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In recent years, significant progress in colorectal surgery has been made which includes laparoscopic techniques, pre-operative management, emergency colorectal surgery, fast track multimodal recovery, management of complex wound problems and colorectal cancer follow-up. "Contemporary Issues in Colorectal Surgical Practice" aims to bridge the gap between the journal article and the traditional textbook in these areas.
This book presents a contemporary review of the field of pain therapeutics, including the historical medicines which still dominate standard of care treatments, as well as the new mechanisms and combinations/reformulations that have dominated the regulatory approvals over the last decade. In addition this book provides a deep review of the key biological mechanisms currently under investigation for their utility into the treatment of pain, such as ion channels, opiates and others. Additional discussion highlights the current challenges of pain research, covering a range of topics from difficulties in identifying new targets and pre-clinical models to the current regulatory and commercial challenges. This background sets the scene for recent scientific developments in pain research, such as the drive for genetic validation of targets and the derivation of human cell platforms from stem cells. Finally, the book covers the discovery and development stories of two pain products approved in the last decade. These case studies for Lyrica and the Butrans patch, will give insight into the discovery and development challenges and successes for both an oral and non-oral product.
Fullerenes: From Synthesis to Optoelectronic Properties covers a host of topics in organic synthesis, photo- / radiation-chemistry, electron donor-acceptor interaction, supramolecular chemistry, and photovoltaics. The book reviews the state-of-the-art discoveries in these areas of "Fullerene Research" and presents selected examples to prove the potential of fullerenes as multifunctional moieties in well-ordered multicomponent composites. Fullerenes: From Synthesis to Optoelectronic Properties appeals to upper-level undergraduates, graduates, researchers, and professionals in the fields of condensed matter physicists; materials scientists; electrochemists; biochemists; solid-state, physical, organic, inorganic, and theoretical chemists; chemical, electrical, and optical engineers.
This book, based on a selection of invited presentations from a topical workshop, focusses on time-variable oscillations and their interactions. The problem is challenging, because the origin of the time variability is usually unknown. In mathematical terms, the oscillations are non-autonomous, reflecting the physics of open systems where the function of each oscillator is affected by its environment. Time-frequency analysis being essential, recent advances in this area, including wavelet phase coherence analysis and nonlinear mode decomposition, are discussed. Some applications to biology and physiology are described. Although the most important manifestation of time-variable oscillations is arguably in biology, they also crop up in, e.g. astrophysics, or for electrons on superfluid helium. The book brings together the research of the best international experts in seemingly very different disciplinary areas.
A practical guide on the essential principles for the effective care of patients during anaesthesia, surgery, and the recovery period.
Authoritative, comprehensive and definitive, Pulmonary Circulation builds on the success of its previous two editions by providing practising respiratory physicians with a highly-ordered, unique reference work on the structure, function and pathophysiology of the pulmonary circulation. New for the third edition: Thoroughly revised with comprehensive coverage from diagnosis and clinical evaluation of pulmonary hypertension, to imaging techniques, disorders and treatment A new truly global team of expert editors, authors and key opinion leaders provide a wealth of detail on the latest developments and issues New chapters, such as: paediatrics, critical care, special environments including high altitude and underwater More quality chapters, authors, illustrations with thorough and thoughtful referencing make this book a contemporary essential reference text Pulmonary Circulation remains an essential resource for pulmonary hypertension specialists and should prove invaluable in all respiratory, cardiac and intensive care units.
This heavily revised second edition of this critical book details the structure, function and imaging of the normal right heart both at rest and under the stresses of high altitude and exercise. Extensively revised chapters cover the pathophysiology and pathobiology of right heart dysfunction, both in experimental models and human disease, including congenital heart disease and pulmonary hypertension. The Right Heart provides a concise up-to-date guide on the latest advances in our understanding of role of the right heart in the cardiopulmonary circuit and is an indispensable up-to-date resource for clinicians interested in this topic.
Pre operative assessment of the surgical patient is a key part of the perioperative process. However, it is one that cannot be separated from the other aspects of perioperative management, both clinical and administrative, that ensures the safe and effective treatment of surgical patients. There are a number of books on the market that examine perioperative management anaesthesia and surgical nursing that are only able to touch on the pre-operative assessment process. Pre Operative Assessment & Perioperative Management sets out to be different, by bridging the gap between these texts and the evolving and developing area of practice that pre operative assessment has become in modern healthcar...
Phenylacetates: Advances in Research and Application: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Phenylacetates. The editors have built Phenylacetates: Advances in Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Phenylacetates in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Phenylacetates: Advances in Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.