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Molecular Mechanisms of Notch Signaling
This book describes the Notch signaling pathway with a focus on molecular mechanisms. The Notch signaling pathway is a seemingly simple pathway that does not involve any second messenger. Upon ligand binding two consecutive proteolytic cleavages of the NOTCH receptor release the Notch intracellular domain from the membrane. The Notch intracellular domain migrates into the nucleus and activates gene expression. Recently, new technologies allowed us to better understand this pivotal signaling cascade and revealed new regulatory mechanisms. The different chapters cover many aspects of the Notch signaling focusing on the mechanisms governing the receptor/ligand interaction as well as on the downstream intracellular signaling events. Aspects of both canonical and non-canonical signaling are discussed and the function of Notch signaling in physiological and pathological contexts are elucidated. This book is not only intended for experts but it should also be a useful resource for young, sprouting scientists or interested scientists from other research areas, who may use this book as a stimulating starting point for further discoveries and developments.
The Making of Outlander: The Series
See how the story of Jamie Frasier and Claire Beauchamp Randall comes to life on the screen with this official, photo-filled companion to the third and fourth seasons of the hit Starz television series based on Diana Gabaldon’s bestselling Outlander novels. From its very first episode, the Outlander TV series transported its viewers back in time, taking us inside the world of Diana Gabaldon’s beloved series. From the Scottish Highlands, to the courts of Versailles, to the shores of America, Jamie and Claire’s epic adventure is captured in gorgeous detail. Now, travel even deeper into the world of Outlander with this must-have insider guide from New York Times bestselling author and tel...
Flaws
This book examines the policymaking process following highly emotional events. It focuses on the politics of shark “attacks” by looking at policy responses to tragic shark bites in Florida, Australia, and South Africa. The book reviews these cases by identifying the flaws in the human-shark relationship, including the way sharks are portrayed as the enemy, the way shark bites are seen as intentional, and how policy responses appear to be based on public safety. Flaws identifies politicians as the true sharks of this story for their manipulation of tragic circumstances to protect their own interests. It argues that shark bites are ungovernable accidents of nature, and that we are “in the way, not on the menu.”
Mineralogy and Geochemistry of Gems
Gems have been used in the manufacture of jewellery and as ornaments since antiquity. Considering gems, recent statistics have shown that about 15 billion Euros are annually at stake. Nowadays, gemmology, i.e., the study of gem materials, is one of the most expanding fields in the earth sciences, positioned between academia and industry. As an applied science, in gemmology, the instruments used should be non- or microdestructive, and their cost should be reasonable both in terms of equipment and time consumption. Gemmology can also be used contribute to the development of pure science and in some cases, destructive techniques may have to be used. Taking into account the fact that gems are al...
Germans to America
Title of the first 10 volumes of the series is Germans to America : lists of passengers arriving at U.S. ports 1850-1855.
Migration from the Russian Empire: January 1888-May 1889
Compilation of data on passengers of Russian nationality who immigrated to the United States from Russian territories between 1875 and 1891. Passenger lists are arranged chronolgically by date of arrival at New York harbor.
Focus on Dyslexia Research
Dyslexia is a brain-based type of learning disability that specifically impairs a person's ability to read. Although the disorder varies from person to person, common characteristics among people with dyslexia are difficulty with phonological processing (the manipulation of sounds) and/or rapid visual-verbal responding. The syndrome of dyslexia does not imply low intelligence or poor educational potential, and is independent of race and social background. Although dyslexia seems to be more prevalent among males than females, the exact ratio is unknown: the most commonly quoted figures are between 3:1 and 5:1. The evidence suggests that in at least two-thirds of cases, dyslexia has a genetic cause, but in some cases birth difficulties may play a role. Dyslexia may overlap with related conditions such as dyspraxia, attention deficit disorder (with or without hyperactivity) and dysphasia. In childhood, its effects can be misattributed to emotional or behavioural disorders. By adulthood, many dyslexics will have developed sophisticated compensating strategies that may mask their difficulties. This new book presents state-of-the-art research in this dynamic field.
