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Mechanisms of Neuroinflammation and Inflammatory Neurodegeneration in Acute Brain Injury
Mechanisms of brain-immune interactions became a cutting-edge topic in systemic neurosciences over the past years. Acute lesions of the brain parenchyma, particularly, induce a profound and highly complex neuroinflammatory reaction with similar mechanistic properties between differing disease paradigms like ischemic stroke, intracerebral hemorrhage (ICH) and traumatic brain injury (TBI). Resident microglial cells sense tissue damage and initiate inflammation, activation of the endothelial brain-immune interface promotes recruitment of systemic immune cells to the brain and systemic humoral immune mediators (e.g. complements and cytokines) enter the brain through the damaged blood-brain barri...
The Black Mamba
Saints City. An island community where everything appears idyllic. But in the cityOs underworld, Lord Magnus and the dreaded Gangster Federation spread crime and corruption. Daniel Stone is a teenager grieving for his father, battling the Payne Brothers' Street Gang and trying to impress Kelly Montgomery, heiress to the cityOs most powerful firm, the Montgomery Corporation. Stone learns how the Montgomery Corporation has developed a pharmaceutical weapon in secret that can alter criminal minds to stop them reoffending. This discovery shapes his destiny and transforms him into the Black Mamba, a professional mercenary who hunts down and brings to justice the worst of society."
Nanobody
Nanobodies have become outstanding tools for biomedical research, diagnostics and therapy. Recent advances in the identification and functionalization of target-specific nanobodies now make nanobody-based approaches broadly available to many researches in the field. This book provides a compilation of original research articles and comprehensive reviews covering important and up to date aspects of research on nanobodies and their applications for immunoassays, proteomics, protein crystallization and in vitro and in vivo imaging.
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The White Christmas Inn
In this heartwarming, feel-good novel, a snowstorm brings a cast of very different characters together at a sleepy New England inn, just in time for Christmas—and maybe even in time for a Christmas miracle. A New England inn seems like the picture-perfect place to spend the holidays. But when a snowstorm shuts the roads and keeps them all inside, the guests find themselves worrying that this Christmas may not be exactly what they dreamed of. Molly just needs to keep her head down and finish her latest book, but her writer’s block is crippling. The arrival of Marcus, a handsome widower with two young girls, is exactly the distraction she doesn’t need. Hannah was hoping for a picturesque...
The P2X7 Receptor
This detailed volume covers diverse aspects of P2X7 receptor analysis, ranging from its molecular structure to related pharmacological and immunological tools, via its analysis in heterologous expression systems as well as assays using primary cells and whole animal models. After three introductory chapters that focus on its structure, ligands, and physiological functions, the book details the generation of antibody and nanobody tools for P2X7 receptors, provides protocols for the analysis of expressed P2X7 receptors with a focus on their electrophysiological analysis, as well as protocols for the investigation of P2X7 down-stream signaling in immune cells by flow cytometry. Mouse models and...
Fasting for Life
Increase fasting for health and wholeness.
