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Free Radicals: from Basic Science to Medicine
Free radical-mediated reactions have been well known in chemistry and physical chemistry for many years. Applying this knowledge to living organisms, biochemists have shown that reactive free radicals are formed at many intracellular sites during normal metabolism, and they have started to suggest possible roles in various pathological processes and conditions, for example in radiation damage, in the metabolism of xenobiotics, in carcinogenesis and in metabolic disorders. At present, a large and relevant mass of experimental evidence supports the view that reactive free radicals are involved in the pathogenesis of several diseases and syndromes. This literature has captured the attention and...
Drug Transporters
A comprehensive guide to drug transporters that influence the absorption, distribution, and elimination of drugs in the body The development of powerful expression cloning and genome analysis techniques has facilitated the molecular identification and characterization of numerous transporters that play a crucial role in drug disposition. Explaining the principles of drug transport and the associated techniques, Drug Transporters: Molecular Characterization and Role in Drug Disposition: * Provides a comprehensive overview of drug transporters * Includes specific descriptions of transporter families, including substrate and inhibitor specificity, subcellular and tissue localization, mechanisms...
The Biliary System
The exponential expansion of knowledge in the field of hepatobiliary diseases makes systematic revisions of current concepts almost mandatory nowadays. This eBook summarizes the progress in understanding the molecular mechanism of cholesterol and bile acid metabolism and the physical-chemistry of biliary lipids, with emphasis on biliary lipid metabolism that is regulated by nuclear receptors in the hepatobiliary system. By guiding the readers through the various aspects of anatomy, physiology, and biochemistry of all "players" involved in bile formation, this eBook is intended to be a compendium of recent progresses in understanding the molecular mechanisms of cholesterol and bile acid metabolism. Table of Contents: Introduction / Anatomy of the Liver, Biliary Tract, and Gallbladder / Physical Chemistry of Bile / Hepatic Cholesterol Metabolism / Physical Chemistry and Hepatic Metabolism of Bile Acids / The Enterohepatic Circulation of Bile Acids / Hepatic Secretion of Biliary Lipids and Bile Formation / Summary / Acknowledgments / References / Author Biographies
The Wizard of Odds
In The Wizard of Odds, renowned and best-selling basketball writer Charley Rosen brings us for the first time the full life story of Jack Molinas, one of the greatest basketball players of his era, a man whose gambling addiction and hubris caused his ultimate demise. Drawing on numerous, previously unavailable first-person accounts, including Jack Molinas’s own journal and trial transcripts, Rosen presents the true saga of a man who perhaps better than anyone around him understood the weaknesses of the system in which he lived—so much so that he convinced himself that he could manipulate that system to his advantage with total impunity, in a life’s journey that took him from NBA play to the Mafia and the pornographic film industry, and to an ultimate tragic destiny.
International Review of Cytology
International Review of Cytology presents current advances and comprehensive reviews in cell biology – both plant and animal. Authored by some of the foremost scientists in the field, each volume provides up-to-date information and directions for future research. Articles in this volume address endogenous ligands of PACAP, VIP receptors in the autocrine-paracrine regulation of the adrenal gland; ultrastructural dynamcs of human reproduction, from ovulation to fertilization and early embryo development; chromosomal variation in mammalian neuronal cells; automated interpretation of protein subcellular location patterns; cell and molecular biology of human lacrimal gland and nasolacrimal duct mucins.
Silicon-Germanium Carbon Alloys
Carbon (C) and Silicon Germanium (SiGe) work like a magic sauce. At least in small concentrations, they make everything taste better. It is remarkable enough that SiGe, a new material, and the heterobipolar transistor, a new device, appear on the brink of impacting the exploding wireless market. The addition of C to SiGe, albeit in small concentrations, looks to have breakthrough potential. Here, at last, is proof that materials science can put a rocket booster on the silicon-mind, the silicon transistor. Scientific excitement arises, as always, from the new possibilities a multicomponent materials system offers. Bandgaps can be changed, strains can be tuned, and properties can be tailored. This is catnip to the materials scientist. The wide array of techniques applied here to the SiGeC system bear testimony to the ingenious approaches now available for mastering the complexities of new materials
Botticelli
"Sandro Botticelli ranks as one of the most outstanding artists of the Renaissance. Regarded as the inventor of the mythology painting and the creator of the first life-sized nude in modern painting, Botticelli also painted numerous portraits of the leading figures in Florentine society and witnessed the upsurge of religious fanaticism, channelling it productively into his work. Our notion of Renaissance art has been shaped by his key works Primavera and the Arrival (or Birth) of Venus. This volume, which provides the most detailed catalogue raisonne of Botticelli's paintings to date, examines every aspect of his creative output from the most recent methodical point of view."--Jacket.
Dave Bing
What kind of person loses sight in one eye and then through dedicated practice and honed skills becomes one of the top 50 NBA players of all time? What kind of person, with limited business experience, builds a start-up company into a thriving corporation and is recognized as one of the world’s most successful black executives? What kind of person, while running a $350 million business, takes the time to reach out to black youths lacking father figures and provides counsel and support? And what kind of person, instead of enjoying a well-deserved luxurious retirement, chooses to become mayor of a large city that many long ago had written off as dead? Dave Bing, that’s who. In Dave Bing, D...
Hydraulically Actuated Hexapod Robots
Legged robots are a promising locomotion system, capable of performing tasks that conventional vehicles cannot. Even more exciting is the fact that this is a rapidly developing field of study for researchers from a variety of disciplines. However, only a few books have been published on the subject of multi-legged robots. The main objective of this book is to describe some of the major control issues concerning walking robots that the authors have faced over the past 10 years. A second objective is to focus especially on very large hydraulically driven hexapod robot locomotion weighing more than 2,000 kg, making this the first specialized book on this topic. The 10 chapters of the book touch on diverse relevant topics such as design aspects, implementation issues, modeling for control, navigation and control, force and impedance control-based walking, fully autonomous walking, walking and working tasks of hexapod robots, and the future of walking robots. The construction machines of the future will very likely resemble hydraulically driven hexapod robots like the ones described in this book – no longer science fiction but now a reality.
