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Evaluating Evidence of Mechanisms in Medicine
This book is open access under a CC BY license. This book is the first to develop explicit methods for evaluating evidence of mechanisms in the field of medicine. It explains why it can be important to make this evidence explicit, and describes how to take such evidence into account in the evidence appraisal process. In addition, it develops procedures for seeking evidence of mechanisms, for evaluating evidence of mechanisms, and for combining this evaluation with evidence of association in order to yield an overall assessment of effectiveness. Evidence-based medicine seeks to achieve improved health outcomes by making evidence explicit and by developing explicit methods for evaluating it. T...
New Directions in the Philosophy of Science
This volume sheds light on still unexplored issues and raises new questions in the main areas addressed by the philosophy of science. Bringing together selected papers from three main events, the book presents the most advanced scientific results in the field and suggests innovative lines for further investigation. It explores how discussions on several notions of the philosophy of science can help different scientific disciplines in learning from each other. Finally, it focuses on the relationship between Cambridge and Vienna in twentieth century philosophy of science. The areas examined in the book are: formal methods, the philosophy of the natural and life sciences, the cultural and social sciences, the physical sciences and the history of the philosophy of science.
Techno-Scientific Practices
In scholarly debates, as well as in everyday parlance, we tend to pull science and technology apart: science gives us theory, and technology applies it. In practice, however, science and technologies are highly intertwined. In Techno-Scientific Practices: An Informational Approach, Federica Russo looks at the practice of science and elucidates the role of technologies and instruments in the process of knowledge production. In this exercise, it becomes evident that technologies cannot be analyzed on their own, but always in relation to epistemic agents. Thus, Techno-Scientific Practices emphasizes the importance of analyzing the process of knowledge production in techno-scientific contexts, in which there is a triad of relations to look at: us, the instruments, and the world. The book thus builds bridges between the philosophy of science, philosophy of technology, and science and technology studies in an unprecedent way.
Uncertainty in Pharmacology
This volume covers a wide range of topics concerning methodological, epistemological, and regulatory-ethical issues around pharmacology. The book focuses in particular on the diverse sources of uncertainty, the different kinds of uncertainty that there are, and the diverse ways in which these uncertainties are (or could be) addressed. Compared with the more basic sciences, such as chemistry or biology, pharmacology works across diverse observable levels of reality: although the first step in the causal chain leading to the therapeutic outcome takes place at the biochemical level, the end-effect is a clinically observable result—which is influenced not only by biological actions, but also p...
Explanation in Biology
Patterns of explanation in biology have long been recognized as different from those deployed in other scientific disciplines, especially that of physics. Celebrating the diversity of interpretative models found in biology, this volume details their varying types as well as explaining their relationships to one another. It covers the key differentials with other sciences in the nature of explanation, such as the existence in biology of varieties unheard of in the physical sciences, such as teleological, evolutionary and even functional explanations. Offering a wealth of fresh analysis of the phenomenon, chapters examine aspects ranging from the role of mathematics in explaining cell development to the complexities thrown up by evolutionary-developmental biology, where explanation is altered by multidisciplinarity itself. They cover major domains such as ecology and systems biology, as well as contemporary trends, such as the mechanistic explanations spawned by progress in molecular biology. With contributions from researchers of many different nationalities, the book provides a many-angled perspective on a revealing feature of the discipline of biology.
New Challenges to Philosophy of Science
This volume is a serious attempt to open up the subject of European philosophy of science to real thought, and provide the structural basis for the interdisciplinary development of its specialist fields, but also to provoke reflection on the idea of ‘European philosophy of science’. This efforts should foster a contemporaneous reflection on what might be meant by philosophy of science in Europe and European philosophy of science, and how in fact awareness of it could assist philosophers interpret and motivate their research through a stronger collective identity. The overarching aim is to set the background for a collaborative project organising, systematising, and ultimately forging an identity for, European philosophy of science by creating research structures and developing research networks across Europe to promote its development.
Mechanisms and Consciousness
This book develops a new approach to naturalizing phenomenology. The author proposes to integrate phenomenology with the mechanistic framework that offers new methodological perspectives for studying complex mental phenomena such as consciousness. While mechanistic explanatory models are widely applied in cognitive science, their approach to describing subjective phenomena is limited. The author argues that phenomenology can fill this gap. He proposes two novel ways of integrating phenomenology and mechanism. First, he presents a new reading of phenomenological analyses as functional analyses. Such functional phenomenology delivers a functional sketch of a target system and provides constraints on the space of possible mechanisms. Second, he develops the neurophenomenological approach in the direction of dynamic modeling of experience. He shows that neurophenomenology can deliver dynamical constraints on mechanistic models and thus inform the search for an underlying mechanism. Mechanisms and Consciousness will be of interest to scholars and advanced students working in phenomenology, philosophy of mind, and the cognitive sciences.
Film, Art, and the Third Culture
Murray Smith presents an original approach to understanding film. He brings the arts, humanities, and sciences together to illuminate artistic creation and aesthetic experience. His 'third culture' approach roots itself in an appreciation of scientific innovation and how this has shaped the moving media.
Evidence Contestation
This book examines the practices of contesting evidence in democratically constituted knowledge societies. It provides a multifaceted view of the processes and conditions of evidence criticism and how they determine the dynamics of de- and re-stabilization of evidence. Evidence is an essential resource for establishing claims of validity, resolving conflicts, and legitimizing decisions. In recent times, however, evidence is being contested with increasing frequency. Such contestations vary in form and severity – from questioning the interpretation of data or the methodological soundness of studies to accusations of evidence fabrication. The contributors to this volume explore which actors,...
Model Organisms
This Element presents a philosophical exploration of the concept of the 'model organism' in contemporary biology. Thinking about model organisms enables us to examine how living organisms have been brought into the laboratory and used to gain a better understanding of biology, and to explore the research practices, commitments, and norms underlying this understanding. We contend that model organisms are key components of a distinctive way of doing research. We focus on what makes model organisms an important type of model, and how the use of these models has shaped biological knowledge, including how model organisms represent, how they are used as tools for intervention, and how the representational commitments linked to their use as models affect the research practices associated with them. This title is available as Open Access on Cambridge Core.
