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Advances in Cancer Research
Advances in Cancer Research
Intratumor Diversity and Clonal Evolution in Cancer
This specialized volume of Advances in Cancer Research is dedicated to the complex and largely unexplored field of intratumor diversity, with respect to differences in both genotype and phenotype among cell populations within tumors. - Unique subject matter: there are relatively few previous publications covering this complex topic, even though it has been a matter of much speculation ever since cancers were first studied under the microscope more than a century ago. This volume is an attempt to update the reader on novel findings as well as giving a historical perspective to the field. It thereby offers an excellent starting point for young scientists entering this field of research - Contributors: many of the contributors are renowned cancer researchers with long-term experience. To bring in new ideas to the field, these experienced authors have been blended with young bright minds who might provide novel starting points for solving old problems - Technical aspects: some chapters will be focused on specific techniques to address intratumor diversity and will therefore be helpful for colleagues wanting to broaden their technical expertise
The AGT Cytogenetics Laboratory Manual
Cytogenetics is the study of chromosome morphology, structure, pathology, function, and behavior. The field has evolved to embrace molecular cytogenetic changes, now termed cytogenomics. Cytogeneticists utilize an assortment of procedures to investigate the full complement of chromosomes and/or a targeted region within a specific chromosome in metaphase or interphase. Tools include routine analysis of G-banded chromosomes, specialized stains that address specific chromosomal structures, and molecular probes, such as fluorescence in situ hybridization (FISH) and chromosome microarray analysis, which employ a variety of methods to highlight a region as small as a single, specific genetic seque...
Focus on Breast Cancer Research
Breast cancer is a malignant tumour that has developed from cells of the breast. A malignant tumor is a group of cancer cells that may invade surrounding tissues or spread (metastasize) to distant areas of the body. The disease occurs almost entirely in women, but men can get it as well. The main types of breast cancer are ductal carcinoma in situ, invasive ductal carcinoma, lobular carcinoma in situ, invasive lobular carcinoma, medullary carcinoma, and Paget's disease of the nipple. About 1 of 8 women will get it in her lifetime. This new book presents state-of-the-art research in this fast-moving field.
Pathology and Genetics of Tumours of Soft Tissue and Bone
This vol. was produced in collaboration with the International Academy of Pathology (IAP).
Cancer Cytogenetics
Cancer Cytogenetics, 3rd Edition, offers a comprehensive, expanded, and up-to-date review of recent dramatic advances in this area and incorporates a vast amount of new data from the latest basic and clinical investigations. Edited by two leading experts, and now involving a new panel of international experts, the book offers an authoritative description of neoplastic processes at the chromosomal level of genomic organization. Researchers in cytogenetics, medical and molecular genetics, cellular and molecular biology, cancer research, clinical oncology, and hematology will find this reference both thorough and authoritative.
Human Cytogenetic Cancer Markers
Seventeen cutting-edge chapters review both basic research and clinical applications of chromosomal markers of cancer. The new markers offer great promise, not only for their clinical utility in diagnosis, prognosis, and disease monitoring, but also for their contributions to a better understanding of the mechanisms of tumor development and progression. The chapters-all written by leading authorities-skillfully reveal fresh insights into the translational role of cytogenetics in identifying the cellular and molecular changes that occur in cancer. Coverage is devoted to many tissue systems-colon, breast, prostate, lung, skin, brain, and kidney-where the diagnostic and prognostic utility of chromosome markers is clearly demonstrated. A seminal book certain to become the front-line reference and authoritative resource needed by all scientists and clinicians engaged in cancer research, diagnosis, and management.
Abnormal Chromosomes
Explore the past, present, and future of cancer cytogenetics In Abnormal Chromosomes: The Past, Present, and Future of Cancer Cytogenetics, globally renowned researchers Drs. Sverre Heim and Felix Mitelman deliver a state-of-the-art review of how cancer cytogenetic analyses have contributed to an improved understanding of tumorigenesis as well as to the diagnosis and treatment of cancer patients. The book also discusses how cytogenetics – the study of chromosomes - meets, interacts with, and cross-fertilizes other investigative technologies, including molecular somatic cell genetics. The book provides an impetus to think more deeply about the role chromosomes, and their abnormalities, play...
