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Introduction to Systems Biology
This book is an introduction to the language of systems biology, which is spoken among many disciplines, from biology to engineering. Authors Thomas Sauter and Marco Albrecht draw on a multidisciplinary background and evidence-based learning to facilitate the understanding of biochemical networks, metabolic modeling and system dynamics. Their pedagogic approach briefly highlights core ideas of concepts in a broader interdisciplinary framework to guide a more effective deep dive thereafter. The learning journey starts with the purity of mathematical concepts, reveals its power to connect biological entities in structure and time, and finally introduces physics concepts to tightly align abstra...
The Impact of Systems Medicine on Human Health and Disease
Complex disorders including obesity, diabetes, fatty liver disease, cardiovascular disease and cancer are results from a combination of genetic, environmental and lifestyle factors. The prevalence of such disorders has increased dramatically in the last two decades and there is an urgent need for the development of new prognostic tools for the treatment of such diseases. However, this requires a deep understanding of the underlying molecular mechanisms involved in the occurrence of the diseases. With the advances in high throughput technologies, biological components of cells can be measured with a very high resolution and these data can be used for investigating whole systems properties usi...
The Poll Taxes of 1377, 1379, and 1381: Part 1: Bedfordshire-Leicestershire
Provides an intriguing and detailed picture of late fourteenth century EnglandPresents complex material in a clear formatThe English poll taxes of 1377, 1379, and 1381 taxed householders, wives, dependants, and servants individually. The tax records therefore provide information about people who are rarely, if ever, mentioned in other documents - frequently including details of occupations and relationships. The widely varying documents associated with the taxes are being published in three volumes, to make this massive resource accessible to social and economic historians, demographers, and genealogists. This first volume, which covers all three taxes for Bedfordshire to Leicestershire, includes extensive editorial descriptions of the documents, explanations of the collection and recording processes, and a discussion of the relevance and value of this exciting material. Full indexes of original and contemporary place names and a glossary of occupations will appear in the third volume.Readership: Scholars and students of medieval history, economic and social historians, local historians, genealogists.
House Documents
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Robert Bosch GmbH Patent Landscape Analysis – January 1, 1994 to December 31, 2013
The following analysis illustrates the underlying trends and relationships of U.S. issued patents of the subject company. The analysis employs two frequently used patent classification methods: US Patent Classification (UPC) and International Patent Classification (IPC). Aside from assisting patent examiners in determining the field of search for newly submitted patent applications, the two classification methods play a pivotal role in the characterization and analysis of technologies contained in collections of patent data. The analysis also includes the company’s most prolific inventors, top cited patents as well as foreign filings by technology area.
