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Phospholipases in Physiology and Pathology
Phospholipases in Physiology and Pathology presents a comprehensive overview on the physiology and pathology of phospholipases. This seven-volume set considers the biochemical and molecular mechanisms of normal and abnormal cell function upon dysregulation of phospholipases in different diseases. Volumes cover signal transduction mechanisms, implications in cancer, infectious diseases, neural diseases, cardiovascular diseases and other diseases, implications in inflammation, apoptosis, gene expression and non-coding RNAs, the role of natural and synthetic compounds, and stem cell therapies, nanotechnology-based therapies, and more. Together, these volumes give researchers critical insight on the mechanistic and therapeutic aspects of phospholipases. - Discusses the biochemical and molecular mechanisms of normal and abnormal cell function in different disease processes - Covers a wide range of basic and translational research appropriate for scientists engaged in studying the regulation of phospholipases from interdisciplinary perspectives - Features state-of-the-art chapter contributions from international leaders in the field
Fighting Australia’s Cold War
In the first two decades of the Cold War, Australia fought in three conflicts and prepared to fight in a possible wider conflagration in Southeast Asia and the Pacific. In Korea, Malaya and Borneo, Australian forces encountered new types of warfare, integrated new equipment and ideas, and were part of the longest continual overseas deployments in Australia’s history. Working closely with its allies, Australia also trained for a large conventional war in Southeast Asia, while a significant percentage of the defence force guarded the Papua New Guinea–Indonesian border. At home, the Defence organisation grappled with new threats and military expansion, while the Australian Security Intellig...
Molecular Oncology
Reviews the origins of molecular oncology, including technologies for cancer analysis, key pathways in human malignancies, and available pharmacologic therapies.
The Sickroom in Victorian Fiction
The cultural and narrative significance of illness, nursing and the sickroom in Victorian literature.
The Less Noble Sex
Physically frail, badly educated girls, brought up to lead useless lives as idle gentlewomen, married to dominant husbands, and relegated to "separate spheres" of life—these phrases have often been used to describe Victorian upper-middle-class women. M. Jeanne Peterson rejects such formulations and the received wisdom they embody in favor of a careful examination of Victorian ladies and their lives. Focusing on a network of urban professional families over three generations, this book examines the scope and quality of gentlewomen's education, their physical lives, their relationship to money, their experience of family illness and death, and their relationships to men (brothers and friends as well as fathers and husbands). Peterson also examines the prominent place of work in the lives of these "leisured" Victorian ladies, both single and married. Far from idle, the mothers, wives, and daughters of Victorian clergymen, doctors, lawyers, university dons, and others were accomplished and productive members of society who made substantial public and private contributions to virtually every sphere of Victorian life.
The Impact of Tumor Biology on Cancer Treatment and Multidisciplinary Strategies
Te rapidly changing concepts in radiation oncology with the development of more precise - strumentation for delivery of radiation therapy and a greater emphasis on hypofractionation technologies require a very intimate knowledge of tumor biology and the infuence of various biologic factors on dose distribution within the tumor in terms of homogeneity as well as prev- tion of any late efects on normal tissue surrounding the tumor itself. Not only are these major factors in clinical practice but also the known factors of inhomogeneity of cancer cells, the impact of microenvironment in terms of radiation efect, and host factors make it mandatory to design therapeutic strategies to improve the o...
The Essence of Invention
Meet the brilliant mavericks who invented the future of medicine and saved the lives of millions. The Essence of Invention tells the story of medical invention, from the development of anesthesia and safe surgery, through to the advent of vaccines against smallpox, polio, and Covid-19, that have changed the very foundation of patient care. Dr. Kieran Murphy, a renowned neuroradiologist and inventor in his own right, captures the mind of the inventor — their turmoil, their persistence, their rejection by their peers — and how a small percentage are eventually recognized. The same kind of energy that drove van Gogh or the Beatles can manifest in medicine as inventiveness and the creation o...
