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In Vitro Neuronal Networks
This book provides a comprehensive overview of the incredible advances achieved in the study of in vitro neuronal networks for use in basic and applied research. These cultures of dissociated neurons offer a perfect trade-off between complex experimental models and theoretical modeling approaches giving new opportunities for experimental design but also providing new challenges in data management and interpretation. Topics include culturing methodologies, neuroengineering techniques, stem cell derived neuronal networks, techniques for measuring network activity, and recent improvements in large-scale data analysis. The book ends with a series of case studies examining potential applications of these technologies.
Criticality as a signature of healthy neural systems: multi-scale experimental and computational studies
Since 2003, when spontaneous activity in cortical slices was first found to follow scale-free statistical distributions in size and duration, increasing experimental evidences and theoretical models have been reported in the literature supporting the emergence of evidence of scale invariance in the cortex. Although strongly debated, such results refer to many different in vitro and in vivo preparations (awake monkeys, anesthetized rats and cats, in vitro slices and dissociated cultures), suggesting that power law distributions and scale free correlations are a very general and robust feature of cortical activity that has been conserved across species as specific substrate for information sto...
The Functional Role of Critical Dynamics in Neural Systems
This book offers a timely overview of theories and methods developed by an authoritative group of researchers to understand the link between criticality and brain functioning. Cortical information processing in particular and brain function in general rely heavily on the collective dynamics of neurons and networks distributed over many brain areas. A key concept for characterizing and understanding brain dynamics is the idea that networks operate near a critical state, which offers several potential benefits for computation and information processing. However, there is still a large gap between research on criticality and understanding brain function. For example, cortical networks are not h...
Hybrid Systems Biology
This book constitutes the thoroughly refereed proceedings of the 6th International Workshop on Hybrid Systems Biology, HSB 2019, held in Prague, Czech Republic, in April 2019. The 8 full papers presented in this book together with 1 short paper and 3 invited papers were carefully reviewed and selected from 13 submissions. They cover topics such as: modeling and analysis of metabolic, signaling, and genetic regulatory networks in living cells; models of tissues, organs, physiological models; models and methods coping with incomplete, uncertain and heterogeneous information including learning for biological systems, parametric synthesis and inference; stochastic and hybrid models in biology; h...
Closing the Loop Around Neural Systems
Closed-loop neurophysiology has been accelerated by recent software and hardware developments and by the emergence of novel tools to control neuronal activity with spatial and temporal precision, in which stimuli are delivered in real time based on recordings or behavior. Real-time stimulation feedback enables a wide range of innovative studies of information processing and plasticity in neuronal networks. This Research Topic e-Book comprises 16 Original Research Articles, seven Methods Articles, and seven Reviews, Mini- Reviews, and Perspectives, all peer-reviewed and published in Frontiers in Neural Circuits. The contributions deal with closed loop neurophysiology experiments at a variety of levels of neural circuit complexity. Some include modeling and theoretical analyses. New enabling technologies and techniques are described. Novel work is presented from experiments in vitro, in vivo, and in humans, along with their clinical and technological implications for improving the human condition.
Biomimetic and Biohybrid Systems
This book constitutes the refereed proceedings of the second International Conference on Biomimetic and Biohybrid Systems, Living Machines 2013, held in London, UK, in July/August 2013. The 65 revised full papers presented were carefully reviewed and selected from various submissions. The papers are targeted at the intersection of research on novel live-like technologies inspired by scientific investigation of biological systems, biomimetics, and research that seeks to interface biological and artificial systems to create biohybrid systems
Goldoni: Volume One
Carlo Goldoni (1707 – 1793) was one of the most prolific and versatile playwrights of his century, even though most of his vast output deals with life confined to a few square miles of Northern Italy. This new edition contains two comedies about women surviving precariously in a man's world, but each taking a distinctly different approach to her problems. Mirandolina believes open dealing is essential; Valentina wants to have her cake and eat it, and uses intrigue to further her interests. Both are eager to win some kind of equality in a world in which they have no equality, only certain advantages, and almost come to grief. But these are worldly comedies and Goldoni does not deny us the satisfaction of seeing the women triumph.
Supply Chain Perspectives and Issues
The many manifestations of international production sharing have become the organizing theme for practically any discussion on production, trade, investment, development and international economic cooperation more generally. GVCs are at the economic heart of globalization. Policies of governments are central to outcomes, influencing the establishment, configuration and operation of GVCs in numerous ways. Technological possibilities and firm behaviour are also crucial determinants of what happens in the supply chain world. Global value chains (GVCs) have become ubiquitous. The literature that attempts to understand and explain GVCs is vast, multi-disciplinary and no less complex than the phenomenon itself. This volume is an ambitious attempt at a fairly comprehensive review of literature on the subject. --Publisher description.
