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NMR Primer
"This book has one aim: to explain the key two-dimensional protein NMR experiment, the 1H,15N-HSQC, along with variants and extensions, in a generally accessible manner. Vector diagrams of one-, two- and three-dimensional pulse sequences are provided, along with accompanying animated versions. The animations allow the evolution of net magnetisation during the course of the experiments to be visualised and directly compared with the corresponding spin operator terms. First, a brief introduction to spins, populations, the NMR experiment and relaxation is provided. Evolution due to J-coupling is next described and used to explain magnetisation transfer in the HSQC experiment and several variants. The extraction of structural, sequential and dynamic information is then illustrated via various extensions of the HSQC. Extensive footnotes and appendices introduce several more advanced concepts, such as sensitivity enhancement and the TROSY effect."--Publisher's description.
NMR as a Structural Tool for Macromolecules
The contemplation of truth and beauty is the proper object for which we were created, which calls forth the most intense desires of the soul, and of which it never tires -Hazlitt In his Nobel lecture Purcell commented that when he saw snow in New England after the discovery of NMR, it appeared like "heaps of protons quietly precessing in earth's magnetic field. " If he were to make the comment in the context of how NMR is being used today, he could have conjured up an image of hydrogen, carbon, and nitrogen nuclei in proteins of an earthbound 8rganism subtly orchestrating a quiet symphony of frequencies, from 150 Hz to 2 kHz, carrying clues to the three-dimensional structure of the macromole...
Biomolecular NMR Spectroscopy
Nuclear Magnetic Resonance (NMR) spectroscopy is the most powerful technique for characterization of biomolecular structures at atomic resolution in the solution state. This timely book, entitled "Biomolecular NMR Spectroscopy," focuses on the latest state-of-the-art NMR techniques for characterization of biological macromolecules in the solid and solution state. The editors, Dr. Andrew Dingley (University of Auckland, New Zealand) and Dr. Steven Pascal (Massey University, New Zealand) have organized the book into four sections, covering the following topics: sample preparation, structure and dynamics of proteins, structure and dynamics of nucleic acids and protein-nucleic acid complexes, and rapid and hybrid techniques--
The Paradox of Love
"The sexual revolution is justly celebrated for the freedoms it brought - birth control, the decriminalization of abortion, the liberalization of divorce, greater equality between the sexes, women's massive entry into the workforce, and more tolerance of homosexuality. ...Bruckner argues that our new freedoms have brought new burdens and rules - without, however, wiping out the old rules, emotions, desies and arrangements: the couple, marriage, jealousy, the demand for fidelity, the war between constancy and inconstancy. It is no wonder that love, sex, and relationships today are so confusing, so difficult, and so paradoxical. Drawing on history, politics, psychology, literature, pop culture...
The Wisdom of Money
Money is an evil that does good, and a good that does evil. It is wise to have money, says Pascal Bruckner, and wise to think and talk about it critically. One of the world’s great essayists guides us through the commentary that money has generated since ancient times, as he builds an unfashionable defense of the worldly wisdom of the bourgeoisie.
The Question of God
This invaluable text introduces the six great arguments for the existence of God. It requires no specialist knowledge of philosophy and includes a wealth of primary sources from classic and contemporary texts.
Steven's Bride
When her mother receives a job offer in London, Cara and Steven consider getting married so Cara won't have to go along.
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Perpetual Euphoria
How happiness became mandatory—and why we should reject the demand to "be happy" Happiness today is not just a possibility or an option but a requirement and a duty. To fail to be happy is to fail utterly. Happiness has become a religion—one whose smiley-faced god looks down in rebuke upon everyone who hasn't yet attained the blessed state of perpetual euphoria. How has a liberating principle of the Enlightenment—the right to pursue happiness—become the unavoidable and burdensome responsibility to be happy? How did we become unhappy about not being happy—and what might we do to escape this predicament? In Perpetual Euphoria, Pascal Bruckner takes up these questions with all his unc...
Spirit and Nature
Jansenism, the view of the world as dark and fallen, enjoyed its heyday in 17th century Europe. Radner explores Jansenism and its response to purported miraculous events, exploring the interior logic and its implications for Christian pneumatology.
