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In the genome era, the analysis of gene expression has become a critical requirement in many laboratories. But there has been no comprehensive source of strategic, conceptual, and technical information to guide this often complex task. Transcriptional Regulation in Eukaryotes answers that need. Written by two experienced investigators, Michael Carey and Stephen Smale at the UCLA School of Medicine, and based in part on the Gene Expression course taught at Cold Spring Harbor Laboratory, this book directly addresses all the concerns of a laboratory studying the regulation of a newly isolated gene and the biochemistry of a new transcription factor. This important and unique book is essential reading for anyone pursuing the analysis of gene expression in model systems or disease states.
This invaluable book contains the collected papers of Stephen Smale. These are divided into eight groups: topology; calculus of variations; dynamics; mechanics; economics; biology, electric circuits and mathematical programming; theory of computation; miscellaneous. In addition, each group contains one or two articles by world leaders on its subject which comment on the influence of Smale's work, and another article by Smale with his own retrospective views.
What are the elements of expression? What are the origins, aims, and functions of expression? An adequate theory of expression can help us to address these questions and to recognize the diversity of the many modes of expression (scientific, ethical, aesthetic, religious, and sociocultural). Alex Scott describes the interdependence of the modes of expression, showing that a theory of expression can promote social understanding by illuminating the nature of our interdependence as individuals in society. Expression theory, as described by Scott, is not merely a theory of art. It is a theory of the ethics, aesthetics, psychology, logic, language, and politics of expression. It is a theory that ...
In 1957 Stephen Smale startled the mathematical world by showing that it is possible to turn a sphere inside out without cutting, tearing, or crimping. A few years later, from the beaches of Rio, he introduced the horseshoe map, demonstrating that simple functions could have chaotic dynamics. Despite his diverse accomplishments, Smales name is virtually unknown outside mathematics. One of the objectives of this book is to bring the life and work of this significant figure in intellectual history to the attention of a larger community.
In 2000, the American Mathematical Society published a biography of Professor Stephen Smale, who had recently retired from a prestigious career at the University of California, Berkeley. But in retirement, Professor Smale has continued his academic pursuits through the present day, resulting in numerous additional publications and honors in the past 20+ years. As part of the CityU Legacy Series, this book documents Professor Smale's time at City University of Hong Kong, during his first appointment as a Distinguished University Professor in the Department of Mathematics from 1995-2001 as well as when he returned from 2009-2016. It also covers colorful and adventurous aspects of his life, inc...
A proposal for a new model of the evolution of gene regulation networks and development that draws on work from artificial intelligence and philosophy of mind. Each of us is a collection of more than ten trillion cells, busy performing tasks crucial to our continued existence. Gene regulation networks, consisting of a subset of genes called transcription factors, control cellular activity, producing the right gene activities for the many situations that the multiplicity of cells in our bodies face. Genes working together make up a truly ingenious system. In this book, Roger Sansom investigates how gene regulation works and how such a refined but simple system evolved. Sansom describes in det...
This invaluable book contains the collected papers of Stephen Smale. These are divided into eight groups: topology; calculus of variations; dynamics; mechanics; economics; biology, electric circuits and mathematical programming; theory of computation; miscellaneous. In addition, each group contains one or two articles by world leaders on its subject which comment on the influence of Smale's work, and another article by Smale with his own retrospective views.
The book embodies 22 chapters covering various important disciplines of biotechnology, such as cell biology, molecular biology, molecular genetics, biophysical methods, genomics and proteomics, metagenomics, enzyme technology, immune-technology, transgenic plants and animals, industrial microbiology and environmental biotechnology. The book is illustrative. It is written in a simple language
This book is about dynamical aspects of ordinary differential equations and the relations between dynamical systems and certain fields outside pure mathematics. A prominent role is played by the structure theory of linear operators on finite-dimensional vector spaces; the authors have included a self-contained treatment of that subject.
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