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Frontiers in the Pharmacological Manipulation of Intracellular cAMP Levels
Cyclic adenosine monophosphate (cAMP) is a second messenger of paramount biological importance, involved in the regulation of a significant number of cellular functions through the cAMP-dependent intracellular signal transduction pathways. The aim of this "Frontiers in Pharmacology" Research Topic was to attract contributions that highlight emerging ideas in the cAMP field that: (i) describe its role in cellular function and homeostasis, (ii) present the current approaches to its pharmacological manipulation, and (iii) clarify its central role in the development of more targeted therapeutic approaches toward a spectrum of diseases. The present collection of articles highlights, in a representative (but certainly not exhaustive) way, the research activity and emerging concepts in the field, while it also reveals the therapeutic potential that targeted pharmacological manipulation of intracellular cAMP levels could exert on a number of pathological conditions.
Cyclic Nucleotide Signaling and the Cardiovascular System
This book is a printed edition of the Special Issue "Cyclic Nucleotide Signaling and the Cardiovascular System" that was published in JCDD
Dynamics of cyclic nucleotide signaling in neurons
Cyclic nucleotides control a number of neuronal properties including neuronal differentiation, pathfinding, regulation of excitability and synaptic transmission, and control of gene expression. Signaling events mediated by cAMP or cGMP are transient and take place within the complex 3-dimensional structure of the neuronal cell. Signaling events happen on the time scale of seconds to minutes and the biological significance of the temporal dimension remains poorly understood. Structural features of neurons (dendritic spines and branches, cell body, nucleus, axon…) as well as AKAPs and other scaffolding proteins that keep signaling enzymes together and form "signaling microdomains", are criti...
Ovarian Aging and Reproduction
The ovary plays a very significant role in aging. The regenerative capacity of stem cells is the key factor to promote healthy aging, and the stem cell viability would decline sharply after the reproductive period, especially in women. Except for stem cell aging and neuroendocrine aging, ovarian aging is also a hotspot in the field of aging research. Recent researches have investigated many factors affecting ovarian function or aging, in terms of gene mutation, epigenetic erosion, endocrine dysfunction and environment-dependent extrinsic factors. This Research Topic aims to explore in detail all the factors related to ovarian aging and female reproduction outcomes. We'll discuss various age-...
cGMP: Generators, Effectors and Therapeutic Implications
After the discovery of endogenous NO formation in the late '80s and the 1998 Nobel Prize in Physiology or Medicine, many researchers and physicians again became interested in the NO/sGC interaction and cGMP-dependent signaling. This book is an enthusiastic celebration of cyclic guanosine monophosphate (cGMP) and amply illustrates the importance of this field of science to patients and the way in which the field has evolved. It is exclusively devoted to this exciting and important signaling molecule, addressing all recent advances in understanding guanylate cyclase regulation, NO/sGC interactions, cGMP effector mechanisms and their pathophysiological and pharmacological implications. Particular attention will also be given to clinical applications of the novel cGMP-elevating drugs which are on the horizon, thus spanning the continuum from basic science to clinic.
Building a new New World
An essential exploration of how Russian ideas about the United States shaped architecture and urban design from the czarist era to the fall of the U.S.S.R. Idealized representations of America, as both an aspiration and a menace, played an important role in shaping Russian architecture and urban design from the American Revolution until the fall of the Soviet Union. Jean-Louis Cohen traces the powerful concept of “Amerikanizm” and its impact on Russia’s built environment from early czarist interest in Revolutionary America, through the spectacular World’s Fairs of the 19th century, to department stores, skyscrapers, and factories built in Russia using American methods during the 20th century. Visions of America also captivated the Russian avant-garde, from El Lissitzky to Moisei Ginzburg, and Cohen explores the ongoing artistic dialogue maintained between the two countries at the mid-century and in the late Soviet era, following a period of strategic competition. This first major study of Amerikanizm in the architecture of Russia makes a timely contribution to our understanding of modern architecture and its broader geopolitics.
The Odd Man Karakozov
On April 4, 1866, just as Alexander II stepped out of Saint Petersburg's Summer Garden and onto the boulevard, a young man named Dmitry Karakozov pulled out a pistol and shot at the tsar. He missed, but his "unheard-of act" changed the course of Russian history-and gave birth to the revolutionary political violence known as terrorism. Based on clues pulled out of the pockets of Karakozov's peasant disguise, investigators concluded that there had been a conspiracy so extensive as to have sprawled across the entirety of the Russian empire and the European continent. Karakozov was said to have been a member of "The Organization," a socialist network at the center of which sat a secret cell of s...
