution algorithms), software implementation, and adaptation to a specific business case. Our business case – named Frutado – provides a unifying framework for illustrating the different planning tasks that arise in a company – from demand planning to the distribution of goods – that are addressed by APS. In addition, the book guides through interactive learning units which have been created and recorded for each module of SAP ́s APS. Learning units can be downloaded free of charge ready to be displayed in a web browser. Together, the textbook and the learning units provide the required skills to better understand the concepts, models, and algorithms underlying today ́s APS.
Analyse und Optimierung der Produktionsglättung für Mehrprodukt-Fließlinien
Die Prinzipien des Toyota-Produktionssystems (kurz: TPS) erhielten in den vergangen Jahren vermehrt Beachtung in der Praxis. Viele Unternehmen, auch außerhalb der Automobilbranche, interessieren sich für die vermeintlich einfachen Vorgehensweisen zur Planung und Steuerung logistischer Abläufe und führen diese ein. Die wissenschaftliche Auseinandersetzung mit dem TPS hingegen ist bisher mangelhaft. Zwar existieren Arbeiten die heuristische Ansätze zur Lösung einzelner Aspekte des TPS vorstellen, doch werden darin die Wechselwirkungen zwischen den Bestandteilen nicht betrachtet. Hier setzt die vorliegende Arbeit an und betrachtet die Wechselwirkung zwischen geglätteter Produktion und de...
Dynamic Fleet Management for International Truck Transportation
Two new dynamic planning approaches, incorporating all important real-life restrictions, such as regulations on driving and working hours, are developed and evaluated. Extensive numerical tests are carried out with a five-week real-life data set from an international freight forwarding company.
Molecular and Clinical Advances in Anticancer Drug Resistance
The importance of drug resistance in cancer chemotherapy cannot be over stated. The 500,000 patients who die every year from cancer in the United States have, in most cases, been treated with chemotherapy. Many of these patients responded initially to chemotherapy, but death resulted from the development of drug-resistant tumors. In the first volume in the series. Drug Resistance in Chemotherapy the results of comprehensive laboratory studies aimed at understanding the mechanisms for resistance to individual agents and to the development of broad cross-resistance were described. In the past 2 years there has been substantial progress in understanding the molecular biology associated with the...
Induced Effects Of Genotoxic Agents In Eukaryotic Cells
This book provides an understanding of the consequences of induced proteins in the toxicological response of cells to chemical and radiation damage to DNA and will be helpful in creating proper mathematical models for extrapolation to low doses and assessing human exposure or cellular injury.
