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The Evaluation of Surrogate Endpoints
Covers the latest research on a sensitive and controversial topic in a professional and well researched manner. Provides practical outlook as well as model guidelines and software tools that should be of interest to people who use the software tools described and those who do not. Related title by Co-author Geert Molenbergh has sold more than 3500 copies world wide. Provides dual viewpoints: from scientists in the industry as well as regulatory authorities.
The Evaluation of Surrogate Endpoints
Covers the latest research on a sensitive and controversial topic in a professional and well researched manner. Provides practical outlook as well as model guidelines and software tools that should be of interest to people who use the software tools described and those who do not. Related title by Co-author Geert Molenbergh has sold more than 3500 copies world wide. Provides dual viewpoints: from scientists in the industry as well as regulatory authorities.
Massive Graph Analytics
"Graphs. Such a simple idea. Map a problem onto a graph then solve it by searching over the graph or by exploring the structure of the graph. What could be easier? Turns out, however, that working with graphs is a vast and complex field. Keeping up is challenging. To help keep up, you just need an editor who knows most people working with graphs, and have that editor gather nearly 70 researchers to summarize their work with graphs. The result is the book Massive Graph Analytics." — Timothy G. Mattson, Senior Principal Engineer, Intel Corp Expertise in massive-scale graph analytics is key for solving real-world grand challenges from healthcare to sustainability to detecting insider threats, cyber defense, and more. This book provides a comprehensive introduction to massive graph analytics, featuring contributions from thought leaders across academia, industry, and government. Massive Graph Analytics will be beneficial to students, researchers, and practitioners in academia, national laboratories, and industry who wish to learn about the state-of-the-art algorithms, models, frameworks, and software in massive-scale graph analytics.
Exploration and Analysis of DNA Microarray and Other High-Dimensional Data
Praise for the First Edition “...extremely well written...a comprehensive and up-to-date overview of this important field.” – Journal of Environmental Quality Exploration and Analysis of DNA Microarray and Other High-Dimensional Data, Second Edition provides comprehensive coverage of recent advancements in microarray data analysis. A cutting-edge guide, the Second Edition demonstrates various methodologies for analyzing data in biomedical research and offers an overview of the modern techniques used in microarray technology to study patterns of gene activity. The new edition answers the need for an efficient outline of all phases of this revolutionary analytical technique, from preproc...
Research in Computational Molecular Biology
This book constitutes the proceedings of the 24th Annual Conference on Research in Computational Molecular Biology, RECOMB 2020, held in Padua, Italy, in May 2020. The 13 regular and 24 short papers presented were carefully reviewed and selected from 206 submissions. The papers report on original research in all areas of computational molecular biology and bioinformatics.
The Contribution of Young Researchers to Bayesian Statistics
The first Bayesian Young Statisticians Meeting, BAYSM 2013, has provided a unique opportunity for young researchers, M.S. students, Ph.D. students, and post-docs dealing with Bayesian statistics to connect with the Bayesian community at large, exchange ideas, and network with scholars working in their field. The Workshop, which took place June 5th and 6th 2013 at CNR-IMATI, Milan, has promoted further research in all the fields where Bayesian statistics may be employed under the guidance of renowned plenary lecturers and senior discussants. A selection of the contributions to the meeting and the summary of one of the plenary lectures compose this volume.
Practical Considerations for Adaptive Trial Design and Implementation
This edited volume is a definitive text on adaptive clinical trial designs from creation and customization to utilization. As this book covers the full spectrum of topics involved in the adaptive designs arena, it will serve as a valuable reference for researchers working in industry, government and academia. The target audience is anyone involved in the planning and execution of clinical trials, in particular, statisticians, clinicians, pharmacometricians, clinical operation specialists, drug supply managers, and infrastructure providers. In spite of the increased efficiency of adaptive trials in saving costs and time, ultimately getting drugs to patients sooner, their adoption in clinical ...
Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R
This book focuses on the analysis of dose-response microarray data in pharmaceutical settings, the goal being to cover this important topic for early drug development experiments and to provide user-friendly R packages that can be used to analyze this data. It is intended for biostatisticians and bioinformaticians in the pharmaceutical industry, biologists, and biostatistics/bioinformatics graduate students. Part I of the book is an introduction, in which we discuss the dose-response setting and the problem of estimating normal means under order restrictions. In particular, we discuss the pooled-adjacent-violator (PAV) algorithm and isotonic regression, as well as inference under order restr...
Data Science for Infectious Disease Data Analytics
Data Science for Infectious Disease Data Analytics: An Introduction with R provides an overview of modern data science tools and methods that have been developed specifically to analyze infectious disease data. With a quick start guide to epidemiological data visualization and analysis in R, this book spans the gulf between academia and practices providing many lively, instructive data analysis examples using the most up-to-date data, such as the newly discovered coronavirus disease (COVID-19). The primary emphasis of this book is the data science procedures in epidemiological studies, including data wrangling, visualization, interpretation, predictive modeling, and inference, which is of im...
