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The first of its kind, this volume presents the latest research findings on the chaperonins, the best studied family of a class of proteins known as molecular chaperones. These findings are changing our view of some fundamental cellular processes involving proteins, especially how proteins fold into their functional conformations. - Origins of the new view of protein folding - Prokaryotic chaperonins - Eukaryotic chaperonins - Evolution of the chaperonins - Refolding of denatured proteins - Organelle biosynthesis - Biomedical aspects
Tumour markers are molecules occurring in blood or tissue that are associated with cancer, and whose measurement or identification is useful in patient diagnosis or clinical management. This book analyses potential signals of cancerous tumours, otherwise known as markers or indicators. This includes, direct and rapid determination of cancer antigen, potential tumour markers for cholangiocarcinoma, melanoma inhibitory activity, metastatic uveal melanoma, measurement of tumour oxygenation, bladder cancer markers, epithelial cell adhesion and progression markers in prostate tumours.
This book focuses on heat shock response-an active yet transient reprogramming of cellular activities to the needs of a stress protection mechanism designed to minimize heat damage and to optimize restoration of normal cellular activities after the stress period. This work places major emphasis on the structure and possible cellular functions of heat shock proteins as well as the analysis of heat shock protein-coding genes by transfection into homologous and heterologous expression systems. It also discusses heat shock effects on all levels of gene expression, on cell ultrastructure, and metabolic activities. This unique text is a must for all those who are involved with genetics, nucleic acids research, and cancer research.
Queueing Theory deals with systems where there is contention for resources, but the demands are only known probabilistically. This book can be considered to be a monograph or a textbook, and thus is aimed at two audiences: those who already know Queueing Theory but would like to know more of the Linear Algebraic Approach; and as a rst course for students who don't already have a strong background in probability, and feel more comfortable with algebraic arguments. Also, the equations are well suited to easy computation. In fact, there is much discussion on how various properties can be easily computed in any language that has automatic matrix operations (e.g., MATLAB). To help with physical i...
Peter J. Seymour was a Salish storyteller. He carried forward earlier tales of elders along with his own experiences as fewer and fewer native speakers were sharing the Colville-Okanagan language and oral literature. To thwart the demise of this language, over the course of a decade he passed along Salish stories not only to his family but also to linguist Anthony Mattina. The Complete Seymour: Colville Storyteller includes Seymour’s tales collected in the late 1960s and early 1970s, before his death. It documents Seymour’s rich storytelling and includes detailed morphological analyses and translations of this endangered language. This collection is an important addition to the canon of Native American narratives and literature and an essential volume for anyone studying Salish languages and linguistics.
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All students and professionals in statistics should refer to this volume as it is a handy reference source for statistical formulas and information on basic probability distributions. It contains carefully designed and well laid out tables for standard statistical distributions (including Binomial, Poisson, Normal, and Chi-squared). In addition, there are several tables of Critical Values for various statistics tests.