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Glory Road
Phillip Dexter and his family moved to the pristine city of Quanah, Texas in the summer of 1988 seeking the American Dream. Ronald Dexter left Edmonton, Alberta to work for the powerful oil giant Tricon Enterprise. Life was great until the horrifying accident one summer night in 1991 changed all their lives. With a greedy and reckless CEO, Tricon Enterprise works to shield the real truth behind the tragedy. Phillip's desire to seek revenge for his father's death pits him against the powerful oil giant, Tricon Enterprise, the legendary CEO Frank Beasley, and his son Mark Beasley. Phillip's quest for revenge is at a standstill, with the powerful oil giant the CEO having the upperhand. That is ...
DNA Microarrays and Related Genomics Techniques
Considered highly exotic tools as recently as the late 1990s, microarrays are now ubiquitous in biological research. Traditional statistical approaches to design and analysis were not developed to handle the high-dimensional, small sample problems posed by microarrays. In just a few short years the number of statistical papers providing approaches
Bayesian Missing Data Problems
Bayesian Missing Data Problems: EM, Data Augmentation and Noniterative Computation presents solutions to missing data problems through explicit or noniterative sampling calculation of Bayesian posteriors. The methods are based on the inverse Bayes formulae discovered by one of the author in 1995. Applying the Bayesian approach to important real-wor
The Invisible Rainbow
The most misunderstood force driving health and disease The story of the invention and use of electricity has often been told before, but never from an environmental point of view. The assumption of safety, and the conviction that electricity has nothing to do with life, are by now so entrenched in the human psyche that new research, and testimony by those who are being injured, are not enough to change the course that society has set. Two increasingly isolated worlds--that inhabited by the majority, who embrace new electrical technology without question, and that inhabited by a growing minority, who are fighting for survival in an electrically polluted environment--no longer even speak the same language. In The Invisible Rainbow, Arthur Firstenberg bridges the two worlds. In a story that is rigorously scientific yet easy to read, he provides a surprising answer to the question, "How can electricity be suddenly harmful today when it was safe for centuries?"
Design and Analysis of Single-Case Research
This book focuses on one important aspect of psychological research -- the intensive study of people measured one or more at a time. Some important historical material is detailed in several chapters making a strong connection to previous material in psychology. Several contributors present important details on classical and novel methods to study behavior over time, and they do so in the context of appropriate statistical methods. This appropriately reflects the growing interest in examining dynamic behaviors by objective measurement. Key experimental design principles are expertly stated, reflecting the growing interest in studying the individual course of development for invariants in beh...
Bayesian Modeling in Bioinformatics
Bayesian Modeling in Bioinformatics discusses the development and application of Bayesian statistical methods for the analysis of high-throughput bioinformatics data arising from problems in molecular and structural biology and disease-related medical research, such as cancer. It presents a broad overview of statistical inference, clustering, and c
Medical Biostatistics
Encyclopedic in breadth, yet practical and concise, Medical Biostatistics, Third Edition focuses on the statistical aspects of medicine with a medical perspective, showing the utility of biostatistics as a tool to manage many medical uncertainties. The author concludes "Just as results of medical tests, statistical results can be false negative or
Dose Finding by the Continual Reassessment Method
As clinicians begin to realize the important role of dose-finding in the drug development process, there is an increasing openness to "novel" methods proposed in the past two decades. In particular, the Continual Reassessment Method (CRM) and its variations have drawn much attention in the medical community, though it has yet to become a commonplace tool. To overcome the status quo in phase I clinical trials, statisticians must be able to design trials using the CRM in a timely and reproducible manner. A self-contained theoretical framework of the CRM for researchers and graduate students who set out to learn and do research in the CRM and dose-finding methods in general, Dose Finding by the...
Design and Analysis of Bridging Studies
As the development of medicines has become more globalized, the geographic variations in the efficacy and safety of pharmaceutical products need to be addressed. To accelerate the product development process and shorten approval time, researchers are beginning to design multiregional trials that incorporate subjects from many countries around the world under the same protocol. Design and Analysis of Bridging Studies addresses the issues arising from bridging studies and multiregional clinical trials. For bridging studies, the book explores ethnic sensitivity, the necessity of bridging studies, types of bridging studies, and the assessment of similarity between regions based on bridging evide...
Multiple Testing Problems in Pharmaceutical Statistics
Useful Statistical Approaches for Addressing Multiplicity IssuesIncludes practical examples from recent trials Bringing together leading statisticians, scientists, and clinicians from the pharmaceutical industry, academia, and regulatory agencies, Multiple Testing Problems in Pharmaceutical Statistics explores the rapidly growing area of multiple c
