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This is the fifth edition of a very successful textbook on clinical trials methodology, written by recognized leaders who have long and extensive experience in all areas of clinical trials. The three authors of the first four editions have been joined by two others who add great expertise. A chapter on regulatory issues has been included and the chapter on data monitoring has been split into two and expanded. Many contemporary clinical trial examples have been added. There is much new material on adverse events, adherence, issues in analysis, electronic data, data sharing and international trials. This book is intended for the clinical researcher who is interested in designing a clinical tri...
“This book covers sixteen ‘famous trials’—some familiar to readers with a classical background, others less well known—all of which shed light on uncommon aspects of social and legal history. Liebs draws attention to two important but relatively understudied issues in particular: the role of the judge in procedure and the significance of trials and their outcomes in the evolution of Roman law.”—Jill D. Harries, Professor of Ancient History, University of St Andrews, and author of Cicero and the Jurists.
This comprehensive, unified text on the principles and practice of clinical trials presents a detailed account of how to conduct the trials. It describes the design, analysis, and interpretation of clinical trials in a non-technical manner and provides a general perspective on their historical development, current status, and future strategy. Features examples derived from the author's personal experience.
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A comprehensive volume on clinical trials that covers all important disease and therapeutic areas together with methodologies, phase I/II/III studies and other issues. The volume catalogues the impact of clinical trials on the practice of medicine and discusses the developments and practice of medical statistics. Cancer, cardiovascular disease, dermatological, dental, mental, ophthalmic health, gynaecology and respiratory diseases are all discussed in separate chapters, with discussions on outcome measures, competing risks and statistical models given for each therapy area. It also presents: * A history of clinical trials * A summary of pertinent statistical issues * How to choose a clinical trial design * Ethical constraints and considerations * Clinical trial issues in paediatrics and those involving older patients * Clinical trials in complementary medicine