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Imperial Biologists
This book sheds light on a little-known aspect of the Imperial family of Japan: For three generations, members of the family have devoted themselves to biological research. Emperor Showa (Hirohito) was an expert on hydrozoans and slime molds. His son, Emperor Akihito, is an ichthyologist specializing in gobioid fishes, and his research is highly respected in the field. Prince Akishino, Emperor Akihito’s son, is known for his research on giant catfish and the domestication of fowl, while Prince Hitachi, Emperor Akihito’s brother, has conducted research on cancer in animals. The book shows how they became interested in biology, how seriously they were committed to their research, what thei...
Metabolic Adaptation to Cell Growth and Proliferation in Normal and Pathological Conditions
Proliferating cells must adapt their metabolism to fulfill the increased requirements for energy demands and biosynthetic intermediates. This adaptation is particularly relevant in cancer, where sustained rapid proliferation combined with the harsh conditions of the tumor microenvironment represent a major metabolic challenge. Noteworthy, metabolic reprogramming is now considered one of the hallmarks of cancer. However, the one size fits all rarely applies to the metabolic rewiring occurring in cancer cells, which ultimately depends on the combination of several factors such as the tumor’s origin, the specific genetic alterations and the surrounding microenvironment. In the present Research Topic, we compile a series of articles that discuss different metabolic adaptations that proliferating cells undergo to sustain growth and division, as well as the potential therapeutic window to treat certain pathologies, with a special focus on cancer.
Smart Infrastructure and Applications
This book provides a multidisciplinary view of smart infrastructure through a range of diverse introductory and advanced topics. The book features an array of subjects that include: smart cities and infrastructure, e-healthcare, emergency and disaster management, Internet of Vehicles, supply chain management, eGovernance, and high performance computing. The book is divided into five parts: Smart Transportation, Smart Healthcare, Miscellaneous Applications, Big Data and High Performance Computing, and Internet of Things (IoT). Contributions are from academics, researchers, and industry professionals around the world. Features a broad mix of topics related to smart infrastructure and smart applications, particularly high performance computing, big data, and artificial intelligence; Includes a strong emphasis on methodological aspects of infrastructure, technology and application development; Presents a substantial overview of research and development on key economic sectors including healthcare and transportation.
Marine Metagenomics
This book presents the state-of-art marine metagenome research and explains the method of marine metagenomic analysis in an easy-to-understand manner. Changes in the marine environment due to global warming and pollution have become a major global problem. Maintaining a healthy marine ecosystem requires advanced environmental monitoring and assessment systems. As such, the book presents a novel metagenomic monitoring method, which has been developed for comprehensive analyses of the DNA of microorganisms living in seawater to further our understanding of the dynamics of the marine environment. The book can be used as a primer for new researchers and as a manual on experimental methods.
Database Systems For Advanced Applications '97 - Proceedings Of The 5th International Conference On Database Systems For Advanced Applications
This volume contains the proceedings of the Fifth International Conference on Database Systems for Advanced Applications (DASFAA '97). DASFAA '97 focused on advanced database technologies and their applications. The 55 papers in this volume cover a wide range of areas in the field of database systems and applications - including the rapidly emerging areas of the Internet, multimedia, and document database systems - and should be of great interest to all database system researchers and developers, and practitioners.
Advances in Computational Biology
Proceedings of The 2009 International Conference on Bioinformatics and Computational Biology in Las Vegas, NV, July 13-16, 2009. Recent advances in Computational Biology are covered through a variety of topics. Both inward research (core areas of computational biology and computer science) and outward research (multi-disciplinary, Inter-disciplinary, and applications) will be covered during the conferences. These include: Gene regulation, Gene expression databases, Gene pattern discovery and identification, Genetic network modeling and inference, Gene expression analysis, RNA and DNA structure and sequencing, Biomedical engineering, Microarrays, Molecular sequence and structure databases, Molecular dynamics and simulation, Molecular sequence classification, alignment and assembly, Image processing In medicine and biological sciences, Sequence analysis and alignment, Informatics and Statistics in Biopharmaceutical Research, Software tools for computational biology and bioinformatics, Comparative genomics; and more.
The Phylogenetic Handbook
The Phylogenetic Handbook is a broad, hands on guide to theory and practice of nucleotide and protein phylogenetic analysis. This second edition includes six new chapters, covering topics such as Bayesian inference, tree topology testing and the impact of recombination on phylogenies, as well as a detailed section on molecular adaptation. The book has a stronger focus on hypothesis testing than the previous edition, with more extensive discussions on recombination analysis, detecting molecular adaptation and genealogy-based population genetics. Many chapters include elaborate practical sections, which have been updated to introduce the reader to the most recent versions of sequence analysis and phylogeny software, including BLAST, FastA, Clustal, T-coffee, Muscle, DAMBE, Tree-puzzle, Phylip, MEGA, PAUP*, IQPNNI, CONSEL, ModelTest, Prottest, PAML, HYPHY, MrBayes, BEAST, LAMARC, SplitsTree, and RDP. Many analysis tools are described by their original authors, resulting in clear explanations that constitute an ideal teaching guide for advanced-level undergraduate and graduate students.
The Phylogenetic Handbook
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Systems Biology
This book explores Systems Biology as the understanding of biological network behaviors, and in particular their dynamic aspects, which requires the utilization of mathematical modeling tightly linked to experiment. A variety of approaches are discussed here: the identification and validation of networks, the creation of appropriate datasets, the development of tools for data acquisition and software development, and the use of modeling and simulation software in close concert with experiment.
Introduction to Evolutionary Genomics
This book is the first of its kind to explain the fundamentals of evolutionary genomics. The comprehensive coverage includes concise descriptions of a variety of genome organizations, a thorough discussion of the methods used, and a detailed review of genome sequence processing procedures. The opening chapters also provide the necessary basics for readers unfamiliar with evolutionary studies. Features: introduces the basics of molecular biology, DNA replication, mutation, phylogeny, neutral evolution, and natural selection; presents a brief evolutionary history of life from the primordial seas to the emergence of humans; describes the genomes of prokaryotes, eukaryotes, vertebrates, and humans; reviews methods for genome sequencing, phenotype data collection, homology searches and analysis, and phylogenetic tree and network building; discusses databases of genome sequences and related information, evolutionary distances, and population genomics; provides supplementary material at an associated website.
