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Study of the Calcium Regulation Mechanism of TCR Activation Using Nanodisc and NMR Technologies
This thesis describes the use of biophysical and biochemical methods to prove that calcium has a positive feedback effect on amplifying and sustaining CD3 phosphorylation and should enhance T-cell sensitivity to foreign antigens. The study presented shows that calcium can regulate the signal pathway in cells not only as a secondary messenger but also through direct interactions with the phospholipid bilayer. The approach used in the thesis also represents an important advance, as it couples the use of nuclear magnetic resonance (NMR) to the analysis of signaling phenomena in living cells. Moreover, the thesis optimizes the Nanodisc assembly protocol, which can broaden its range of applications in membrane protein studies. A preliminary study on the structure of dengue virus NS2B-NS3p in complex with aprotinin, which may help to develop new drugs against the dengue virus, is also included.
Handbook on Immunosenescence
This authoritative handbook covers all aspects of immunosenescence, with contributions from experts in the research and clinical areas. It examines methods and models for studying immunosenescence; genetics; mechanisms including receptors and signal transduction; clinical relevance in disease states including infections, autoimmunity, cancer, metabolic syndrome, neurodegenerative diseases, frailty and osteoporosis; and much more.
Unwelcome Americans
Selected by Choice magazine as an Outstanding Academic Title In eighteenth-century America, no centralized system of welfare existed to assist people who found themselves without food, medical care, or shelter. Any poor relief available was provided through local taxes, and these funds were quickly exhausted. By the end of the century, state and national taxes levied to help pay for the Revolutionary War further strained municipal budgets. In order to control homelessness, vagrancy, and poverty, New England towns relied heavily on the "warning out" system inherited from English law. This was a process in which community leaders determined the legitimate hometown of unwanted persons or famili...
Signaling Mechanisms Regulating T Cell Diversity and Function
T cells play a vital role mediating adaptive immunity, a specific acquired resistance to an infectious agent produced by the introduction of an antigen. There are a variety of T cell types with different functions. They are called T cells, because they are derived from the thymus gland. This volume discusses how T cells are regulated through the operation of signaling mechanisms. Topics covered include positive and negative selection, early events in T cell receptor engagement, and various T cell subsets.
Flexible Ac Transmission Systems (FACTS)
Provides a comprehensive guide to FACTS, covering all the major aspects in research and development of FACTS technology.
Src-like Adaptor Protein: A Molecule that Regulates TCR/CD3 Expression by Adapting the E3 Ubiquitin Ligasec-Cbl to the TCR/CD3 Complex
Src-Like Adaptor Protein (SLAP) downregulates expression of the T cell receptor (TCR)/CD3 complex during a specific stage of thymocyte development when the TCR repertoire is selected. Consequently, SLAP -/- thymocytes display alterations in thymocyte development. Interestingly, mice deficient in either SLAP or c-Cb1 have very similar thymic phenotypes. We have studied the mechanism of TCR/CD3 downregulation by SLAP and c-Cb1. Using mice deficient for SLAP and/or c-Cb1 we demonstrate that thymocytes deficient in SLAP and/or c-Cb1 have increased TCRZeta chain expression due to a defect in TCRZeta degradation. Failure to degrade TCRZeta leads to an increased pool of fully assembled TCR/CD3 comp...
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