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Thyroid Hormone MetabolismMolecular Biology and Alternate Pathways
This book gathers some of the most talented and well-informed experts in the field, who not only summarize the recent breakthroughs and new findings, but also shed light on future research. Special emphasis is placed on the exciting new understanding of the molecular structure of one of the major enzymes (type 1 iodothyronine deiodinase) involved in the activation of the thyroid hormone. This breakthrough culminates the major effort in this field around the world. As a result, we can study the regulation of thyroid hormone activation mechanism at the molecular level. Two other important deiodinase enzymes (types II and III) are also reviewed. Alternate pathways of thyroid hormone metabolism represent another major advance. These pathways are associated with a variety of physiological and disease states, including fasting, glucocorticoid excess, fetal development, and inflammatory and non-thyroidal illnesses. The understanding of these pathways assists us to better understand the physiological and biological basis of the disease process and thus to improve clinical management of patients with thyroidal and non-thyroidal illnesses.
Thyroid Gland Development and Function
As is the case in all fields of medicine, developmental endocrinology is now being studied at the molecular level. In this volume world-class researchers review the advances of the past decade in the study of normal and abnormal organogenesis of the thyroid gland and of the ontogeny of its function. They describe human thyroid development and its defects with the help of genetic studies in mouse models. Genetic defects of thyroid hormone synthesis are covered and their clinical relevance debated. The important field of thyroid cancer in the context of spontaneous occurrence and as part of familial neoplasia syndromes is described in detail. Finally, the important problem of environmental iodine deficiency which has emerged as a global public health concern is addressed. For the first time, a decade of work is presented in a concise and highly readable form. Offering valuable insight both for senior clinicians and graduate students, this publication will be of central interest to basic scientists involved in developmental biology as well as to pediatricians and endocrinologists dealing with patients with congenital disorders of thyroid function.
Oxford Textbook of Endocrinology and Diabetes
Now in its second edition, the Oxford Textbook of Endocrinology and Diabetes is a fully comprehensive, evidence-based, and highly-valued reference work combining basic science with clinical guidance, and providing first rate advice on diagnosis and treatment.
Thyroid Diseases
This book presents the latest advances in knowledge of the pathogenesis of thyroid diseases and describes the state of the art in their diagnosis and treatment, including newly emerging management approaches. After an opening section that addresses thyroid physiology and laboratory evaluation, each of the major thyroid diseases and their subtypes is discussed, covering goiter and thyroid nodule, thyroiditis, hypothyroidism, hyperthyroidism and thyrotoxicosis, and thyroid carcinoma. Other conditions that affect thyroid function or induce thyroid dysfunction are also considered, e.g., pregnancy, non-thyroidal disorders, and medication use. The book is designed to assist practitioners to achieve optimal outcomes in clinical routine by providing clear guidance on clinical examination, the use of diagnostic tests, first- and second-line therapies, and follow-up. Chapter have been written by recognized experts in the field.
Visser 't Hooft, 1900-1985
God's diplomat, the pope of the ecumenical movement, but also an acerbic theologian and a difficult person: this is how journalists characterised Willem Adolf Visser 't Hooft (1900-1985). He was one of the best-known Dutch theologians outside the Netherlands and he left his mark on the world church. Even at an early age he made profound efforts in support of international ecumenical youth and student organisations (Dutch Student Christian Movement, YMCA and World Student Christian Federation). He led the World Council of Churches during its formative stages (from 1938), and after its formal establishment in 1948 became its first general secretary, serving until 1966. To Visser 't Hooft, the unity of the church was both an article of faith and of a pragmatic organisation of church influence in a disunited world.
Oxford Desk Reference: Endocrinology
Oxford Desk Reference: Endocrinology provides easy access to evidence-based materials for quick consultation but also provides an in-depth expert reference for clinical practice. It covers the process of diagnosis, investigation, and management, as well as information for patients. Internationally-renowned experts have brought together evidence, guidelines and their clinical expertise to put trustworthy support at your fingertips. The vast spectrum of endocrine disorders are clearly laid out in self-contained topics for easy reference. Chapters build bridges between pathogenesis, clinical presentation, differential diagnosis and investigation to aid understanding. Careful consideration is gi...
Conflict, Improvisation, Governance
Conflict, Improvisation, Governance presents a carefully crafted and edited collection of first hand accounts of diverse public sector and non-profit urban practitioners facing the practical challenges of "doing democracy" in the global/local context of the interconnected major European city of Amsterdam and its region. The book examines street level democratic processes through the experiences of planning and city governance practitioners in community development, youth work, public service delivery, urban public administration, immigration and multi-cultural social policy. These profiles and case studies show widely shared challenges in global and local urban environments, and new, "bottom-up," democratic and improvisational strategies that community members and public officials alike can use to make more inclusive, democratic cities.
