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Unmasking metabolic dependencies for anti-cancer treatment in cancer
Over the last decade, our understanding of metabolism in the context of cancer has evolved greatly. It is now evident that altered cellular metabolism is an integral effector of tumorigenesis that is intricately intertwined with cell signaling as well as genetic and epigenetic regulation of diverse tumor programs. Recognizing the dysregulation of cellular metabolism as an important aspect of tumor function has offered new potential direction to seek clinical benefit by providing targets for the development of novel therapeutics. To-date, several small molecule inhibitors that target tumor or immune cell metabolism are being explored in active clinical trials as either preventive, stand-alone, or adjuvant therapies for various malignancies. Thus, identifying critical metabolic vulnerabilities in pre-neoplastic cells, cancer cells, and immune cells has direct and timely relevance for developing additional treatment and preventative strategies against cancer.
Comprehensive Clinical Plasma Medicine
This book presents the state of the art in clinical plasma medicine and outlines translational research strategies. Written by an international group of authors, it is divided into four parts. Part I is a detailed introduction and includes basic and recent research information on plasma sciences, plasma devices and mechanisms of biological plasma effects. Parts II and III provide valuable clinical insights f.e. into the treatment of superficial contaminations, ulcerations, wounds, treatment of cells in cancer, special indications like in heart surgery, dentistry, palliative treatment in head and neck cancer or the use of plasma in hygiene. Part IV offers information on how and where to qualify in plasma medicine and which companies produce and supply medical devices and is thus of particular interest to medical practitioners. This comprehensive book offers a sciences based practical to the clinical use of plasma and includes an extended selection of scientific medical data and translational literature.
The American Bar
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Interdenominational Faith Missions in Africa
It was not the European and American churches which evangelised Africa, but the mission societies. The missions from the Great Awakening such as the London Missionary Society and Church Missionary Society, or the Holy Ghost Fathers and the White Fathers, which started the process of Sub-Saharan Africa becoming a Christian continent are well known and documented. Less known, and less documented are the interdenominational faith missions which began in 1873 with the aim of visiting the still unreached areas of Africa: North Africa, the Sudan Belt and the Congo Basin. Missions such as the Africa Inland Mission or Sudan Interior Mission gave birth to some of the big churches like ECWA in Nigeria and Africa Inland Church in Kenya. It is the aim of this book to describe faith missions and their theology and to present an overview of the early development of faith missions insofar as they touched Africa.
Mitteilungen
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Chambers Global
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