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Oral Drug Absorption, Second Edition thoroughly examines the special equipment and methods used to test whether drugs are released adequately when administered orally. The contributors discuss methods for accurately establishing and validating in vitro/in vivo correlations for both MR and IR formulations, as well as alternative approaches for MR an
More than 40 years ago, the observation that doxorubicin-resistant tumor cells were cross-resistant to several structurally different anticancer agents was the first step in the discovery of P-glycoprotein (P-gp). P-gp belongs to the superfamily of ATP-binding cassette (ABC) transporters;its overexpression has become a therapeutic target for overcoming multidrug resistance in tumors. However, P-gp is also expressed in cells of normal tissues where it plays a physiological role, by protecting them from the toxic effects of xenobiotics. Also, ABCB1 gene polymorphisms may influence the response to anticancer drugs substrate of P-gp. Several strategies to overcome P-gp tumor drug resistance have...
This book examines the underlying concepts, the history of environmental health, and the key factors that affect public health including air pollution, water contamination, industrial hazards and agricultural hazards.The increasing impact of global environmental issues is explored as they affect countries throughout the world.
50 years after the first Oxford Conference on Architectural Education, the 2008 conference brought together over 500 people from 42 countries to share best practice, discuss how, when, where and why we teach architecture now and in the future.
Papers presented at the International Workshop on Architectural & Urban Conservation held at Calcutta during December 16-18, 1994.
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