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Environmental risk factors – noise, air pollution, chemical agents, and ultraviolet radiation – impact human health by contributing to the onset and progression of noncommunicable diseases. Accordingly, there is need for preclinical and clinical studies and comprehensive summary of major findings. This book is a state-of-the-art summary of these myriad severe life stressors. The chapters on the different pollutants focus on disease mechanisms (cardiovascular, neurological and metabolic disorders) and on oxidative stress and inflammation. The editors emphasize emerging mechanisms based on dysregulation of the circadian clock, the microbiome, epigenetic pathways, and cognitive function by environmental stressors, and introduce the exposome concept while highlighting existing research gaps. Key Features: Links various environmental stressors to the incidence of noncommunicable diseases Includes chapters on airborne toxins, chemical pollutants, noise, and ultraviolet radiation stressors Contributions from an international team of leading researchers Summarizes the impacts of stressors on disease mechanisms
This book provides a thorough and up-to-date overview of the aryl hydrocarbon receptor (AHR) and its unique dual role in toxicology and biology. The coverage includes epigenetic mechanisms, gene expression, reproductive and developmental toxicity, signal transduction, and transgenic animal models. Featuring an internationally recognized team of authors at the forefront of AHR research, this resource provides a comprehensive reference for readers interested in understanding the full spectrum of AHR, from basic concepts, toxicology analysis, and models to polymorphism and related diseases.
This book is a rich source of information on skin disorders due to toxicants in the environment. State of the art knowledge is summarized concerning the molecular basis of skin damage caused by well-appreciated environmental noxae. The book also provides a uniquely comprehensive overview of the detrimental dermatological effects of exposure to air pollution and global climate change. A special focus is contact allergy, which, beyond representing a major problem in dermatotoxicology, serves as a prime example for the development of toxicological approaches to risk assessment. A further chapter is devoted to contact urticaria, a condition that can progress to life-threatening anaphylactic reactions. The novel information offered in this book will enable the reader to go beyond the traditional thinking of dermatotoxicology and achieve a modern appreciation of the highly complex interplay between skin and environment.
Die Jahresberichte des Fachgebietes Lichttechnik lassen sich zurückverfolgen bis in das Jahr 1971. Sie informieren über die Lehrveranstaltungen des Fachgebiets, berichten über aktuelle Forschungsvorhaben und geben einen Überblick über Mitarbeiter, Publikationen und Veranstaltungen im Berichtsjahr. The annual report describes the activities of the chair in 2014. Apart from a brief introduction it gives an acount of the activities in teaching and about current research projects.
Toxic chemicals, either from fire ground combustion, contaminated PPE, or off-gassing from PPE material and chemical finishing have become the leading concern for the long-term health of firefighters. Exposure to fine smoke particles and toxic chemicals released from fire scenes can result in cancer, cardiovascular disease, and other pathological diseases, and minimizing this exposure has become a health priority for the firefighter. Firefighters face exposure to smoke at fire grounds and to contaminants in fire stations, vehicles, and even their homes because of resuspended fine particles or released volatile chemicals from contaminated PPE.