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Insulin Resistance
Diabetes is now one of the major causes of morbidity worldwide. In many cases, the onset of diabetes is progressive, developing via a condition of insulin resistance. This book considers the development of this condition, its consequences and clinical and therapeutic aspects. The book reviews the normal biology of insulin action on glucose, lipids and proteins. It considers the pathological basis for insulin resistance in animal models and humans, and discusses the influence of heredity, dietary factors and exercise. Clinical consequences including dyslipidaemia, hypertension and polycystic ovary syndrome, and therapeutic strategies for treatment are also examined. * Provides an expert review of the phenomenon of insulin resistance * Brings together a host of recent research for the first time * Written by leading experts in biological and clinical research
The Genetics of Obesity
This book provides a comprehensive compilation of the evidence available regarding the role of genetic differences in the etiology of human obesities and their health and metabolic implications. It also identifies the most promising research areas, methods, and strategies for use in future efforts to understand the genetic basis of obesities and their consequences on human health. Leading researchers in their respective fields present contributed chapters on such topics as etiology and the prevalence of obesities, nongenetic determinants of obesity and fat topography, and animal models and molecular biological technology used to delineate the genetic basis of human obesities. A major portion of the book is devoted to human genetic research and clinical observations encompassing adoption studies, twin studies, family studies, single gene effects, temporal trends and etiology heterogeneity, energy intake and food preference, energy expenditure, and susceptibility to metabolic derangements in the obese state. Future directions of research in the field are covered in the book as well.
Genetics of Obesity Syndromes
Obesity is one of the most important contributing factors to disease throughout the world and is an area of great current interest among researchers and clinicians. The genetics of common obesity is complex, and an important thread through this labyrinth is the study of genetic syndromes in which obesity is a major component. By examining the genetic mechanisms of obesity in these syndromes, the authors will shed new light on the genetics of common obesity. This is the first book on this important and exciting new area and addreses both the molecular and clinical features of the obesity syndromes, providing hard-core information for researchers and practical guidelines for clinicians caring for obese patients. The book is divided into three sections: the first covers approaches for assessing and investigating the obese individual; the second describes nondysmorphic, monogenic forms of obesity; and the third documents key, multisystem obesity syndromes with various genetic etiologies. It is as much a reference book as it is a manual and will appeal to clinical geneticists, obesity researchers, endocrinologists, nutritionists, and medical biologists.
Why Calories Don't Count
Calorie information is ubiquitous. On packaged food, restaurant menus and online recipes we see authoritative numbers that tell us the calorie count of what we're about to consume. And we treat these numbers as gospel; counting, cutting, intermittently consuming and, if you believe some 'experts' out there, magically making them disappear. We all know, and governments advise, that losing weight is just a matter of burning more calories than we consume. Here's the thing, however, that most people have no idea about. ALL of the calorie counts that you see everywhere today, are WRONG. In Why Calories Don't Count Dr Giles Yeo, obesity researcher at Cambridge University, challenges the convention...
The Stairlift Ascends ...
Cocooning with her ninety-year-old Aunt is not the life Helen imagined when she came home to Dublin after 30 years in London. Bickering, bitching, masking-up for rare outings, The Stairlift Ascends is a Twitter diary of our time trying to live together, surviving the pandemic: and each other!
The End of Overeating
Uncovers the influences that have conditioned people to overeat, explaining how combinations of fat, sugar, and sa
Genomic medicine
Volume 1 Report also available (ISBN 9780108444517). Genomic medicine has developed from the sequencing of the human genome
Diabetes: Disarming the Silent Killer
Diabetes: Disarming the Silent Killer gathers a prominent group of global researchers who share expert knowledge and views on diabetes. Readers will gain insights into groundbreaking therapies and approaches to preventing and managing diabetes complications. The book, a result of the 3rd Cambridge-Oxford-Sunway Biomedical Symposium, further shares the most recent advances in diabetes research from a Malaysian perspective.
Insulin Action
In 1996 the 75th anniversary of the discovery of insulin was celebrated at the University of Toronto, the scene of that discovery in 1921. This volume was stimulated by the scientific program which was staged at that time and brought together much of the world's best talent to discuss and analyze the most recent developments in our understanding of pancreatic function, insulin secretion, the interaction of insulin with its target tissues, the mechanism of insulin action at the cellular level, and the defects which underlie both Type I (insulin-dependent diabetes mellitus, IDDM) and Type II (noninsulin-dependent diabetes mellitus, NIDDM) forms of the disease. We have chosen to focus the present volume on work related to insulin action.
