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Challenges and Current Research Status of Vertigo/Vestibular Diseases
Vertigo or vestibular disorders have become a common handicap across the globe, which poses a great burden on health care resources. Vertigo is not a disease entity per se, but rather a leading symptom of many etiologically different diseases. These conditions include dysfunction of the vestibular system, both peripheral (inner ear, vestibular nerve) and central (brainstem, cerebellum), functional dizziness, and diseases of other causes, including blood pressure regulation disorders, such as orthostatic dizziness, and adverse drug reactions. Previous studies demonstrated that vestibular disorders might be a modifiable condition and a possible target for secondary prevention of cognitive impairment due to aging, dementia, social isolation, late-life depression, frailty, and increased risk of mortality.
The Role of Mitochondria, Oxidative Stress and Altered Calcium Homeostasis in Amyotrophic Lateral Sclerosis: From Current Developments in the Laboratory to Clinical Treatments
Amyotrophic lateral sclerosis (ALS) is a rapidly progressive, devastating and fatal disease characterized by selective loss of upper and lower motor neurons of the cerebral cortex, brainstem, spinal cord and muscle atrophy. In spite of many years of research, the pathogenesis of ALS is still not well understood. ALS is a multifaceted genetic disease, in which genetic susceptibility to motor neuron death interacts with environmental factors and there is still no cure for this deleterious disease. At present, there is only one FDA approved drug, Riluzole which according to past studies only modestly slows the progression of the disease, and improves survival by up to three months. The sufferin...
Neuropsychology Through the MRI Looking Glass
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Geriatrie
Bei der Entwicklung dieses Lehrbuchs haben alle Beteiligten gemeinsam das Ziel verfolgt, das neue Standardwerk der deutschsprachigen Geriatrie zu präsentieren. Es beleuchtet die ganze Palette der Erkrankungen im höheren Lebensalter und der geriatrischen Syndrome, darunter Ernährungs- und Stoffwechselstörungen, Mobilitätsstörungen, Infektionskrankheiten, Tumorerkrankungen, Herz-Kreislauf- und Gefäßerkrankungen, neurologische Erkrankungen, die verschiedenen Formen des kognitiven Abbaus sowie Sarkopenie und Frailty. Zu weiteren wesentlichen Themen gehören das funktionelle Assessment, die Polypharmazie sowie die Palliativmedizin des älteren Patienten. Das Buch vermittelt ein Verständn...
Predictive Imagable Biomarkers for Brain Disorders
Recent research on Neurodegenerative disorders such as Alzheimer's Disease, Parkinson's Disease, etc. and Neuropsychiatric disorders such as Schizophrenia, has shown strong evidence that altered brain tissue structure, physiology, and connectivity reflect the extent of severity of behavioral and physical abnormalities. With the advancement of high field strength MR technologies like MRS (Magnetic Resonance Spectroscopy), fMRI (functional Magnetic Resonance Imaging) and DTI (Diffusion Tensor Imaging), it has become possible to non-invasively measure these changes brain microenvironment in terms of levels of antioxidants; neurotransmitters; regional activity, susceptibility and connectivity du...
Neuroimaging of Affective Empathy and Emotional Communication
A recent explosion of research, both with neurotypical adults and individuals with brain lesions, has been devoted to delineating the auditory, cognitive, and motor processes underpinning affective empathy and emotional communication. This Research Topic highlights this line of investigation by bringing together a methodologically diverse range of neuroimaging studies that further advance our knowledge of the precise neural mechanisms by which these critical aspects of human interaction are accomplished, how they break down after brain damage, and how they recover, laying the groundwork for developing effective interventions for people with deficits in these functions.
