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Pharmaceutical Substances
Pharmaceutical Substances is designed to be a complete reference guide to every pharmaceutical compound of significance. It is essential as a first point of reference not only for specialists in drug chemistry but also for anyone involved in the synthesis or use of pharmaceuticals. This reference work describes the production/isolation processes of about 1300 active pharmaceutical substances (including the syntheses of their intermediates) that are or have been marketed. In order to illustrate what particular information can be drawn from the book a typical monograph is depicted and labelled. Frequently-used abbreviations are explained in a separate list. With respect to the names of reagent...
Science of Synthesis: Click Chemistry
This reference work presents the state-of-the-art in the field of click chemistry, collecting the most useful, practical, and reliable methods. Click chemistry is a discipline that has grown rapidly since the introduction of this term by Barry Sharpless and Huisgen approximately two decades ago. Initially, click reactions mostly involved copper-catalyzed azide-alkyne cycloadditions and their applications to connect molecules, but gradually new types of click reactions were developed which also allowed a much wider range of applications throughout the chemical, biological, and materials sciences. This volume provides an overview of the most widely used click reactions and their scope and limitations. Written by pioneers and leaders in the field and including representative applications and experimental procedures. Newcomers to the field are enabled to instantly apply these reactions in synthesis.
Science of Synthesis: Advances in Organoboron Chemistry towards Organic Synthesis
The widespread use of organoboron compounds justifies the efforts devoted to their synthesis, as well as toward developing an understanding of their reactivity. The nature of the mono- or diboron species is of paramount importance in determining the reversible covalent binding properties of the boron atom with both nucleophiles and electrophiles. By wedding the rich chemical potential of organoboron compounds to the ubiquity of organic scaffolds, advanced borylation reactions have the potential to open unprecedented synthetic alternatives, and new knowledge in the field should encourage chemists to use organoboron compounds. In this volume, the main objective is to provide a collection of th...
Spectroscopic Methods in Organic Chemistry
Download Area for Lecturers:www.thieme.de/specials/hmz_en.html This book provides the necessary equipment for the application of spectroscopic methods in organic chemistry, as required as part of chemistry courses in all universities. The following methods are explained and examples given: UV/Vis Spectroscopy, derivative Spectroscopy, chirooptical methods CD and ORD. Aggregated molecules, charge transfer complexes, conjugated oligomers. Infrared (IR) and Raman Spectroscopy, Fourier transform IR spectroscopy, and GC/IRcombination methods. Nuclear Magnetic Resonance Spectroscopy (NMR), 1H-, 13C-, 19F-, 15N- und 31P-NMR, spin decoupling, triple resonance, INDOR difference spectroscopy, 2D- and ...
Science of Synthesis: Electrochemistry in Organic Synthesis
Applications of Electrochemistry in Synthesis Electrosynthesis represents an increasingly viable platform for molecular synthesis, which is currently undergoing a remarkable renaissance. The use of electricity can, for instance, avoid chemical redox reagents as well as the generation of byproducts derived thereof, setting the stage for improved resource economy. This volume is the defining reference work for this rapidly evolving research arena. It features a collection of the most practical and robust methods of organic electrosynthesis. It introduces the key concepts of electrochemistry and provides all relevant laboratory set-ups, enabling newcomers to the field the effective application of these powerful new tools to molecular syntheses. Innovative strategies that successfully realize topical challenging transformations by the art of electrosynthesis are presented. Pioneers and leaders in the field discuss both the practical and conceptual aspects of this rapidly evolving research field.
Protecting Groups
The didactic presentation of the material makes this book an essential bench-top tool not only for specialists in organic chemistry, but also for students and all those involved in the preparation of organic molecules. Key Features: A critical survey of the most used protecting groups, as used by organic chemists Organization based on functional groups: hydroxyl ; diol; carbonyl; carboxyl; amine Special emphasis placed on deprotection conditions applied to complex structures where selectivity is a prime issue Transformations accompanied by key experimental details Examples from the recent literature span a wide domain of organic synthesis Over 500 schemes aid visual retrieval End-of-chapter list reviews which amplify topics covered.
