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Cancer Epidemiology and Prevention
This much anticipated Third Edition provides a comprehensive presentation of the global burden and patterns of cancer occurrence, along with new developments in our understanding of cancer causation and prevention. Special attention is given to epidemiologic approaches that incorporate molecular biomarkers based on genomic and other emerging technologies, providing new insights into the role of genetic predisposition and gene-environment interactions in cancer induction. In addition, new chapters are included on social class disparities in cancer incidence and mortality, the role of obesity and physical inactivity in cancer etiology, the potential effects of electromagnetic fields and rediofrequency radiation, and the principles of cancer chemoprevention. The textbook is organized into five sections: Basic Concepts; The Magnitude of Cancer; The Causes of Cancer; Cancer by Tissue of Origin; Cancer Prevention and Control. In this new edition, Drs. David Schottenfeld and Joseph F. Fraumeni, Jr. have enlisted three distinguished Associate Editors: Drs. Jonathan Samet of Johns Hopkins University, Graham Colditz of Harvard University and Alice Whittemore of Stanford University.
INTRODUCTION TO CANCER BIOLOGY AND GENETICS
Cancer, a global health crisis, is projected by WHO to cause 10 million deaths by 2020, with a mortality rate of one in six. This has spurred intensive research for innovative treatments. Cancer arises from genetic abnormalities triggering uncontrolled cell division, presenting distinct hallmarks. Both inherited and acquired mutations transform cell behavior, resulting in abnormal growth, reproduction, and death. Environmental toxins and spontaneous mutations contribute to genetic changes, while hereditary factors predispose some individuals. Despite rapid advancements in targeted treatments and immunotherapy, therapy resistance remains a formidable challenge due to the disease's heterogeneity. Understanding cancer biology is crucial for developing effective treatments. This book provides a comprehensive overview, covering basic cell biology, genetics, cancer development mechanisms, immune system involvement, diagnostic methods, treatment modalities, including emerging therapies, and challenges like drug resistance. Geared towards students and researchers in biology, medicine, and oncology, it offers vital insights into combating this complex disease.
Endocrine Pathology with Online Resource
A much-needed comprehensive resource, Endocrine Pathology covers clinical, radiologic, biochemical, molecular, cytogenetic, immunologic and histopathologic aspects of endocrine disorders, including the full spectrum of both neoplastic and non-neoplastic lesions. The first section of the book provides an overview of the clinical presentations of endocrine diseases, while the second section reviews the wide variety of investigative techniques used in their diagnosis. The third and largest section provides a comprehensive tissue- and organ-based approach to the diagnosis of endocrine disorders, including morphologic, genetic and proteomic features with clinicopathologic correlations. All chapters are richly illustrated with numerous color images, tables and algorithms, and the book is packaged with a password, giving the user online access to all text and images. Written and edited by the world's leading experts, this comprehensive and up-to-date book is the definitive resource on endocrine pathology for all pathologists, endocrinologists and researchers.
Molecular Pathology Protocols
The era of molecular pathology has arrived. From its promising beg- nings in research laboratories, the field has grown, and continues to grow, to become a vital part of the care of an ever-increasing number of patients. Because of its recent emergence from the research taboratory, many molecuIar pathology protocols we still to be found in the primary litcramre, and have not appeared in a text. MO~PCU~Q~ Padhoiogy Protocob contains la- ratory protocoIs that have been developed by many of the authors for use in clinical molecular pathology laboratories and describe in detail Row to perform these assays. This book is therefore intended for clinical laboratory use by medical technologists and p...
Genetic Steroid Disorders
Genetic Steroid Disorders, Second Edition targets adult and pediatric endocrinologists, clinical geneticists, genetic counselors, reproductive endocrinologists, neonatologists, urologists, and psychoendocrinologists. It is designed to assist these specialists in the diagnosis and treatment of steroid disorders. This revision includes a new chapter on "Gonadotropins, Obesity and Bone" and new research on non-invasive prenatal diagnosis with cell-free DNA. Chapters are thoroughly updated covering steroid disorders, the genetic bases for the disorder and case presentations, This definitive reference belongs in every medical library! - Presents a comprehensive, translational look at all aspects ...
Blue Knights
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Surgery of the Thyroid and Parathyroid Glands E-Book
Bringing together more than over 120 expert contributors from otolaryngology, general surgery, endocrinology, and pathology, Surgery of the Thyroid and Parathyroid Glands, 3rd Edition, presents an interdisciplinary approach to surgical management and treatment of benign and malignant disease. This renowned text/atlas is an ideal resource at all levels of surgical experience: for residents and junior surgeons, it clearly provides all relevant anatomy, surgical procedures, and workup; for experienced surgeons, it details the management of difficult cases, including revision surgery. Highly illustrated and accompanied by dozens of videos, this edition brings you up to date with the full continu...
Adrenocortical Carcinoma
We anticipate the book to be a definitive text on the subject that explores all aspects of the study of adrenal cancer and the treatment of patients with the disease. Chapters will cover epidemiology, pathogenesis, genetics, cancer stem cells, historic and emerging therapies, mouse models of adrenal cancer, new developments in tumor profiling, worldwide collaborative groups and tumor registries together with resources for the practitioner and community of adrenal cancer scientists. We do not wish this book to compete with the other larger books in the Endocrine and Endocrine Surgery literature. In addition, it is not expected to cover benign adrenal diseases that have been covered in detail in other venues. We envision this book to be a very specialized and exhaustive text on basic, translational and clinical aspects of adrenal cancer.
