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Optimal Control Applied to Biological Models
From economics and business to the biological sciences to physics and engineering, professionals successfully use the powerful mathematical tool of optimal control to make management and strategy decisions. Optimal Control Applied to Biological Models thoroughly develops the mathematical aspects of optimal control theory and provides insight into the application of this theory to biological models. Focusing on mathematical concepts, the book first examines the most basic problem for continuous time ordinary differential equations (ODEs) before discussing more complicated problems, such as variations of the initial conditions, imposed bounds on the control, multiple states and controls, linea...
Complexities
Sophie Germain taught herself mathematics by candlelight, huddled in her bedclothes. Ada Byron Lovelace anticipated aspects of general-purpose digital computing by more than a century. Cora Ratto de Sadosky advanced messages of tolerance and equality while sharing her mathematical talents with generations of students. This captivating book gives voice to women mathematicians from the late eighteenth century through to the present day. It documents the complex nature of the conditions women around the world have faced--and continue to face--while pursuing their careers in mathematics. The stories of the three women above and those of many more appear here, each one enlightening and inspiring....
Mathematics for the Life Sciences
An accessible undergraduate textbook on the essential math concepts used in the life sciences The life sciences deal with a vast array of problems at different spatial, temporal, and organizational scales. The mathematics necessary to describe, model, and analyze these problems is similarly diverse, incorporating quantitative techniques that are rarely taught in standard undergraduate courses. This textbook provides an accessible introduction to these critical mathematical concepts, linking them to biological observation and theory while also presenting the computational tools needed to address problems not readily investigated using mathematics alone. Proven in the classroom and requiring o...
An Introduction to Systems Biology
Thorough and accessible, this book presents the design principles of biological systems, and highlights the recurring circuit elements that make up biological networks. It provides a simple mathematical framework which can be used to understand and even design biological circuits. The textavoids specialist terms, focusing instead on several well-studied biological systems that concisely demonstrate key principles. An Introduction to Systems Biology: Design Principles of Biological Circuits builds a solid foundation for the intuitive understanding of general principles. It encourages the reader to ask why a system is designed in a particular way and then proceeds to answer with simplified models.
Markov Models & Optimization
This book presents a radically new approach to problems of evaluating and optimizing the performance of continuous-time stochastic systems. This approach is based on the use of a family of Markov processes called Piecewise-Deterministic Processes (PDPs) as a general class of stochastic system models. A PDP is a Markov process that follows deterministic trajectories between random jumps, the latter occurring either spontaneously, in a Poisson-like fashion, or when the process hits the boundary of its state space. This formulation includes an enormous variety of applied problems in engineering, operations research, management science and economics as special cases; examples include queueing sy...
Meta-analysis and Combining Information in Genetics and Genomics
Novel Techniques for Analyzing and Combining Data from Modern Biological StudiesBroadens the Traditional Definition of Meta-AnalysisWith the diversity of data and meta-data now available, there is increased interest in analyzing multiple studies beyond statistical approaches of formal meta-analysis. Covering an extensive range of quantitative infor
Exactly Solvable Models of Biological Invasion
Much of our current knowledge on biological invasion was derived from field studies, but many recent advances relied heavily on mathematics and computing, particularly mathematical modeling. While numerical simulations are clearly a useful approach, they have some serious drawbacks. Approximations errors and the number of parameter values can have a significant impact on the simulation results, the extent of which often remains obscure. Such difficulties do not arise, however, when the problem can be solved analytically. Exactly Solvable Models of Biological Invasion demonstrates the advantages and methods of obtaining exact solutions of partial differential equations that describe nonlinear...
Mathematical Modeling the Life Sciences
The purpose of this unique textbook is to bridge the gap between the need for numerical solutions to modeling techniques through computer simulations to develop skill in employing sensitivity analysis to biological and life sciences applications. The underpinning mathematics is minimalized. The focus is on the consequences, implementation, and application. Historical context motivates the models. An understanding of the earliest models provides insight into more complicated ones. While the text avoids getting mired in the details of numerical analysis, it demonstrates how to use numerical methods and provides core codes that can be readily altered to fit a variety of situations. Numerical sc...
Computational Biology
Quantitative methods have a particular knack for improving any field they touch. For biology, computational techniques have led to enormous strides in our understanding of biological systems, but there is still vast territory to cover. Statistical physics especially holds great potential for elucidating the structural-functional relationships in biomolecules, as well as their static and dynamic properties. Breaking New Ground Computational Biology: A Statistical Mechanics Perspective is the first book dedicated to the interface between statistical physics and bioinformatics. Introducing both equilibrium and nonequilibrium statistical mechanics in a manner tailored to computational biologists...
Normal Mode Analysis
Rapid developments in experimental techniques continue to push back the limits in the resolution, size, and complexity of the chemical and biological systems that can be investigated. This challenges the theoretical community to develop innovative methods for better interpreting experimental results. Normal Mode Analysis (NMA) is one such technique
