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Morphea and Related Disorders
Morphea and Related Disorders is a comprehensive reference on morphea. The book covers the subject in 20 chapters. The book starts with a detailed introduction and history of the morphea and its various classifications systems. Next, the book progresses into epidemiology, predisposing factors and pathogenic mechanisms, followed by histopathology for morphea diagnosis and a detailed review of clinical presentations. Subsequent chapters cover associated diseases and extracutaneous manifestations, medical investigations, treatment guidelines and special topics (Idiopathic atrophoderma of Pasini and Pierini, Linear atrophoderma of Moulin, Parry-Romberg syndrome, Lichen sclerosus, pediatric morph...
Caught Out - Shocking Revelations of Corruption in International Cricket
International cricket is being contaminated by crooked players, ruthless gamblers and bent officials. This staggering catalogue of revelations exposes appalling scandals involving the biggest names in the sport. Often under enormous pressure from gambling gangs who threaten serious physical harm and even abduction if their orders are not carried out, many of them have frequently and deliberately cheated. These riveting revelations will shock and disgust any fan and honest player, from those in school elevens and local clubs, right up to the sportsmen who play at county and international levels. Caught Out shines a light upon the most extraordinary cricketing tales, including the tragic death...
Nanocosmetics
Nanotechnology is key to the design and manufacture of the new generation of cosmetics. Nanotechnology can enhance the performance and properties of cosmetics, including colour, transparency, solubility, texture, and durability. Sunscreen products, such as UV nano-filters, nano-TiO2 and nano-ZnO particles, can offer an advantage over their traditional counterparts due to their broad UV-protection and non-cutaneous side effects. For perfumes, nano-droplets can be found in cosmetic products including Eau de Toilette and Eau de Parfum. Nanomaterials can also be used in cosmetics as transdermal drug delivery systems. By using smart nanocontainers, active compounds such as vitamins, antioxidants,...
Astrological Biographies
Astrological Biographies shows that the life of every individual is guided by the same set of stellar impulses and everyone, howoever eminent he may be has to bear his own cross. The sorrows and frustraions which invariably accompany every human being are inevitable parts of the process of growth and inner-unfoldment. The life of eminent personalities studies in this work in some degree or more represents the life of the millions who are struggling for more light and greater understanding of their own purpose existence.
Information, Communication and Computing Technology
This book constitutes the refereed proceedings of the 6th International Conference on Information, Communication and Computing Technology, ICICCT 2021, held in New Delhi, India, in May 2021. The 16 full papers and 4 short paper presented in this volume were carefully reviewed and selected from 83 qualified submissions. The papers are organized in topical sections on communication and network systems; computational intelligence techniques.
Public Policy and Politics in Georgia
After the break-up of the USSR, the former Soviet countries took different paths. While many of them face severe economic problems or have become only questionably democratic, Georgia’s socio-political development has become a relatively successful post-Soviet transition story. A deeper understanding of Georgia can offer insights that are also useful for other transitional and developing states. Many of the good governance implications of the research papers assembled in this volume are highly relevant to the broader Caucasus region and other post-Communist countries. The contributions deal with central issues pertinent to Georgian public policy, administration, and politics, as well as to Georgia’s ongoing struggle for independence and democracy. The collection illustrates a particularly revealing case in the comparative study of modern governance.
Novel Approach to Sustainable Temperate Horticulture
In the current scenario, marked by a continual improvement in living standards, it becomes imperative to boost the productivity as well as the efficiency of agriculture, especially horticulture, which holds the potential for significant economic prosperity aligning with Sustainable Development Goal number 8, "Decent Work and Economic Growth". Modern technological interventions, such as geospatial technology and geographic information system (GIS) technology, can be harnessed to yield effective results in addressing challenges and providing enhanced decision support, particularly in the planning of horticultural resource management. Cultivation and production of fresh produce face several cha...
Stress Response Pathways in Cancer
It is now established that dysregulated cell stress response pathways play a critical role in tumorigenesis, and a refined mechanistic understanding of this phenomenon at the molecular level promises to open new avenues for targeted therapeutic strategies that may benefit cancer patients in the near future. Coauthored by recognized leaders in cancer research from five continents, this novel book provides a comprehensive perspective on cell stress response pathways and therapeutic opportunities. Focusing on the role of genotoxic, proteotoxic, oxidative, metabolic, and inflammatory stress in tumorigenesis, the book is essential reading for students, basic researchers, and biomedical health care professionals interested in cancer and therapeutic development.
Comprehensive Textbook on Vitiligo
Vitiligo is a disorder having a significant impact in dark-skinned individuals. Along with the historical, cultural, and psychological aspects of the disease the multifactorial pathogenesis of this disorder is discussed in detail with special emphasis on the newer hypotheses proposed in the causation. Descriptions of the clinical aspects of the disease are supplemented with clinical photographs covering the latest therapeutic and surgical treatment options. Nonconventional treatments such as cosmetic camouflage and tattooing are also discussed. Topics of controversy such as the role of diet, patient selection for surgery, and so on, are covered in depth. Key Features Discusses the recent advances in treatment Evidence-based approach Quality of life and psychological aspects covered Nonconventional treatment options included with practical tips on vitiligo surgery Controversial topics covered
Unmasking metabolic dependencies for anti-cancer treatment in cancer
Over the last decade, our understanding of metabolism in the context of cancer has evolved greatly. It is now evident that altered cellular metabolism is an integral effector of tumorigenesis that is intricately intertwined with cell signaling as well as genetic and epigenetic regulation of diverse tumor programs. Recognizing the dysregulation of cellular metabolism as an important aspect of tumor function has offered new potential direction to seek clinical benefit by providing targets for the development of novel therapeutics. To-date, several small molecule inhibitors that target tumor or immune cell metabolism are being explored in active clinical trials as either preventive, stand-alone, or adjuvant therapies for various malignancies. Thus, identifying critical metabolic vulnerabilities in pre-neoplastic cells, cancer cells, and immune cells has direct and timely relevance for developing additional treatment and preventative strategies against cancer.
