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Gerontorheumatology
This book covers all aspects of the specialized field of gerontorheumatology, providing a complete overview of rheumatic and musculoskeletal diseases and related conditions in the elderly. The emphasis is particularly on pathogenesis, diagnosis, prevention, and treatment, including the latest advances in biological and pharmacological therapy and potential treatment side effects. The book will provide the reader with a keen awareness of the characteristic features, distinctive etiologies, and different courses of the various disorders of the musculoskeletal system in the geriatric population. Diagnostic and treatment considerations of special relevance in daily practice are highlighted, and the importance of comorbidities and their rheumatic consequences is also emphasized. The book will be of value for gerontologists, rheumatologists, internists, and rehabilitation physicians and will offer excellent guidance for general practitioners, who are typically the first to deal with disorders of the musculoskeletal system in elderly patients.
Cerebrospinal Fluid Biomarkers
This volume covers the latest methods used in clinical neurochemistry laboratories for both clinical practice and research. Chapters in this book discuss topics such as techniques for cerebrospinal fluid (CSF) collection, pre-analytical processing, and basic CSF analysis; an examination of biomarkers including ELISA and automated immunochemical assays for amyloid and tau markers for Alzheimer’s disease; the analysis of neurofilaments by digital ELISA; and an example of successful novel immunoassay development. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Cutting-edge and thorough, Cerebrospinal Fluid Biomarkers is a valuable resource for clinicians and researchers to use in CSF labs and CSF courses.
Violence, Conflict and Discourse in Mexican Cinema (2002-2015)
The last two decades have seen dramatic changes to Mexico’s socio-political landscape. A former president fleeing into exile, political assassinations, a rebellion in Chiapas, and the eruption of the so-called war on drugs provide key examples of critical events shaping the nation. This book examines Mexican cinema’s representations of, and responses to, these socio-political moments. Beginning with the definitive year 1994, which saw the Ejército Zapatista de Liberación Nacional (EZLN) declare war on the Mexican government, the early chapters in this book discuss the outcome of these episodes in subsequent years and how they find screen representation. The study then moves on to provi...
Neuro-Geriatrics
This manual takes a multidisciplinary approach to neurological disorders in the elderly. Comprehensive and practical, it includes the most recent diagnostic criteria and immediately accessible visual care paths including the latest pharmacologic and non-pharmacologic interventions. Covering a range of modalities, from the importance and impact of each disease to diagnostic criteria, genetics, laboratory and imaging findings, treatment and care paths, this book focuses on neurological conditions that occur commonly in older persons or which have a striking effect on their lives. The common types of dementias, Parkinson’s disease and related disorders, rapidly progressive diseases, seizure disorders and multiple sclerosis are covered. Issues commonly affecting this population, such as neurobehavioral symptoms and caregiver issues, are discussed. Neuro-Geriatrics: A Clinical Manual is aimed at any physician who treats the elderly with neurological disorders: neurologists, geriatricians and geriatric psychiatrists, both specialists and general practitioners.
Generalised Anxiety Disorder in Adults
This guideline is an update of NICEs previous guidance on generalised anxiety disorder (GAD). It reviews the evidence for low- and high-intensity psychological interventions and drug treatments, and also gives an insight into the experience of care of people with GAD, which is a common mental health problem and often co-occurs with other anxiety and depressive disorders. RCPsych Publications is the publishing arm of the Royal College of Psychiatrists (based in London, United Kingdom), which has been promoting excellence in mental health care since 1841. Produced by the same editorial team who publish The British Journal of Psychiatry, they sell books for both psychiatrists and other mental health professionals; and also many written for the general public. Their popular series include the College Seminars Series, the NICE mental health guidelines and the Books Beyond Words series for people with intellectual disabilities.
Drug Discovery and Development, Volume 1
From first principles to real-world applications -- here is the first comprehensive guide to drug discovery and development Modern drug discovery and development require the collaborative efforts of specialists in a broadarray of scientific, technical, and business disciplines--from biochemistry to molecular biology, organic chemistry to medicinal chemistry, pharmacology to marketing. Yet surprisingly, until now, there were no authoritative references offering a complete, fully integrated picture of the process. The only comprehensive guide of its kind, this groundbreaking two-volume resource provides an overview of the entire sequence of operations involved in drug discovery and development...
Target Discovery and Validation
The modern drug developers? guide for making informed choices among the diverse target identification methods Target Discovery and Validation: Methods and Strategies for Drug Discovery offers a hands-on review of the modern technologies for drug target identification and validation. With contributions from noted industry and academic experts, the book addresses the most recent chemical, biological, and computational methods. Additionally, the book highlights techologies that are applicable to ?difficult? targets and drugs directed at multiple targets, including chemoproteomics, activity-based protein profiling, pathway mapping, genome-wide association studies, and array-based profiling. Thro...
Print Culture and Peripheries in Early Modern Europe
Despite the fact that, if only by number, small and peripheral cities played an important role in fifteenth and sixteenth-century European print culture, book history has mainly been dominated by monographs on individual big book centres. Through a number of specific case studies, which deploy a variety of methods and a wide range of sources, this volume seeks to enhance our understanding of printing and the book trade in small and peripheral European cities in the fifteenth and sixteenth centuries, and to emphasize the necessity of new research for the study of print culture in such cities.
Minimalist Interiors
Drawing from cultural developments as diverse as modernist art and Asian philosophy, minimalism in interior design is nothing less than a celebration of the perfect expression of space. Minimalist Interiors presents 26 examples of residences from around the world that perfectly balance essential elements of shape, light, and form to create truly unique living spaces. From a glass house to a house without walls, from an extention of a single-family home to apartment renovations, this book presents solutions and ideas for all types of residences. Interiors for every room in the house are included, in varying sizes, all from well-known architects and designers who specialize in minimalist treatment Through exquisite photography, technical plans, and innovative design, Minimalist Interiors will inspire home design enthusiasts to achieve the same effects -- creating an intensely personal oasis of tranquility in their own home.
