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This book serves as a source of information to facilitate the reading of the literature and the planning of trials. Supplies in one place all the information on this active and complex research topic and may stimulate more research that can lead to more exchanges between the laboratory, the clinical ward and the operating room. Fills the need of surgeons to understand the molecular mechanisms in hepatology. Provides a quick and comprehensive overview.
Myofibroblasts (MFB) are found in most tissues of the body. They have the matrix-producing functions of fibroblasts and contractile properties that are known from smooth muscle cells. Fundamental work of the last decades has shed remarkable light on their origin, biological functions and role in disease. During hepatic injury, they fulfill manifold functions in connective tissue remodeling and wound healing, but overshooting activity of MFB on the other side induces fibrosis and cirrhosis. The present e-book "Liver myofibroblasts" contains 9 articles providing comprehensive information on "hot topics" of MFB. In our opening editorial we provide a short overview of the origin of MFB and their relevance in extracellular matrix formation which is the hallmark of hepatic fibrosis. Thereafter, leading experts in the field share their current perspectives on special topics of (i) MFB in development and disease, ii) their role in hepatic fibrogenesis, and (iii) promising therapies and targets that are suitable to interfere with hepatic fibrosis.
"Tad DeLay is one of the most important and disquieting theorists of consciousness and politics writing today. His work is indispensable." —China Miéville, author of October Capitalism is an ecocidal engine constantly regenerating climate change denial The age of denial is over, we are told. Yet emissions continue to rise while gimmicks, graft, and green- washing distract the public from the climate violence suffered by the vulnerable. This timely, interdisciplinary contribution to the environmental humanities draws on the latest climatology, the first shoots of an energy transition, critical theory, Earth’s paleoclimate history, and trends in border violence to answer the most pressing...
As a naïve undergraduate, Ted Carter has big dreams. Though TV did nothing to prepare him for his role as an educator, it certainly inspired him. Fresh out of college, Ted is ready to impact eager-to-learn minds, just like he witnessed on some of his favorite shows, though preferably someplace other than the tiny community in which he grew up. As summer fades, and September inches closer, he reluctantly accepts the only job he’s offered: a sixth grade teaching position in his hometown of Coleman, a small, quiet village tucked away in the hills of northern Michigan. A wild ride of unexpected trials and awkward moments as a raw first-year teacher ensues. Besides the rigors of being a first-...
"This Dover edition, first published in 2013, is an unabridged republication of the work originally published in 1969 by Grosset and Dunlap, New York."
Alcohol is one of the major risk factors for negative health outcomes worldwide. It accounts for more than 60 alcohol-related diseases, ranging from addiction, through liver cirrhosis, to cancer. Collectively, these conditions account for mortality and morbidity that make alcohol use one of the leading preventable causes of disability adjusted life-years (DALYs) lost globally. In this book, an international faculty covers all aspects of alcohol-related disorders, ranging from addiction/alcohol use disorders (AUD) to alcohol-related diseases of other organs such as liver, heart or cancer. A special focus is to reach out to primary care physicians who are in the front line of this major health...
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This book provides an accessible yet rigorous introduction to topology and homology focused on the simplicial space. It presents a compact pipeline from the foundations of topology to biomedical applications. It will be of interest to medical physicists, computer scientists, and engineers, as well as undergraduate and graduate students interested in this topic. Features: Presents a practical guide to algebraic topology as well as persistence homology Contains application examples in the field of biomedicine, including the analysis of histological images and point cloud data