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Optical Imaging of Brain Function and Metabolism
• . . . . At last the doctor will be freed from the tedious interpretation of screens and photographs. Instead, he will examine and scan through his patient directly. Wearing optical-shutter spectacles and aiming a pulsed laser torch, he will be able to peer at the beating heart, study the movement of a joint or the flexing of a muscle, press on suspect areas to see how the organs beneath respond, check that pills have been correctly swallowed or that an implant is savely in place, and so on. A patient wearing white cotton or nylon clothes that scatter but hardly absorb light, may not even have to undress . . . . •. David Jones, Nature (1990) 348:290 Optical imaging of the brain is a rap...
Optical Imaging of Brain Function and Metabolism 2
This volume covers the latest developments in optical imaging of the brain which is becoming an increasingly important functional neuroimaging method. Optical intrinsic signals offer unrivaled temporal and spatial resolution of functional measurements of the exposed brain cortex in animals and humans. Near-infrared spectroscopy and imaging ap proaches permit the noninvasive functional assessment of the human brain at bedside. Main advantages of these optical techniques are the biochemical specificity of the meas urements and the potential of measuring correlates of intracellular and intravascular oxy genation simultaneously. Recent data indicate that one may also measure a more direct correl...
Neuroinflammation in Stroke
The successful treatment of acute stroke remains one of the major challenges in clinical medicine. Over the last decades, the understanding of stroke pathophysiology has greatly improved, while the therapeutic options in stroke therapy remain very limited. Today, hyperacute mechanisms of damage, such as excitotoxicity, can be discriminated from delayed ones, such as inflammation and apoptosis. Targeting of inflammation has already been successfully applied in various stroke models, but translation into a clinically efficacious strategy has not been achieved so far. In this book, leading experts in basic cerebrovascular research as well as stroke treatment review the current evidence for and against an important role for inflammation in stroke, and explore the potential of treating or modulating inflammation in stroke therapy.
Optical Imaging of Brain Function and Metabolism 2
This volume covers the latest developments in optical imaging of the brain which is becoming an increasingly important functional neuroimaging method. Optical intrinsic signals offer unrivaled temporal and spatial resolution of functional measurements of the exposed brain cortex in animals and humans. Near-infrared spectroscopy and imaging ap proaches permit the noninvasive functional assessment of the human brain at bedside. Main advantages of these optical techniques are the biochemical specificity of the meas urements and the potential of measuring correlates of intracellular and intravascular oxy genation simultaneously. Recent data indicate that one may also measure a more direct correl...
THE EQIPD FRAMEWORK FOR RIGOUR IN THE DESIGN, CONDUCT AND ANALYSIS OF BIOMEDICAL EXPERIMENTS
Background and AimsWithin the last years, there has been growing awareness of the negative repercussions of unstandardized planning, conduct and reporting of preclinical research. Several initiatives have set the aim of increasing validity and reliability in reporting of studies and publications [Hirst et al., 2014, Percie du Sert et al., 2017, Hooijmans et al., 2014, Simera et al., 2010]. While these overlap significantly, they differ in detail, and show variance in generalizability or specific challenges for a single field. Additionally, reporting guidelines do not cover planning and conduct of studies, which face a similar situation [Henderson et al., 2013]. Consequently, it is hard for r...
Rodent Models of Stroke
In view of the numerous failures of clinical trials aimed at improving stroke therapy, the role and potential benefit of experimentally modeling focal cerebral ischemia in rodents has been debated. When methods of systematic review and metaanalyis are applied, however, it turns out that experimental models actually faithfully predicted the negative outcomes of clinical trials. In addition, thrombolysis and neuroprotection by hypothermia, first described in animal models, are key examples of treatment modalities that have made it successfully into clinical practice. In Rodent Models of Stroke, an international consortium of authors aims at critically addressing the issues on a very practical ...
Ich glaub, mich trifft der Schlag
Professor meets Science Slammer: So wurde das Gehirn noch nie erklärt Das Gehirn ist die Schaltzentrale unseres Körpers, das weiß jedes Kind. Doch wie schafft es diese Wunderbox, dass wir sehen, fühlen, sprechen, denken? Professor Ulrich Dirnagl von der Berliner Charité und Science Slammer Jochen Müller haben sich zusammengetan und erklären die Funktionsweise des Gehirns anhand von sechs neurologischen Krankheiten, unter anderem an Demenz, Schlaganfall und Epilepsie. Denn jede Störung, die im Gehirn auftritt, verrät uns, wie das gesunde Organ funktioniert. Der Schlaganfall zum Beispiel zeigt, welch großartiges Organisationstalent das Gehirn ist. Wenn bei einer Attacke das Sprachvermögen ausfällt oder der Bewegungsablauf gestört ist, können wir erkennen, wo diese Funktionen im Gehirn verortet sind. Hirnforschung für alle: Neurologe Ulrich Dirnagl und Science Slammer Jochen Müller erklären unterhaltsam, verständlich und anhand neuester wissenschaftlicher Erkenntnisse, wie das Gehirn funktioniert und was es jeden Tag für exzellente Arbeit leistet.
