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This volume foxuses on the status of Ca2+ ions in regulation of phototransduction, light adaptation and the recovery phase in vertebrate photoreceptors. Particular emphasis is given to Ca2+-binding proteins and their targets, among them particulate guanylate cyclases, GPCR-coupled kinases and cyclic nucleotide-gated cation channels. The book also expands our understanding of events invovling Ca2+ in the retinal pigment epithelium, in synaptic transmission and secondary retinal neurons. A significant part of the book is dedicated to the role of Ca2+ in invertebrate phototransduction, the best-studied phospholipid-mediated signal transduction pathway. Several chapters explore association of gene defects with human retina disease and the generation of animal models of retinal degeneration.
Given the very limited capacity of regeneration in the brain, protecting neurons that are on the brink of death is a major challenge for basic and clinical neuroscience, with implications for a broad spectrum of acute and chronic neurological and psychiatric diseases. This book brings together leading experts from neurobiology, neurophysiology, neuropharmacology, neuroimmunology and clinical neuroscience to highlight the most recent milestones in this rapidly evolving field. The book will serve as a reference for both basic neuroscientists and clinicians interested in an authoritative update on the molecular and cellular biology of neuroprotection and its promises for new therapeutic strategies.
In 1996, the National Bladder Foundation (NBF) was founded by a dedicated group of physicians and researchers propeIled by the urgent need to find better treatments for bladder disease. Committed to increasing bladder disease research and to supporting its research community, the NBF coordinates and sponsors the International Bladder Symposium (IBS) in Washington, DC. Now considered to be a premier scientific assembly, the IBS brings together international leaders in bladder disease research to present and discuss their findings. It is the only international conference where all areas of bladder disease research are exclusively covered and where bladder disease researchers are provided with ...
Now in its revised, updated Third Edition, this best-selling reference is designed for quick consultation on problems seen in infants, children, and adolescents. More than 450 problems are covered in the fast-access two-page outline format that makes The 5-Minute Consult Series titles so popular among busy clinicians. The book is organized into five sections--chief complaints, diseases, syndromes, physical findings, and tables.
Concise and practical, the Penn Clinical Manual of Urology is an indispensable guide to the daily practice of urology. This one-volume medical reference book presents the key clinical information you need to diagnose and treat urologic disorders quickly and effectively, featuring brief, well-illustrated chapters and an easy-to-read format. Essential for clinical questions and answers, the Penn Clinical Manual of Urology deserves a place on the bookshelf of not only every urologist, but every provider treating urologic problems. "This is a powerhouse of a textbook ... it punches well above its diminutive size." Reviewed by: Tim Lane, Consultant Urologist, Lister Hospital, March 2015 Find info...
Provides a review of diseases of the small intestine in children, with an emphasis upon a discussion of their causes, clinical manifestations and the newer techniques which are used in diagnosis as well as modern methods of management. The book will be of value to the consultant paediatrician and paediatric surgeon as well as to the paediatric registrar and house officer as a practical guide to their understanding of these diseases. It is also intended for adult physicians, gastroenterologists and surgeons who wish to survey the clinical spectrum of disease of the small intestine in childhood.
The contents of this book are the proceedings of the ACS symposium, "Fumonisins in Food," which was held April 4-6, 1995, at the American Chemical Society National Meeting in Anaheim, CA. This symposi"Qm, which was international in scope, brought together researchers from diverse backgrounds in academia, government, and industry. Thirty-three speakers discussed topics ranging from the analysis offumonisins to toxicology and regulatory aspects. The fumonisins became the spotlight of mycotoxin research in 1988, when re searchers at the South African Medical Research Council isolated and structurally charac terized the fumonisins. Since 1988, there has been an explosion in the numbers of papers dealing with fumonisin-related topics. The interest in the fumonisins has arisen for several reasons. First, fumonisins are found in measurable concentrations in corn grown throughout the world. Second, these compounds have been implicated as the causative agents in a variety of naturally occurring animal diseases. Finally, there is speCUlation that fumonisins may in part be responsible for the high incidence of esophageal cancer in regions of the world in which corn is the staple grain.
Endourology is a dynamic subspecialty involving closed, controlled manipulation within the genitourinary tract. In the past decade the creative efforts of many urologists, radiologists, and engineers have vastly expanded endoscopic technique, to the great benefit of patients with stones, obstruction, cancer, diverticula, cysts, adrenal disease, varices, and diseases of the bladder. This definitive text addresses every aspect of endourologic procedure including methods of access, operative techniques, complications, and postoperative care. The reader is taken, step-by-step, through cutaneous surgery, ureteroscopy, extracorporeal shock wave lithotripsy, laparoscopy, and lower urinary tract procedures. The principles and function of state-of-the-art endourologic instruments are outlined for each procedure. The authorship reads like a Who’s Who in endodurology . The breadth and depth of their experience is evident throughout the text.
"For the blood is the life . . . . "(Deut. 12 :23) " . . . because the blood, in its value as life, makes atonement" (Lev. 17: 11) HemoPhilia is a rare disease, severe hemophilia rarer still, yet the written history of hemophilia extends back over a millennium and a half. In the ancient Middle East, blood and life were coupled. Blood was the primary substance necessary for life, given to God in sacrifice and forbidden as a food to mortals by Levitical law. Blood was essential for rites of purification and consecration. But the flow of blood during menstruation or parturition rendered a woman unclean. The circumcision of a male child required 33 days of "blood purification" by the mother. ' C...
The Tenth International Conference on Intracellular Protein Catabolism was held in Tokyo Japan, October 30-November 3, 1994. under the auspices of the International Committee on Proteolysis (lCOP). ICOP meetings have been held biennially in the USA, Europe, and Japan in turn. The previous three ICOP meetings (7th to 9th) were held in Shimoda, Japan, in 1988. in WildbadKreuth, Germany, in 1990, and in Williamsburg. Virginia, in 1992. Previous meetings were held in resort areas, this was the first meeting held in a large city. Attendance has grown every year so that nearly 400 participants from 19 different countries attended the Tokyo meeting. At the meeting, novel and updated results on the ...