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Itch - Management in Clinical Practice
Albeit a very common symptom in dermatology, internal medicine, psychosomatics, neurology, and even oncology, itching was under-researched up until 15 years ago. Since then, the clinical aspects of acute and chronic itch have been examined extensively. As a result, some books on the topic have become available. Whereas most publications focus on experimental aspects and diagnostics, this volume of the series 'Current Problems in Dermatology' provides a comprehensive overview regarding the management of chronic itch. Select authors consider interdisciplinary aspects as well as age, body region, and specific diseases as they present a great variety of available treatments. All physicians with patients suffering from itch – especially dermatologists, general practitioners, gerontologists, nephrologists, hepatologists, neurologists, and palliative care doctors – will find this publication to be an essential source of information.
Pruritus
This book provides a thorough and comprehensive reference in the management of pruritus, designed to be a convenient resource for all physicians confronted with patients suffering from itch. The Editors have recruited a board of internationally renowned experts to provide an in-depth analysis of the causes and management of pruritus, including the current concepts in pathophysiology and novel therapeutics. Acute and chronic pruritus can represent significant management issues both as a common physiological sensation and as a manifestation of dermatologic and non-dermatologic diseases. All patients suffering from itch know that it is a very awkward sensation. Unfortunately, this often significant symptom is frequently considered less severe in comparison with pain. The consequences are that research on this field has been poorer than research on pain and that pruritus is therefore more difficult to treat. Pruritus, Second edition addresses the new concepts and discoveries that have modified our understanding of this condition. It explains the pathophysiology of itch, describes all causes, and provides guidelines for management and treatment.
Statistical Techniques for Neuroscientists
Statistical Techniques for Neuroscientists introduces new and useful methods for data analysis involving simultaneous recording of neuron or large cluster (brain region) neuron activity. The statistical estimation and tests of hypotheses are based on the likelihood principle derived from stationary point processes and time series. Algorithms and software development are given in each chapter to reproduce the computer simulated results described therein. The book examines current statistical methods for solving emerging problems in neuroscience. These methods have been applied to data involving multichannel neural spike train, spike sorting, blind source separation, functional and effective n...
Pharmacology of Itch
Basic research on the pharmacology of itch has exploded in the wake of two very influential papers that were published in Nature (2007) and Science (2009). Long overlooked as a milder form of pain, itching has rapidly gained a new appreciation in both research and clinical communities because of its complexity and its negative effects on the quality of life of the distressed patients. Like pain, not all itches are the same. Unlike pain, there are no standard drugs equivalent to aspirin and morphine. Epidemiological studies emphasize the high incidence and economic costs of itch (pruritus). It is the most prevalent symptom of a wide variety of allergic and inflammatory skin conditions (e.g., ...
The Perplexing Physiology of the Nociceptive System
Impacts that threaten or indeed compromise the integrity of tissues trigger the development of a defence response, which through the activity of the nociceptive system includes pain. If the noxious impact does not induce tissue damage, the pain, called “nociceptive” pain, ceases within seconds after the impact is withdrawn. In contrast, if tissue damage does occur, a pain experience that usually persists until the injury is resolved and includes two major pathological sensory experiences, hypersensitivity to heat stimuli (i.e. heat hyperalgesia) and/or hypersensitivity to mechanical stimuli (i.e. mechanical allodynia) develop. The cellular and molecular mechanisms underlying the developm...
Practical Insights into Atopic Dermatitis
This book is a comprehensive, practical guide to the latest developments in the understanding and management of atopic dermatitis. Detailed information is provided on age-specific clinical symptoms, features, and diagnostic methods. Current theories on the pathogenesis of atopic dermatitis are closely examined, with attention to the roles played by genetic, allergic, immunologic, and skin barrier dysfunctions. In the second half of the book, the scientific background to and the practical use of the full range of treatment methods are described, covering topical agents, systemic agents, phototherapy, allergen-specific immunotherapy, and the most recently developed biologics and small molecules. This textbook will be an excellent guide to diagnosis and treatment for not only dermatologists but also practitioners in allergy and general medicine, including pediatricians, allergists, and primary care physicians. In addition, it will be of value for all scientists interested in developing new drugs for atopic dermatitis.
Pruritus Medicine
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Neurobiology of TRP Channels
During the last two decades, there has been an explosion of research pertaining to the molecular mechanisms that allow for organisms to detect different stimuli that is an essential feature for their survival. Among these mechanisms, living beings need to be able to respond to different temperatures as well as chemical and physical stimuli. Thermally activated ion channels were proposed to be present in sensory neurons in the 1980s, but it was not until 1997 that a heat- and capsaicin- activated ion channel, TRPV1, was cloned and its function described in detail. This groundbreaking discovery led to the identification and characterization of several more proteins of the family of Transient R...
