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Elizabeth Blackburn and the Story of Telomeres
The story of molecular biologist Elizabeth Blackburn and her groundbreaking research on telomeres and what it reveals about the resourceful opportunism that characterizes the best scientific thinking. Molecular biologist Elizabeth Blackburn—one of Time magazine's 100 “Most Influential People in the World” in 2007—made headlines in 2004 when she was dismissed from the President's Council on Bioethics after objecting to the council's call for a moratorium on stem cell research and protesting the suppression of relevant scientific evidence in its final report. But it is Blackburn's groundbreaking work on telomeric DNA, which launched the field of telomere research, that will have the mo...
Merchants of Immortality
A Discover Best Science Book of the Year: “A fascinating, accurate and accessible account of some of [the] contemporary efforts to combat aging” (The New York Times). Los Angeles Times Book Prize Finalist Named a Best Book of the Year by the New York Times, San Jose Mercury News, and Library Journal An award-winning writer explores science’s boldest frontier—extension of the human life span—interviewing dozens of people involved in the quest to allow us to live longer, better lives. Delving into topics from cancer to stem cells to cloning, Merchants of Immortality looks at humankind’s quest for longevity and tackles profound questions about our hopes for defeating health problems...
Telomeres and Telomerase
Telomeres and Telomerase Chairman: Sydney Brenner, 1997 Telomeres are the protective genetic elements located at the ends of chromosomes and are essential for correct chromosomal structure and function. They are not fully replicated by the conventional DNA polymerase system because DNA synthesis occurs only in the 5' to 3' direction and requires an RNA primer for initiation. Consequently, cells require a special enzyme to maintain the telomeric ends of chromosomes during each round of replication. This enzyme, telomerase, is a ribonucleoprotein that extends chromosome ends by adding short stretches of nucleotide repeats using a portion of its integral RNA component as the template. Recently,...
The Quest for Human Longevity
"Many scientists today are working to retard the aging process in humans so as to increase both life expectancy and the quality of life. Over the past decade impressive results have been achieved in targeting the mechanisms and pathways of aging. In The Quest for Human Longevity, Lewis D. Solomon considers these scientific studies by exploring the principal biomedical anti-aging techniques. The book also considers cutting edge research on mental enhancements and assesses the scientific doubts of skeptics. The Quest for Human Longevity is also about business. Solomon examines eight corporations pursuing various age-related interventions, profiling their scientific founders and top executives,...
Writing about Lives in Science
Following discussions on scientific biography carried out over the past few decades, this book proposes a kaleidoscopic survey of the uses of biography as a tool to understand science and its context. The authors belong to a variety of academic and professional fields, including the history of science, anthropology, literary studies, and science journalism. The period covered spans from 1732, when Laura Bassi was the first woman to get a tenured professorship of physics, to 2009, when Elizabeth H. Blackburn and Carol W. Greider were the first women's team to have won a Nobel Prize in science.
The Catalyst: RNA and the Quest to Unlock Life's Deepest Secrets
One of Literary Hub's Most Anticipated Books of 2024 Exploring the most transformative breakthroughs in biology since the discovery of the double helix, a Nobel Prize–winning scientist unveils the RNA age. For over half a century, DNA has dominated science and the popular imagination as the “secret of life.” But over the last several decades, a quiet revolution has taken place. In a series of breathtaking discoveries, the biochemist Thomas R. Cech and a diverse cast of brilliant scientists have revealed that RNA—long overlooked as the passive servant of DNA—sits at the center of biology’s greatest mysteries: How did life begin? What makes us human? Why do we get sick and grow old...
Modern Biopharmaceuticals, 4 Volume Set
The biopharmaceutical market has come along way since 1982 when the first biopharmaceutical product, recombinant human insulin, was launched. Over 120 such products are currently being marketed around the world including nine blockbuster drugs. The global market for biopharmaceuticals, which is currently valued at US$41 billion, has been growing at an impressive compound annual growth rate of 21% over the previous five years. With over one third of all pipe-line products in active development are biopharmaceuticals, this segment is set to continue outperforming the total pharmaceutical market and could easily reach US$100 billion by the end of this decade.
Nobel Lectures In Physiology Or Medicine (2006-2010)
Physiology or medicine was the third prize area Alfred Nobel mentioned in his will. Nobel had an active interest in medical research. He came into contact with Swedish physiologist Jöns Johansson through Karolinska Institute around 1890. Johansson worked for a brief period in Nobel's laboratory in Sevran, France during the same year. The Nobel Prize in Physiology or Medicine is awarded by the Nobel Assembly at Karolinska Institute. This volume is a collection of the Nobel lectures delivered by the Nobel Laureates, together with their biographies and the presentation speeches for the period 2006-2010.List of Laureates and their award citations:(2006) Andrew Z Fire and Craig C Mello — for t...
Les télomères
’évolution a doté les organismes eucaryotes de chromosomes linéaires, équipant chaque chromosome d’extrémités qui sont protégées par une structure particulière nommée « télomère ». L’effet considérable des télomères sur la stabilité globale du génome et leur implication dans le vieillissement et le cancer ont contribué à leur fascination. Cet ouvrage présente les télomères en tant qu’exemple de diversité et d’unité du vivant, à travers les nombreux modèles qui y sont décrits (ciliés, levures, cellules humaines ou modèle souris). Dans la première partie, les auteurs introduisent l’histoire de leur découverte, leurs rôles biologiques, leurs aspects structuraux (séquences, longueur, protéines du complexe shelterine, structures G4 et T-loop, compaction et ancrage) et fonctionnels (réplication, transcription, maintien). La seconde partie explore leurs dysfonctionnements, les conséquences sur la santé humaine et les approches thérapeutiques. Les télomères est rédigé par des chimistes, biochimistes, structuralistes et biologistes illustrant ainsi l’interdisciplinarité de l’étude des télomères.
