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Published Scientific Papers of the National Institutes of Health
Each issue lists papers published during the preceding year.
Scientific Directory and Annual Bibliography
Presents the broad outline of NIH organizational structure, theprofessional staff, and their scientific and technical publications covering work done at NIH.
Proteoglycan Protocols
Proteoglycans are some of the most elaborate macromolecules of mammalian and lower organisms. The covalent attachment of at least five types of glycosami- glycan side chains to more than forty individual protein cores makes these molecules quite complex and endows them with a multitude of biological functions. Proteoglycan Protocols offers a comprehensive and up-to-date collection of prepa- tive and analytical methods for the in-depth analysis of proteoglycans. Featuring st- by-step detailed protocols, this book will enable both novice and experienced researchers to isolate intact proteoglycans from tissues and cultured cells, to establish the composition of their carbohydrate moieties, to g...
Biology of Proteoglycans
Biology of Proteoglycans provides a representative, but by no means inclusive, sample of current research on the role of proteoglycans in the cell biology of the extracellular matrix. The book is organized into four areas: methodological developments; proteoglycan metabolism; proteoglycans in cartilage; and proteoglycans in "soft" tissues. It begins with discussions of current methodological developments which have had enormous impact on understanding the complexity of proteoglycan structure. These include the use of monoclonal antibodies to probe the structure of the protein and carbohydrate portions of proteoglycans; and studies on the genes that code for the proteoglycan protein cores and associated proteins. This is followed by separate chapters on various aspects of proteoglycan metabolism, including the synthetic pathway used by cells to synthesize proteoglycans containing heparin and heparan sulfate; the molecular organization of different proteoglycans in cartilage; the role of proteoglycans and associated proteins in the calcification process in growth plate; and the emerging field of proteoglycans in "soft" or noncartilagenous tissue.
Proteoglycans
This book provides a comprehensive, up-to-date review of the structure, biology, and molecular interactions of proteoglycans, consolidating into a single source research using molecular, cellular, and animal systems. Of particular note is an in-depth look at the role of heparan sulfate in modulating growth factors and morphogens.
Extracellular Matrix Influences on Gene Expression
Extracellular Matrix Influences on Gene Expression emerged from the Second international Santa Catalina Island Colloquium that deals with the discussion on the advances in the molecular biology of extracellular matrices and the epigenetic influences on cell function. Topics discussed include morphological descriptions, genetics, teratology, collagen heterogeneity, and mineralization. The book's 12 chapters discuss the chromosomal and extrachromosomal influences upon transcription, translational and post-translational regulations during development, and regulation of extracellular matrix molecular biosynthesis. The book describes the regulation of tissue-specific collagen biosynthesis and the...
Protides of the Biological Fluids
Proteins and Related Subjects, Volume 22: Protides of Biological Fluids covers the proteins of the intercellular matrix, along with the genetic defects and polymorphism of the human plasma proteins and isotachophoresis. The text first deals with the connective tissue proteins, along with the anabolic and catabolic enzymes of connective tissues. Next, the selection details the isolation and purification of various proteins, their metabolism, and function. The text also talks about the genetic defects and polymorphism of human plasma proteins, which includes the abnormalities of specific proteins. The last section covers the utilization of isotachophoresis as an analytical tool for the detection and characterization of amino acids, low-weight metabolites, and proteins. The book will be of great use to students, researchers, and practitioners of biological science.
Dental Research in the United States and Other Countries
A catalog of dental research projects sponsored by federal and non-federal organizations.
NIH Publication
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