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Schaechter's Mechanisms of Microbial Disease
Schaechter's Mechanisms of Microbial Disease provides students with a thorough understanding of microbial agents and the pathophysiology of microbial diseases. The text is universally praised for "telling the story of a pathogen" in an engaging way, facilitating learning and recall by emphasizing unifying principles and paradigms, rather than forcing students to memorize isolated facts by rote. The table of contents is uniquely organized by microbial class and by organ system, making it equally at home in traditional and systems-based curricula. Case studies with problem-solving questions give students insight into clinical applications of microbiology, which is ideal for problem-based learning.
The Bacteria
The reviews in this volume deal with questions of the mechanisms of pathogenesis and with organisms that have only recently been extensively studied on the molecular level.**The introductory section presents an overview of pathogenesis, emphasizing common elements and genetic mechanisms of regulation and a review on the population genetics of bacterial pathogenesis. The second section deals with the regulation of synthesis of surface components and their role in the colonization of the host and/or of the host immune systems. The third section covers the invasion and intracellular growth of facultative and obligate intracellular parasites. The last section is devoted to studies of the role of bacterial toxic products in pathogenesis.
Regents' Proceedings
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D.R.D.A. Reporter
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The Activities of Bacterial Pathogens in Vivo
Pathogenic bacteria have unique biological properties, which enable them to invade a host and cause sickness. The molecular bases of these biological properties are the determinants of pathogenicity, and the research objectives are to recognize them, identify them chemically and relate their structure to function. Most of our present knowledge comes from studies with cultures in vitro. However, there is a rising interest in bacterial behaviour in the infected host and new methods have been developed for studying it. This book describes those methods and shows how they, and a recent surge in conventional studies, are shedding light on the activities of bacterial pathogens in vivo. It discusses bacterial and host factors that operate in vivo to cause illness, showing how phenomena recognized in vitro relate to behaviour in vivo and, if evidence of relevance is not available now, indicating how it might be obtained.
Principles of Bacterial Pathogenesis
Principles of Bacterial Pathogenesis presents a molecular perspective on a select group of bacterial pathogens by having the leaders of the field present their perspective in a clear and authoritative manner. Each chapter contains a comprehensive review devoted to a single pathogen. Several chapters include work from authors outside the pathogenesis field, providing general perspectives on the evolution, regulation, and secretion of virulence and determinants. - Explains the basic principles of bacterial pathogenesis - Covers diverse aspects integrating regulation, cellular microbiology and evolution of microbial disease of humans - Discusses current strategies for the identification of virulence determinants and the methods used by microbes to deliver virulence factors - Presents authoritative treatises of the major disease microorganisms
Signal Transduction and Bacterial Virulence
In order to survive, bacteria must constantly monitor their structure and physiology. Adaptive behaviours are established by using environmental sensors and response regulators. These communication modules regulate a wide variety of signals including host detection and invasion, cell cycle, metabolite utilization, starvation and many others. The purpose of this volume is to give an overview of the various systems and to introduce recent advances in understanding selected systems of pathogenic bacteria.
Mucosal Immunology
Mucosal Immunology, now in its fourth edition, is the only comprehensive reference covering the basic science and clinical manifestations of mucosal immunology. Most infectious agents enter the body through the various mucous membranes, and many common infections take place in or on mucous membranes, making this subject an area of singular importance in the field of immunology. This book contains new research data, exceptional illustrations, original theory, a new perspective, and excellent organization. It covers immune system topics, such as inductive and effector tissues and cells, and development and physiology of the mucosal barrier; diseases in the digestive system, respiratory tract, and genitourinary tract; and immunodeficiency. - The most comprehensive text on mucosal immunology from internationally recognized experts in the field - Includes exceptional color illustrations, new research data, original theory and information on all mucosal diseases - Contains nine new chapters and an expanded appendix
Thinking about Science
Thinking about Science: Good Science, Bad Science, and How to Make It Better A riveting exploration of the world of science, diving headfirst into its triumphs and tribulations. Penned by seasoned microbiologists Ferric C. Fang and Arturo Casadevall, this book offers a comprehensive analysis of the scientific enterprise through various lenses, including historical, philosophical, and personal. From their unique vantage points as researchers, clinicians, and educators, Fang and Casadevall dissect the intricate mechanisms of science, shedding light on its strengths and weaknesses. Through engaging historical anecdotes, personal narratives, and insightful academic studies, they present a candid...
