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T Cell Regulation in Allergy, Asthma and Atopic Skin Diseases
This book presents the state of the art in cellular and molecular mechanisms regulating the immune response in allergic inflammation. Special attention is given to the central role of regulatory T cells (Treg) in immune regulation and induction of peripheral tolerance, as well as to the relevance of Th17 cells in chronic inflammation. The importance of Treg and Th17 cells is demonstrated in bronchial asthma, atopic eczema, contact dermatitis and delayed-type hypersensitivity. Furthermore, T-cell-mediated regulatory mechanisms in helminthic infections and fungal allergy are discussed. Several chapters are devoted to the therapeutic consequences that these recently discovered T-cell functions ...
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Chronic Myeloproliferative Disorders
With the new classification of chronic myeloproliferative disorders, and the rise of interest in molecularly targeted therapies, this timely text brings together international experts on the topic to discuss the current technologies and their implications for the treatment of patients. This title comprehensively covers chronic myeloid leukemia and Ph-negative chronic myeloproliferative disorders and is an essential resource for all practitioners in Hematologic Oncology.
Sociological Abstracts
CSA Sociological Abstracts abstracts and indexes the international literature in sociology and related disciplines in the social and behavioral sciences. The database provides abstracts of journal articles and citations to book reviews drawn from over 1,800+ serials publications, and also provides abstracts of books, book chapters, dissertations, and conference papers.
Graph Spectra for Complex Networks
Analyzing the behavior of complex networks is an important element in the design of new man-made structures such as communication systems and biologically engineered molecules. Because any complex network can be represented by a graph, and therefore in turn by a matrix, graph theory has become a powerful tool in the investigation of network performance. This self-contained 2010 book provides a concise introduction to the theory of graph spectra and its applications to the study of complex networks. Covering a range of types of graphs and topics important to the analysis of complex systems, this guide provides the mathematical foundation needed to understand and apply spectral insight to real-world systems. In particular, the general properties of both the adjacency and Laplacian spectrum of graphs are derived and applied to complex networks. An ideal resource for researchers and students in communications networking as well as in physics and mathematics.
Steeltown, USSR
No one, not even Mikhail Gorbachev, anticipated what was in store when the Soviet Union embarked in the 1980s on a radical course of long-overdue structural reform. The consequences of that momentous decision, which set in motion a transformation eventually affecting the entire postwar world order, are here chronicled from inside a previously forbidden Soviet city, Magnitogorsk. Built under Stalin and championed by him as a showcase of socialism, the city remained closed to Western scrutiny until four years ago, when Stephen Kotkin became the first American to live there in nearly half a century. An uncommonly perceptive observer, a gifted writer, and a first-rate social scientist, Kotkin of...
Treatment of Autoimmune Disorders
Progress in basic and clinical immunology within the last two decades has provided profound insight into the immune system and its role in preventing endogenous and exogenous damage. In contrast, disbalances within this system can result in autoimmune disorders which may affect diverse organs and result in distinct clinical pictures. In many of these, however, the individual etiopathogenetic mechanisms are poorly understood and even more their clinical symptoms are hard to treat. The book offers insight into basic mechanisms of autoimmune disorders. It includes neurological, gastrointestinal, ophthalmological and skin diseases as well as current and future therapeutic options including immunomodulatory drugs and different vaccination strategies. By addressing diverse organ systems, both singular and shared features are elaborated. Thus an exchange of ideas is intended across research on single organ systems within a truly interdisciplinary setting.
