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New Approaches to Drug Discovery
This volume gives an overview of state of the art technologies and future developments in the field of preclinical pharmaceutical research. A balanced mix of experts from academia and industry give insight in selected new developments in the drug discovery pathway. The topics cover the different parts of the drug discovery process, starting with new developments in the target identification and validation area. The lead generation part as a next step focuses on the requirements and technologies to identify new small molecules as lead compounds for further optimization; in a second section the technologies to identify biologics as leads are addressed. The final part focuses on the pharmacological models and technologies to characterize new compounds and the impact of biomarkers to facilitate the transfer of drug candidates into the development phase.
Mechanisms of Differentiation
Significant recent advances in cell culture technology now permit a detailed biochemical and molecular analysis of differentiation in both normal and tumor cells. These studies are important in attempting to understand the complex factors involved in normal growth and development, as well as the abnormalities associated with carcinogenesis. Mechanisms of Differentiation, Volumes I and II, is comprised of review chapters addressing various topics of current interest in this important area of research. Topics discussed include genes controlling differentiation, changes in gene expression during differentiation, induction of differentiation, induction of differentiation as a mode of action of chemotherapeutic agents, and the effect of cell shape, growth factors and differentiation modulating agents on the differentiated cell phenotype. Mechanisms of Differentiation is valuable to researchers involved in differentiation and development, carcinogenesis, cell biology, chemotherapy, and immunology.
Dirty Drugs
Psychische Erkrankungen gehoren epidemiologisch weltweit zu den verbreitetsten Krankheitsrisiken. Psychopharmaka pragen unsere Gesellschaft starker, als uns dies bewusst ist. Gleichwohl ist der rechtliche Rahmen der psychopharmakologischen Forschung und Therapie fragmentiert sowie teils von vorrationalen Pfadabhangigkeiten gepragt. Die vorliegende Untersuchung geht von der Geschichte der wissenschaftlichen Psychopharmakologie sowie den neurochemischen Wirkungsmechanismen typischer Psychopharmaka aus. Klaus Ferdinand Garditz analysiert die wildwuchsigen Regelungsstrukturen und die damit verbundenen Wechselwirkungen zwischen Pharmakologie, Gesellschaft und Recht als institutionelle Herrschafts...
