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Study of the Calcium Regulation Mechanism of TCR Activation Using Nanodisc and NMR Technologies
This thesis describes the use of biophysical and biochemical methods to prove that calcium has a positive feedback effect on amplifying and sustaining CD3 phosphorylation and should enhance T-cell sensitivity to foreign antigens. The study presented shows that calcium can regulate the signal pathway in cells not only as a secondary messenger but also through direct interactions with the phospholipid bilayer. The approach used in the thesis also represents an important advance, as it couples the use of nuclear magnetic resonance (NMR) to the analysis of signaling phenomena in living cells. Moreover, the thesis optimizes the Nanodisc assembly protocol, which can broaden its range of applications in membrane protein studies. A preliminary study on the structure of dengue virus NS2B-NS3p in complex with aprotinin, which may help to develop new drugs against the dengue virus, is also included.
Handbook on Immunosenescence
This authoritative handbook covers all aspects of immunosenescence, with contributions from experts in the research and clinical areas. It examines methods and models for studying immunosenescence; genetics; mechanisms including receptors and signal transduction; clinical relevance in disease states including infections, autoimmunity, cancer, metabolic syndrome, neurodegenerative diseases, frailty and osteoporosis; and much more.
Unwelcome Americans
Selected by Choice magazine as an Outstanding Academic Title In eighteenth-century America, no centralized system of welfare existed to assist people who found themselves without food, medical care, or shelter. Any poor relief available was provided through local taxes, and these funds were quickly exhausted. By the end of the century, state and national taxes levied to help pay for the Revolutionary War further strained municipal budgets. In order to control homelessness, vagrancy, and poverty, New England towns relied heavily on the "warning out" system inherited from English law. This was a process in which community leaders determined the legitimate hometown of unwanted persons or famili...
Signaling Mechanisms Regulating T Cell Diversity and Function
T cells play a vital role mediating adaptive immunity, a specific acquired resistance to an infectious agent produced by the introduction of an antigen. There are a variety of T cell types with different functions. They are called T cells, because they are derived from the thymus gland. This volume discusses how T cells are regulated through the operation of signaling mechanisms. Topics covered include positive and negative selection, early events in T cell receptor engagement, and various T cell subsets.
Flexible Ac Transmission Systems (FACTS)
Provides a comprehensive guide to FACTS, covering all the major aspects in research and development of FACTS technology.
Current Topics in Artificial Intelligence
This book constitutes the thoroughly refered post-proceedings of the 11th Conference of the Spanish Association for Artificial Intelligence, CAEPIA 2005, held in Santiago de Compostela, Spain in November 2005. The 48 revised full papers presented together with an invited paper were carefully selected. The papers span the entire spectrum of artificial intelligence from foundational and theoretical issues to advanced applications in various fields.
