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For the second year in a row, we are very happy to offer our readership an ebook of 10 articles that have achieved widespread acceptance within our core audience and beyond. This time it concerns articles published in 2023, a landmark year for this journal, as it was officially awarded its first impact factor. These papers are among the large number that attained significant interest last year, but we selected just 10, which we consider to be the “best”. These articles have already made an impact in the form of original research or comprehensive reviews. As the Field Chief Editor, I would like to stand alongside our journal staff to honor all authors who contributed very high-level papers to the journal last year and are contributing to our success. We also thank the editors and reviewers of these papers, and of all papers this past year, for their invaluable contribution.
This book presents essential studies and cutting-edge research results on tau, which is attracting increasing interest as a target for the treatment of Alzheimer's disease. Tau is well known as a microtubule-associated protein that is predominantly localized in the axons of neurons. In various forms of brain disease, neuronal loss occurs, with deposition of hyperphosphorylated tau in the remaining neurons. Important questions remain regarding the way in which tau forms hyperphosphorylated and fibrillar deposits in neurons, and whether tau aggregation represents the toxic pathway leading to neuronal death. With the help of new technologies, researchers are now solving these long-standing questions. In this book, readers will find the latest expert knowledge on all aspects of tau biology, including the structure and role of the tau molecule, tau localization and function, the pathology, drivers, and markers of tauopathies, tau aggregation, and treatments targeting tau. Tau Biology will be an invaluable source of information and fresh ideas for those involved in the development of more effective therapies and for all who seek a better understanding of the biology of the aging brain.
This edition brings together analyses, statistics and directory data on the countries and territories of Western Europe.
Dear readers of Frontiers in Built Environment, As the Field Chief Editor for Frontiers in Built Environment, I am happy to present this curated selection of papers that have made a significant impact within our community. Among the large number of submissions that we received, these 14 papers represent some of the best published in 2023, the year when the journal attained its first impact factor. With many high-quality papers to consider, in selecting these 14 articles we faced the challenging task of how to include papers from across the 15 distinct sections of the journal whilst at the same time achieving a sense of cohesion to the ebook overall. However, amidst this diversity, we noticed...