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Aging of Cells in and Outside the Body
This book provides updated knowledge on the basic features and mechanisms of cellular aging established since its first manifestation at cellular level 40 years ago. Contributions of genetic and environmental factors, failure of genetic and cellular repair mechanisms, and the epigenetic modifications determine the final lifespan of cells. This book also provides an understanding on how aging mechanisms in mice, a most frequently used model, differ with that of humans who receive better tumor surveillance because of stringent controls on aging mechanisms. It also appraises the use of modern technology for aging studies and its intervention. This book serves as an excellent reading on cellular aging for undergraduate students, researchers and experts of this area.
Heat Shock Proteins in Cancer
Heat shock proteins are emerging as important molecules in the development of cancer and as key targets in cancer therapy. These proteins enhance the growth of cancer cells and protect tumors from treatments such as drugs or surgery. However, new drugs have recently been developed particularly those targeting heat shock protein 90. As heat shock protein 90 functions to stabilize many of the oncogenes and growth promoting proteins in cancer cells, such drugs have broad specificity in many types of cancer cell and offer the possibility of evading the development of resistance through point mutation or use of compensatory pathways. Heat shock proteins have a further property that makes them tempting targets in cancer immunotherapy. These proteins have the ability to induce an inflammatory response when released in tumors and to carry tumor antigens to antigen presenting cells. They have thus become important components of anticancer vaccines. Overall, heat shock proteins are important new targets in molecular cancer therapy and can be approached in a number of contrasting approaches to therapy.
Ancient and Traditional Foods, Plants, Herbs and Spices used in Diabetes
The use of different foods, herbs, and spices to treat or prevent disease has been recorded for thousands of years. Egyptian papyrus, hieroglyphics and ancient texts from the Middle East have described the cultivation and preparations of herbs and botanicals to “cure the sick.” There are even older records from China and India. Some ancient scripts describe the use of medicinal plants which have never been seen within European cultures. Indeed, all ancient civilizations have pictorial records of different foods, herbs, and spices being used for medical purposes. However, there are fundamental issues pertaining to the scientific evidence for the use of these agents or their extracts in mo...
Biogerontology
Biological aging and interventionary strategies are investigated with the eventual goal of extending healthy human lifespan and minimizing the incidence of diseases associated with aging. Biogerontologists, evolutionary biologists, biodemographers, scientists in related basic research, clinicians, and dieticians came together in Istanbul, Turkey, to share their research and discuss the latest developments in this rapidly advancing field. This volume presents chapters representative of the highlights of the meeting, including contributions in the following areas: (1) biological and nonbiological factors affecting lifespan and the quality of life; (2) ethical and social issues related to lifes...
Cell Immortalization
The problem of the long-term proliferation of cells is a seminal one. It has always been a hot subject in biology, a source of far-reaching hypotheses, even more so now when explanations for the mechanisms of cell prolifera tive mortality or immortality seem within our reach. A question which is still debated is whether an infinite division potential can be a normal trait or is always the result of modifications leading to abnormal cell growth and escape from homeostasis. In general, investigators have been advocates of one of the two extremes, universal limited or unlim ited normal proliferative potential. Since the long-term proliferative potential of cells concerns regulation of development, regeneration of tissues, and homeostatic control of cell growth, in brief survival of living organisms, and since the regulation of these processes is so different along the evolutionary scale, it is not surpris ing that there does not seem to be any universal trait. The question of whether cells are endowed with finite or infinite prolifera tive phenotypes has to be seen using the perspective of comparative biology.
14000 + Objective Questions - General Studies
Arihant has come up with a revised edition of a compendium of over 14000 questions which will significantly improve the knowledge of aspiring students by providing them with ready and reliable practice material for General Studies. The book has been designed for the apsirants preparing for IAS (CSAT), State PCS, CDS, NDA and other competitive examinations.The revised edition of this question bank focuses on Indian History & Culture, India & World Geography (Env & Eco), Indian Polity, Indian Economy, General Science, Science & Technology, General Knowledge and Current Affairs. The book contains the collection of over 14000 questions covering General Studies. The History section covers ancient...
Biological Aging
This book investigates the various processes that are affected by the age of an organism. Several new tools for the analysis of biological aging have been introduced recently, and this volume provides methods and protocols for these new techniques in addition to its coverage of established procedures. Researchers seeking new technology and techniques will find this volume of tremendous benefit as they move towards new directions.
Modulating Aging and Longevity
After decades of systematic collection of data describing age-related changes in organisms, organs, tissues, cells and macromolecules, biogerontologists are now in a position to construct general principles of ageing and explore various possibilities of intervention using rational approaches. While not giving serious consideration to the claims made by charlatans, it cannot be ignored that several researchers are making genuine attempts to test and develop various means of intervention for the prevention and treatment of age-related diseases, for regaining the functional abilities and for prolonging the lifespan of experimental organisms. This book provides the most up-to-date information and a critical evaluation of a variety of approaches being tried for modulating aging and longevity, including dietary supplementation with antioxidants, vitamins and hormones, genetic engineering, life-style alterations, and hormesis through mild stress. The goal of research on ageing is not to increase human longevity regardless of the consequences, but to increase active longevity free from disability and functional dependence.
Aerogel
What Is Aerogel ‘Aerogel’ is a broad term used to talk about an extraordinary group of materials that have been used since the 1960s in space travel but are now finding uses across a whole range of industries. ‘Aerogel’ is not a specific mineral or material with a set chemical formula-rather, the term is used to encompass all materials with a specific geometrical structure. This structure is an extremely porous, solid foam, with high connectivity between branched structures of a few nanometres across. Though aerogel is technically a foam, it can take many different shapes and forms. The majority of aerogel is composed of silica, but carbon, iron oxide, organic polymers, semiconductor...
Brain Aging and Therapeutic Interventions
This book brings together most up-to-date information on different aspects of brain aging and on the strategies for intervention and therapy of age-related brain disorders. It includes 18 chapters by leading researchers, and each chapter is a comprehensive and critical review of the topic in question, discusses the current scenario and focuses on future perspectives. The target readership is the undergraduate and graduate students in the universities, in medical and nursing colleges, along with the post-graduate researchers and practicing clinicians who would like to know about the latest developments in the field of neurodegenerative disorders and their therapeutic interventions. This book will be of much interest to pharmaceutical, nutrition and healthcare industry for an easy access to accurate and reliable information in the field of aging research and intervention.
